肝损伤机制的研究-彭飞

1、SCIENCE&TECHNOLOGYINFORMATION2012NO.33SCIENCE&TECHNOLOGYINFORMATION2090,,,,11.1,,,,:,,,,,[1]12A,,,[2];[3]1.2(calbontetrachloride,CCI4,)Ca2+,ATP,,[4],,[5],,,Na+/Ca2+,Na+Ca+,,1.3,[6],ATP,[7]IP450,(MPT),,,;Ca2+;[8],,NaNa+/Ca2+,2P450,CYP450CYP450,[9]CYP450,,,2.1CYP450,CYP450,,,,,,CYP450,CYP450N--P-,,N--P-,[4]2.2,CYP450,,,CYP450,CYP450,,CYP450,[10]CYP450,,ATP,,,,CYP450P450-Fe3+-A-H,NADPH-CytP450-Fe3+,NADPH,FAD,P450-Fe2+-A-H,O,,e,2H+[11]CYP450,,33.1Ca2+Ca2+,Ca2+12*1(1.10;2.437100):,,,,,,:CYP450:R575:。

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