甲钴胺在眼科的应用

(),()(,100053):R973:A:1006-2084(2011)20-3138-03:,,,,,,:;;ApplicationofMethylcobalamininOphthalmologyLIZhen,LIUDa-chuan.(DepartmentofOphthal-mology,XuanwuHospital,CapitalMedicalUniversity,Beijing100053,China)Abstract:Theeyeisanorganwithdenseinnervation.Thepathogenesisofmanyeyediseasescanaffecttheopticnerve,evencentralnervoussystem.Nervedamagedirectlyaffectstheprognosisofdiseases.Within-depthstudyoneyediseasesandincreasedrequirmentofgoodvisualfunctioninpatients,nerveprotectionismoreandmoreinvolvedinthetreatmentofeyediseases.Duetoitsgoodneuroprotectiveeffect,methylcobal-aminappliestothetreatmentofmanyeyediseases,andshowsgoodtherapeuticeffect.Hereistosummarizetheapplicationofmethylcobalaminintheeyediseases,andprovidebasisforophthalmologistsintheirclinicalapplication.Keywords:Methylcobalamin;Eyedisease;Opticnerve,,,,,,,1,,10%[1],[2],,,,,,[3],,3,100d2948,25,,,6,[4],3,66,1,,[5],,,,,,,2,:2.11.5,2000[6]25%[7],(diabeticretinopathy,DR)83132011101720MedicalRecapitulate,Oct.2011,Vol.17,No.20,DRDR,[8],DR,DR,[9]42(84),36,DR,3,6,DR2.2,(centralserouschorioretinopathy,CSC)CSC,,,,,,,CSC,,,,,(Schwann),,,,,CSC,CSC[10],,[11],1,CSC,CSC,55.9%,,[12]CSC,,,,,,,3,,,20%[13,14],,,,,[15](35),,83.33%,41.18%,[16]B12,,B12B1,2030dB12B1,312,,,,78.95%2,1,,,[17],,,1,2,,,,B12,4-(),,,,,93132011101720MedicalRecapitulate,Oct.2011,Vol.17,No.20,[18],,[19],,,,,[20](1.52.0mL,1,51)(2550mg/d,100200mg/d,12mg/d),,[21],,,5,,[22],B12B1,B12,B12[23]B12B12B12,B12,,B12[24],B12,,B12[(6.773.48)vs(8.714.54)],,,6,,,,,,,,[1]QuigleyHA.Numberofpeoplewithglaucomaworldwide[J].BrJOphthalmol,1996,80(5):389-393.[2]FosterPJ,BuhrmannR,QuigleyHA,etal.thedefinitionandclas-sificationofglaucomainprevalencesurveys[J].BrJOphthalmol,2002,86(2):238-242.[3],,,.[J].,2000,19(4):279-281.[4],,,.[J].,2001,21(6):430-432.[5]AraiT,KatsushimaH,UenoT,etal.Theeffectofmethylcobalonglaucomatousvisualfieldevaluation(part2)[J].FoliaOphthalmolJpn,1986,37:769-773.[6].[J].,2000,80(3):165-166.[7]MitchellP.Theprevalenceofdiabeticretinopathy:astudyof1300diabeticsfromNewCastleandtheHunterValley[J].AustJoph-thalmol,1980,8(3):241.[8],.[J].,2000,20(1):58-59.[9],.[J].,2006,15(20):2789-2790.[10].[M].2.:,1998:288.[11]KanekoT,YamanishiY,YamatsuK,etal.Pharmacologicalstudiesondegenerationandregenerationofperipheralnerves.(1)EffectsofmethylcobalaminandcobamideonEMGpatternsandlossofmuscleweightinratswithcrushedsciaticnerve[J].NipponYakurigakuZasshi,1976,72(2):259-268.[12].[J].,2007,42(11):979-981.[13].[M].:,1999:196-197.[14].[J].,1998,22(5):290-296.[15],,,.[J].,2005,13(2):173-174.[16],.[J].,2006,26(7):535-537.[17],.[J].,2004,6(3):157-160.[18],,,.[J].,1999,15(1):34[19],,,.[J].,2005,14(20):2679-2680.[20].[J].,2003,9(3):134-137.[21],,,.[J].,2005,9(17):24-25.[22],.35[J].,2009,6(25):68-69.[23].B12[J].,2010,10(2):222-223.[24],.B12[J].,2005,25(2):160-161.:2011-04-28:2011-07-1404132011101720MedicalRecapitulate,Oct.2011,Vol.17,No.20