-多不饱和脂肪酸的研究与应用现状

211Vol.21No.120173JournalofEconomicAnimalMar．2017!。2016-11-11!![e-mail]!1222!!1．5500252．130118PUFAs。PUFAs、、、。Q547A1007-7448201701-0058-05．J．201721158-62．DOI10．13326/j．jea．2017．1164CurrentStatusontheＲesearchandDevelopmentofPolyunsaturatedFattyAcidsYINYunhou1CHENNingning2CHANGLei2WEIGongqing21．MediaCollegeofGuizhouMinzuUniversityGuiyang550025China2．CollegeofChineseMed-icineMaterialsJilinAgriculturalUniversityChangchun130118ChinaAbstractInrecentyearspolyunsaturatedfattyacidsPUFAshavebecomeoneoftheresearchhotspotsforscholars．BasedonthelargeamountofreferencesinthispapertheresearchprogressofPUFAs＇intypesandstructuressourcespreparationmethodsphysiologicalfunctionsandcurrentapplicationswerereviewedtoprovidereferencesforresearchanddevelopment．KeywordspolyunsaturatedfattyacidstypesandstructuresphysiologicalfunctionspreparationmethodscurrentapplicationsPUFAs192912050～60Hansen2Adam3。2070～80PUFAs、PUFAs。80Bang4PUFAs。90PUFAs。PUFAs、、。PUFAsPUFAs、、、。1PUFAsPUFAs2221118～22。PUFAsω－3ω－6n5。ω－3α－ALA、EPA、DPADHA6ω－6LA、γ－GLAAA7。ω－3ω－6PUFAs、。1PUFAsTable1．ThemaintypesandsourcesofPUFAsω－3ALA、、EPA、DHA、、DPAω－6LA、GLAAA2PUFAs2．1PUFAsPUFAs、、α－H8。9PUFAsPUFAs30dPUFAsSOD、GSH－Px。10PUFAsPUFAs175dSODP＜0．05PUFAs。2．2。PUFAs－11PUFAs12。Sarah13PUFAsⅠ。LA/ALA1∶1HepG2、14。2．3PUFAs、15。16-18PUFAs、、。PUFAsω－3PUFAs19。20ω－3PUFAsBcl－2/caspase。2．4PUFAs、、15。P．C．Calder21、、EPADHA。21PUFAs。2．5DHADHA10%DHA＞60%。DHA23。24PUFAs、。PUFAs。25ω－3PUFAsω－6PUFAs。2．6PUFAs952017。3PUFAs3．1、。PUFAs26。Yokochi27、、、。28PUFAsPUFAs。Vázquez29ω－3PUFAs。3．2。。。PUFAs30。、、31。Douglas32PUFAs。33PUFAs。3．3。Short-pathdistillation34。35。36EPADHAEPADHA。37。38PUFAs。3．4。PUFAs。PUFAs、39。Chakraborty40n－3PUFAs。41LipozymeＲMIM、。3．52070。、42。43。Michihata44DHAEPA。Létisse45CO2EPADHA。10.36%EPADHA23.96%。3．6PUFAs。π。46。0621147EPADHAEPADHA62．80%。48－α－α－96%。4PUFAs4．1PUFAs、、。。PUFAs、。PUFAs49。、、。4．2PUFAs“”。PUFAs。PUFAs。PUFAs。PUFAs50。4．3PUFAs、、、、。PUFAs、。。5PUFAs、。PUFAsPUFAs。PUFAsPUFAs。1GeorgeOBurrMildredMBurr．Anewdeficiencydiseasepro-ducedbytherigidexclusionoffatfromthedietJ．BioChem1929822345-367．2HansenAEWieseHFBoelscheANetal．ＲoleoflinoleicacidininfantnutritionJ．Pediatrics196331Sup1171-192．3AdamDJDHansenAEWieseHF．EssentialfattyacidsininfantnutritionJ．JNutr195866555-564．4BangHODyerbergJ．Plasmalipidandlipoproteinpatterningreenlandicwest-coasteskimosJ．NutritionＲeviews1986444143-146．5．J．2006261269-70．6．n-3J．2006652-54．7．n-6J．2006326960-963．8．J/OL．2016-10-28．http∥．cnki．net/kcms/detail/11．2206．TS．20161018．2221．040．html9．J．201127242875-2876．10．J．201127232707-2708．11．J．2014183139-145．12．J．·2009826-30．13CouchSCCrandellJKingIetal．Associationsbetweenlongchainpolyunsaturatedfattyacidsandcardiovascularlipidriskfactorsinyouthwithtype1diabetesNutritionAncillaryStudyJ/OL．JournalofDiabetesandItsComplications2016-10-02．http//dx．doi．org/10．1016/j．jdiacomp．2016．10．0216201714．n-6-3HepG2J．201711-8．15．J．2014837-41．16GriffittsJSaundersDTesiramYAetal．Non-mammalianfat-1genepreventsneoplasiawhenintroducedtoamousehep-atocarcinogenesismodelOmega-3fattyacidspreventliverne-oplasiaJ．BiochimicaEtBiophysicaActa20101801101133-1144．17．ω-3J．2013420-22．18．J．20132911810-811．19．J．2014311286-91．20．ω-3D．2012．21CalderPC．Longchainfattyacidsandgeneexpressioninin-flammationandimmunityJ．CurrentOpinioninClinicalNu-trition＆MetabolicCare2013164425-433．22．Omega-3D．2012．23．n-3D．2015．24．n-6n-3J．20062115-120．25．D．2014．26．J．2005444-46．27YokochiTUsitaMKamisakaY．Increaseintheγ-linolenicacidcontentbysolventwinterizationoffungaloilextractedfromMortierellagenusJ．JournaloftheAmericanOilChem-ists'Society19906711846-851．28．J．20151036-39．29VázquezLAkohCC．Enrichmentofstearidonicacidinmodi-fiedsoybeanoilbylowtemperaturecrystallisationJ．FoodChemistry20121301147-155．30．EPADHAJ．2013625-29．31．EPADHAJ．200828361-65．32DouglasGHayes．Effectoftemperatureprogrammingontheperformanceofureainclusioncompound-basedfreefattyacidfractionationJ．JournaloftheAmericanOilChemists'Society2006833253-259．33．D．2007．34．J．200328535-37．35．J．2002216617-621．36．M．200379-87．37．J．201136440-43．38．J．20125145-148155．39．EPADHAJ．2012340-43．40ChakrabortyKVijayagopalPChakrabortyＲD．PreparationofeicosapentaenoicacidconcentratesfromsardineoilbyBa-cilluscirculanslipaseJ．FoodChemistry20101202433-442．41．EPADHAJ．200530864-67．42．J．2014154772-4780．43．J．·2012839-42．44MichihataTMatsudYYasuoSetal．Extractionoflipidfromtheresideofika-ishiruusingsupercriticalcarborndioxideJ．JournalofJapaneseSocietyofFoodScience19974411795-800．45LétisseMＲozièresMHiolAetal．EnrichmentofEPAandDHAfromsardinebysupercriticalfluidextractionwithoutor-ganicmodifierI．OptimizationofextractionconditionsJ．JournalofSupercriticalFluids200638127-36．46．J．200021618-22．47．EPADHAJ．200833592-95．48．－α－J．200521147-54．49BenXMZhouXYZhaoWHetal．Growthanddevelopmentofterminfantsfedwithmilkwithlong-chainpolyunsaturatedfattyacidsupplementationJ．200411781268-1270．50．J．2008331242-46．26