氨基酸的侧链保护基团

氨基酸的侧链保护基团氨基酸侧链官能团保护基保护基结构式保护基脱除条件ArgNHNH2NHPbfOSHNOO95%TFA，30minAsp/GluOHOOtBuOO90%TFA，30minOAllOOPb(Ph3P)4-AcOH-NMM；Pb(Ph3P)4-PhSiH3inDCM，10-30minAsn/GlnNH2OTrtNH90%TFA，30-60minCysSHTrtS90%TFA，30-60minAcmSNHOHg(Ⅱ)；Ag(Ⅰ)；Tl(Ⅲ)；Ph（SO）Ph-CH3SiCl3tBuSHF（20℃）；Hg(Ⅱ)；Ph（SO）Ph-CH3SiCl3StBuSSRSH，Bu3POtherreducingagentsMmtSOMe0.5-1%TFAinDCM-TES（95：5），30min；3%TFA，5-10minTmobSMeOOMeOMe5%TFA-3%TESinDCMHisNHNTrtN50%TFAinDCM，30minLys/OrnNH2BocONHO90%TFA，30-60minAllocONHOPb(Ph3P)4（0.1eq）-PhSiH3（24eq）inDCM，10minMttNHMe1%TFAinDCM，30min；AcOH-TFE-DCM(1:2:7)DdeNHOO2%水合肼inDMF，5-10minSer/OHtBuO90%TFA，30minThr/TyrTrtO1-5%TFAinDCM，2-5minTrpHNBocNOO90%TFA，1h