电导检测器的原理及应用综述-潘超

2009GJA1003121111．3001932．300384。、、。O657．11A1672－7738201111－0663－03ReviewontheprincipleandprogressofconductivitydetectorPANChao1LIYan-mei2HUANGQiu-xia1GUODa-liang1LIUYu-xuan11．TianjinUniversityofTCMTianjin300193China2．TianjinScienhomeScientificCo．Ltd．Tianjin300384ChinaAbstractConductivitydetectorisaspecialdetectorforioncompoundordissociationalcompound．Structureworkingprinci-plesortscombinationwithotherdetectorsanddevelopmentofconductivitydetectorwerereviewedinthistissue．Conductivityde-tectormaybewidelyusedfordrugresearchinfuture．KeywordsConductivitydetectorResearchprogressWorkingprincipleCD、、。。、、。。。1pH。。、HXSO2NH3。。、。。21～4。2．1。。5S2－SO2－4SO2－4S2－。61mL·min－13mmol·L－1Na2CO33mmoL·L－1NaOHDIONEXDX－100T－3－。0．73μg·mL－1S/N=3107．84%94．81%。7NaOHHCN。3。HCNHCN。。、、、、、、、、、、。CD、、。、。·366··QiluPharmaceuticalAffairs2011Vol.30No.112．2CCD。。。Tuma8CE－CCD24242012、、、、、、、、1－、3－、β－、γ－。CE－CCD910、11、12、13、、A、、、0．1～6．25mg·L－1。HPLC。CE－CD。Gong14CE－CCD、、、、、、、、、、－β－、。3。3．1———10－8～10－9g·S－1。。。、。、、、、、。3．2//。UV－、UV－、UV－FD。UV。。FD。15FD/CCDFD/CCD。FD。/。。、、10－6～10－8mol·L－1。、、。pK。4、。HPLC、、、。1BreadmoreMCHaddadPRFritsJS．Optimisationoftheseparationofanionsbyionchromatography－capillarye-lectrophoresisusingindirectUVdetectionJ．JournalofChromatographyA20019201－231－40．2ChvojkaTJelínekIOpekarFetal．Dualphotometric－contactlessconductometricdetectorforcapillaryelectropho-resisJ．AnalyticaChimicaActa2001433113－21．3MroczekTGlowniakKWlaszczykA．Simultaneousdeter-minationofN－oxidesandfreebasesofpyrrolizidinealka-loidsbycation－exchangesolid－phaseextractionandion－pairhigh－performanceliquidchromatographyJ．Jour-nalofChromatographyA20019491－2249－262．4AlbertoJSlivaFDLargoCL．AnoscillometricdetectorforcapillaryelectrophoresisJ．AnalyticalChemistry199870204339－4343．5．J．20066177－79．6．－3－J．2001224supp376－377．7．J．2011324899－902．8TumaPSamcovaEAndelovaK．Determinationoffreea-minoacidsandrelatedcompoundsinamnioticfluidbycapillaryelectrophoresiswithcontactlessconductivityde-tectionJ．JournalofChromatographyB20068391－212－18．669·466··QiluPharmaceuticalAffairs2011Vol.30No.113．1、。。80．5%120mL·min－165℃。940%68%100g300g8min81．8%94．5%。Liew10、、。3．2。11、pH、、pH4．80．02%50℃10min。12BL934ZTC1+1AⅣ、BⅣ、ZTC1+1AⅣ1．5‰、BⅣ3‰、70℃。、。3．313B、Rg1、、、。HPD－100200mg·mL－13BV·H－160%。4。、、。1．J．201030221912－1914．2．J．201032101740－1742．3．J．200334127－30．4．J．201133157－60．5．J．2010326950－952．6．J．201030151317－1318．7．J．20031414－6．8．J．20001529－10．9．J．200259571－572．10LiewCV．TheinfluenceofoperationalvariableonmeansizeandgizedistributionofapheroldeproducedbyrotaryapheronizationJ．InterteationalJournalofPhamaceutics20022421－2345－348．11．J．200367413－414．12．J．201030221924－1925．13．J．201032122083－2087．6649．J．2006347991－994．10．J．2004231262－66．11．J．200423531－33．12．J．200426122256－2258．13．J．200525111329－1332．14GongXGKubanPTanyanyiwaJetal．Separationofen-antiomersincapillaryelectrophoresiswithcontactlesscon-ductivitydetectionJ．JournalofChromatographyA200510822230－234．15．－/J．2005335740－742．·966··QiluPharmaceuticalAffairs2011Vol.30No.11