衰减校正在18F-FDGSPECT符合成像中的临床价值

1572002,22(1):40-4218F-FDGSPECT100034AC18F-FDGSPECT36418F-FDGSPECTACNACT/B2818F-FDGSPECT9504ACNAC363494%ACNAC5526%ACNAC4100%ACNACT/BACP0.01T/BACP0.05T/BACNACP0.01AC28100%NACACP0.011760.7%621.4%ACP0.01ACNAC10.82±2.143.64±2.23P0.01AC18F-FDGTheclinicalvalueofattenuationcorrectionin18F-FDGSPECTcoincidenceimagingFUzhanli,LINjinghui,WANGrongfu,etal.Departmentofnuclearmedicine,thefirsthospitalofPekinguniversity,Beijing100034,ChinaAbstractObjectiveToassessthevalueofattenuationcorrection(AC)incoincidenceimagingwith18F-FDGSPECT.MethodsThirty-sixpatientswithmalignanttumorsand4patientswithbenignlesionsverifiedbyhistopathologywerestudiedusing18F-FDGSPECTcoincidenceimagingwith18F-FDG.TheimageswithACandwithoutAC(NAC)werereconstructediteratively,andtheratiosoftumor-to-background(T/B)werecalculatedinbothACandNACimages.ThemyocardialimagesobviousinSPECTcoincidenceimagingwith18F-FDGof28personswithoutthehistoryofheartdiseaseanddiabeteswerestudiedwithACandNAC.Theleftventricularmyocardiumwasdividedinto9segments,anda5-score-system(0:normal,4:defect)wasusedtoevaluatetheradioactivitydistributionineachsegmentofthebothimages.ResultsThirty-four(94%)ofthe36patientswithmalignanttumorsweredetectedinbothACandNACimagesandtotalof55lesionswerefound,while2(6%)patientswerefalsenegativeinbothimages.Allof4benigncaseswerenegativeinbothACandNACimages.TheratiosofT/BACweresignificantlyhigherintumorinsidethelungandsignificantlylowerintumoroutsidethelungthanthoseofT/BNAC(P0.01).ThelocationandextensionofthetumorandthelesioninthedeepregionofthebodywaseasiertorecognizeintheACimagesthanthatintheNACimages.Inallof28leftventricularmyocardialNACimages,significantattenuationartifactswerefoundinthesegmentsofseptaandinferoposteriorwalls.TheradioactivitydistributionwasmuchuniforminallthesegmentsofACimagesastheaveragetotalscoresinleftventricularmyocardiumdeceasedfrom10.82±2.14inNACimagesto3.64±2.23inACimages.ConclusionAlthoughACdidn’tincreasethedetectionrateoftumor,itcandemonstrateclearlythelocationandextensionofthetumorandthelesionsinthedeepregionofthebody,andimprovetheattenuationartifactsinthemyocardiumimaging.ThereforeAChascertainclinicalvalue.KeywordsAttenuationcorrection;Coincidenceimaging;18F-FDG;Tumor;myocardium18F-FDGSPECT[1-3]ACAC18F-FDGSPECT158140281258.8±12.32911361495142cm122cm45412cm32cm1228161258.8±13.210218F-FDGSPECT27%ADACVertexplusEPICMCD/ACSPECT18F-FDG90%14h111~185MBq18F-FDG1h1~31AC137Cs1110MBq30min6minOSEMACNAC2ACNAC18F-FDGACNACROIT/Bχ±s∼1ACT/Br15912NAC35,ACNACAC4NAC()AC()1602cm2cm1221.1%Zimny[9]AC…2cm18F-FDGSPECT/PET60%80%2cmACT/BT/BACACZimny[9]ACNAC10.82±2.14AC3.64±2.23ACACNACAC1DelbekeD,PattonJA,MartinWH,etal.FDGPETanddual-headgammacamerapositroncoincidencedetectionimagingofsuspectedmalignanciesandbraindisorders.JNuclMed,1999,40:110-117.2TatsumiM,YutaniK,WatanabeY,etal.Feasibilityoffluorodeoxyglucosedual-headgammacameracoincidenceimagingintheevaluationoflungcancer:comparisonwithFDGPET.JNuclMed,1999,40:566-573.3WeberW,YoungC,Abdel-DayemHM,etal.Assessmentofpulmonarylesionswith18F-fluorodeoxyglucosepositronimagingusingcoincidencemodegammacameras.JNuclMed,1999,40:574-578.4BengelFM,ZiegerSI,AvrilN,etal.Whole-bodypositronemissiontomographyinclinicaloncology:comparisonbetweenattenuation-correctedanduncorrectedimages.EurJNuclMed,1997,24:1091-1098.5ImranMB,KubotaK,YamadaS,etal.Lesion-to-backgroundratioinnonattenuation-correctedwhole-bodyFDGPETimages.JNuclMed,1998,39:1219-1223.6KotzerkJ,GuhlmannA,MoogF,etal.Roleofattenuationcorrectionforfluorine-18fluorodeoxyglucosepositronemissiontomographyintheprimarystagingofmalignantlymphoma.EurJNuclMed,1999,26:31-38.7ZasadnyKR,KisonPV,QuintLE,etal.Untreatedlungcancer:quantificationofsystematicdistortionoftumorsizeandshapeonnon-attenuation-corrected2-[fluorine-18]fluoro-2-deoxy-D-glucosePETscans.Radiology,1996,201:873-876.8PattonJA,TurkingtonTG.Coincidenceimagingwithadual-headscintillationcamera.JNuclMed,1999,40:432-441.9ZimnyM,KaiserHJ,CremeriusU,etal.Dual-headgammacamera2-[fluorine-18]-fluoro-2-deoxyglucose-D-glucosepositronemissiontomographyinoncologicalpatients:effectsofnon-uniformattenuationcorrectiononlesiondetection.EurJNuclMed,1999,26:818-823.