用ROC曲线确定最佳临界点和可疑值范围

[],,610041[](1976-),,,用ROC曲线确定最佳临界点和可疑值范围陈卫中,倪宗瓒,潘晓平,刘元元,夏彦[]:ROC,,,ROC:508176,ROC:ROC09723,,ROC,4070U/L,,(3690,4780)U/L,:ROC,[]ROC;;;[]R5414[]A[]10038507(2005)07072903RECEIVEROPERATINGCHARACTERISTICCURVESTODETERMINETHEOPTIMALOPERATINGPOINTANDDOUBTABLEVALUEINTERVAL.CHENWeizhong,NIZongzan,PANXiaoping,etal.WestChinaMedicalCenter,SichuanUniversity,Chengdu,610041.Abstract:Objective:ToevaluatetheclinicalvalueanddiscriminatorypowerofadiagnostickittodiagnoseCoronaryHeartDiseaseanddeterminetheOptimalOperatingPoint(OOP)usingtheReceiverOperatingCharacteristic(ROC)curves,andexplorethemethodtodeterminethedoubtablevalueinterval.Methods:BasedontheCAGandclinicalobservations,508peoplewiththediseaseand176withoutthediseasewereselectedtomeasuretheirOxLDL,andtheROCcurvewasplotted.Results:Theareaunderthecurvewas09723withahighstatisticalsignificance.ItshowedthatthediagnostickitwassuitableforCoronaryHeartDiseasescreening,theOOPofthediagnostickitwasdeterminedandinterpretedat4070U/Lwithhighersensitivityandspecificity.Thedoubtablevalueintervalof3690U/Lto4780U/Lwasdeterminedatthesametime.Conclusion:ItwasusefulusingROCcurvewhenassessingtheperformanceanddeterminingtheOOPanddoubtablevalueintervalofascreeningtest.KeyWords:OOP;ROC;Doubtablevalueinterval;CoronaryHeartDiseaseROC(receiveroperatingcharacteristic),,1,,[1]ROC[2]ROC,,,,ROC,,Youden[3],,,,,,,,,,,111,707,508,18~70;176,143,33;()2312ROC,Youden,2[4],23,221,1,1(U/L)5082018150215551319052023441311904350794020801766890184268051208015807073309263521401319052022ROC,,,(1-)ROC(2),7292005327ModernPreventiveMedicine,2005,Vol32,No709723,,Az=05,,23,,,Youden,,4070U/LROC(2A)9602%,9350%1ROC2ROC95%LCL95%UCLZP097230006209602098447655090000024,X,,,088,1-004,,,,098,1-0098,088098,(2BC)36904780U/L253(3690,4780)U/L,3,2=5854066,P00001,,(P)=06730Kappa=07576,333n36903690~47804780508463911424472214131765217412521762609233170191080154875070747166625577818125603ROC[5~9]ROC(Az)051Az05~07,;07~09,;09ROCAz=05,,,,09723,,Az=05,,,ROC,,Youden,4070U/LROC(9602%)(9350%),ROC,,,Youden,,,,,,,,,1(),[6],,,;,,,,,,,100%ROCROC,,,,[3],,,,,,,X,,100%,,,2[4],23,,36904780U/L,,Kappa07576,075,,,,ROC,ROC,,7302005327ModernPreventiveMedicine,2005,Vol32,No7,[][1]GregoryMark.Receiveroperatingcharacteristic(ROC)plots:FundamentalEvaluationToolinClinicalMedicine[J].ClinChem,1993,30(4):561-567.[2],,(ROC)[J].,2001,15(3):201-202.[3],,ROC[J].,1999,24(9):993.[4]SPSSROC[J].,2003,19(9):1152.[5],ROC[J].,1999,17(2):66.[6][M].:,2003.[7]HanleyJA,McNeilBJ.Themeaninganduseoftheareaunderareceiveroperatingcharacteristic(ROC)curve[J].Radiology,1982,143(4):29.[8]SwetsJA.Measuringtheaccuracyofdianosticsystem[J].Science,1988,240(4622):1285.[9]HanleyJA,McNeilBJ.Themeaninganduseoftheareaunderareceiveroperatingcharacteristic(ROC)curve[J].Radiology,1982:29-36.[]20041019[],,455000[](1966~),,,公共场所从业人员SARS相关知识调查韩文霞,赵亮[];;SARS;[]R5631[]B[]10038507(2005)07073101111,384,158,411%,226,589%;173,451%;136,354%;43,112%;32,83%12,SARS,,35,,,,,389,384,987%221SARSSARS,,100%,981%SARS2~14d737%,SARS1~2100%,SARS936%,SARS786%SARS100%,SARS100%172%SARS,404%,SARS,456%22SARS206%SARS,;169%SARS100%,346%;896%,,969%SARS(%);SARS,100%SARS805%SARS12100%,SARS100%,,SARS966%23SARS100%SARS,SARS,100%SARS846%SARS706%SARS,6h,12h24SARSSARS:547%471%284%320%268%294%25SARS100%,SARS977%,SARS869%,,781%,873%,100%;,100%,SARS962%,,SARS786%;SARS,922%;781%,346%,386%,861%,139%(771)7312005327ModernPreventiveMedicine,2005,Vol32,No7