肝损伤机制的研究-彭飞

SCIENCE&TECHNOLOGYINFORMATION2012NO.33SCIENCE&TECHNOLOGYINFORMATION2090,,,,11.1,,,,:,,,,,[1]12A,,,[2];[3]1.2(calbontetrachloride,CCI4,)Ca2+,ATP,,[4],,[5],,,Na+/Ca2+,Na+Ca+,,1.3,[6],ATP,[7]IP450,(MPT),,,;Ca2+;[8],,NaNa+/Ca2+,2P450,CYP450CYP450,[9]CYP450,,,2.1CYP450,CYP450,,,,,,CYP450,CYP450N--P-,,N--P-,[4]2.2,CYP450,,,CYP450,CYP450,,CYP450,[10]CYP450,,ATP,,,,CYP450P450-Fe3+-A-H,NADPH-CytP450-Fe3+,NADPH,FAD,P450-Fe2+-A-H,O,,e,2H+[11]CYP450,,33.1Ca2+Ca2+,Ca2+12*1(1.10;2.437100):,,,,,,:CYP450:R575:A:1672-3791(2012)11(c)-0236-02:(187):,10:(1980,3,16),,,,,E-mail:[e-mail]&TECHNOLOGYINFORMATION2012NO.33SCIENCE&TECHNOLOGYINFORMATIONCa2+,,:(1)Ca2+,(XD)(XO),,,(2)Ca2+-ATP,ATP,,ATP,,[12](3)Ca2+Ca2+,,Na+-Ca2+-ATP;,DNA,[13],3.2CYP2E1H2O2,,,1-[14]:(1),DNA,,,[15];(2),,ATP,,[16];(3),I,[17]CYP2E1HepG2,GSH,,CYP2E1[18]3.3NONO,NO(iNOS)(L-Arg),LPS,NO,[19]NO,:(1)NO,(2)NO,(3)NO,DNA,(4)NO(NO-)n,,(5)NO,,cAMP,[20]4,,,,,,[1].[J].,2004(3):196-198.[2]RunnegarMT,BemdtN,KongSM,eta1Invivoandinvitrobindingofmicrocystintoproteinphosphatasesland2A[J].BiochemBiophysResCommun,1995,216:162-169[3]RunnegarMT,WeiX,HammmAlvarezSFIncreasedproteinphos-phorylationofcytoplasmicdyneinre-sultsinimpairedmotorfunction[J]BiochemJ,1999,342:l-6[4].[J].,2008,14(5):747-749.[5],.[J].,1990,6(1):7-10.[6],,,:[J].,2003,19(8):859-863.[7],.[M].7.,2008,1:81.[8]AeschkeH,GoresGJ,CederbaumAI,eta1MechanismofHepatotoxicity[J].ToxicolSci,2002,65:166-176[9],P450[J],2003,11(3):338-341.[10].[J].,2009,18:1659-1661.[11],.[M].2.,2010,12:97.[12],,,.[J].,2004,27(3):46-47.[13]DateM,MatsuzakiK,MatsnshitaM,etalDifferentialregulationofactivinAforhepatocytegrowthandfibronectinsynthesisinratliverinjury[J].Hepatol,2000,32(2):251-260.[14].[J].,2004,18(3):196-198.[15]JaeschkeH,GoresGJ,CederbaumAI,eta1Mechanismofhepatotoxicity[J].ToxicolSci,2002,65:166-176[16]ChenJ,RobinsonNC,SchenkerS,eta1Fornationof4-hydroxynonenaladductswithcytochromeCoxidaseinratsfollowingshort-termethanolintake[J].Hepatology,1999,29:17921798[17]FriedmanSL.Molecularregulationofhepaticfibrosis,anintegratedcellularresponsetotissueinjury[J].BiolChem,2000,275:2247-2250[18]HinsonJA,PikeSL,PumfordNR,eta1Nitrotyrosine-proteinadductsinhepaticcentrilobularareasfollowingtoxicdoesofacetaminopheninmice[J]ChemResToxicol,1998,11:604-607[19]LiSD,YuanBLEffeetofNOonacuteseverehepaticinjuryin-ducedbyin-tegrativeLPSandGaIN[J]ChinJModemMed,2005,15(16):1609-1616[20],.[J].,2009,15(7):1047-1050.