蛋白酶切位点

EnzymesE.C.NumberCleavagesitesSerineproteases（丝氨酸蛋白酶）E.C.3.4.21.α-chymotrypsin(胰凝乳蛋白酶，糜蛋白酶)E.C.3.4.21.1Tyr-|-Xaa,Trp-|-Xaa,Phe-|-Xaa,andalsoLeu-|-Xaa,Met-|-Xaa,Trypsin(胰朊酶，胰蛋白酶)E.C.3.4.21.4Arg-|-Xaa,Lys-|-Xaa,Pancreaticelastase(胰弹性蛋白酶)E.C.3.4.21.36Ala-|-Xaa,andalsoGly-|-Xaa,Val-|-Xaa,Ser-|-Xaa,Thrombin(凝血酶)E.C.3.4.21.5Arg-|-Gly,Plasmin(胞质素，胞浆素)E.C.3.4.21.7Lys-|-Xaa,Arg-|-XaaProlyloligopeptidase,orprolylendopeptidaseE.C.3.4.21.26Plasmakallikrein(血浆激肽释放酶)E.C.3.4.21.34Arg-|-Xaa,Lys-|-Xaa,includingArg-|-Ser,Lys-|-Arg,Leukocyteelastase(白细胞弹性蛋白酶),orneutrophilelastase(中性白细胞弹性蛋白酶),orlysosomalelastase(溶酶体弹性蛋白酶)E.C.3.4.21.37Val-|-Xaa,Ala-|-Xaa,Cysteineproteases（半胱氨酸蛋白酶）E.C.3.4.22.CathepsinB(组织蛋白酶)E.C.3.4.22.1Arg-Arg-|-Xaa,andalsoLeu-|-Xaa,Ala-|-Xaa,Phe-|-Xaa,Trp-|-Xaa,Clostripain(梭菌蛋白酶),orendoproteinaseArg-CE.C.3.4.22.8Arg-|-XaaincludingArg-|-Pro,butnotLys-|-XaaCalpain(钙激活中性蛋白酶)-1,orμ-calpainE.C.3.4.22.52Met-|-Xaa,Tyr-|-XaaandArg-|-Xaa(withLeuorValastheP2residue)Asparticacidproteases(天冬氨酸蛋白酶)E.C.3.4.23.Pepsin(胃朊酶，胃蛋白酶)E.C.3.4.23.1PreferentiallyPhe-|-Xaa,Tyr-|-Xaa,AndalsoLeu-|-Xaa,andTrp-|-Xaa,ideallywithXaa=Phe,Trp,orTyrCathepsin(组织蛋白酶)DE.C.3.4.23.5PreferentiallyPhe-|-Xaa,Tyr-|-Xaa,AndalsoLeu-|-Xaa,ideallywithXaa≠AlaorValMetalloproteases（金属蛋白酶）E.C.3.4.24.Neprilysin(脑啡肽酶),orenkephalinase(脑啡肽酶),orneutralendopeptidaseE.C.3.4.24.11Xaa-|-Tyr,Xaa-|-Phe,Xaa-|-Trp,andXaa-|-Leu,Thimetoligopeptidase(甲拌磷寡肽酶),orendo-oligopeptidaseA,orendopeptidase(肽链内切酶)24.15,orpz-peptidease(肠促胰酶素)E.C.3.4.24.15Xaa-|-Arg,Xaa-|-Ser,Xaa-|-Ile,Xaa-|-Ala,Xaa-|-Gly,Aminopeptidases（氨肽酶）E.C.3.4.11.N-termLeucyl-aminopeptidaseE.C.3.4.11.1PreferentiallyLeu-|-Xaa,butnotArg-|-Xaa,andLys-|-Xaa,AminopeptidaseMorN,oralanylaminopeptidase,ormembranealanineaminopeptidaseE.C.3.4.11.2PreferentiallyAla-|-Xaa,andTyr-|-Xaa,ifYaa-Pro-|-XaaintermwithYaa=Ala,Val,Leu,Ile,Phe,TyrorTrp,thenthedipeptideYaa-ProcouldbereleasedAminopeptidaseBE.C.3.4.11.6Arg-|-Xaa,Lys-|-Xaa,AminopeptidaseA,orangiotensinase,orglutamyl-aminopeptidaseE.C.3.4.11.7Glu-|-XaaAsp-|-Xaa,Dipeptidyl-peptidasesandtripeptidyl-peptidases（二肽基肽酶和三肽基肽酶）E.C.3.4.14.N-term(di-andtripeptides)Dipeptidyl-peptidaseI,orcathepsin(组织蛋白酶)CorJE.C.3.4.14.1Xaa-Yaa-|-Zaa,ifXaa≠ArgorLys,orYaa≠Pro,orZaa≠ProDipeptidyl-peptidaseIVE.C.3.4.14.5PreferentiallyXaa-Pro-|-Zaa,(butalsoXaa-Ala-|-Yaa)withYaa≠ProorHypProlyltripeptyl-peptidaseE.C.3.4.14.12Xaa-Yaa-Pro-|-Zaa,ifZaa≠ProPeptidyl-Dipeptidases（肽基-二肽酶）E.C.3.4.15.C-termPeptidyl-depeptidaseA,orangiotensin-convertingenzymeE.C.3.4.15.1Xaa-|-Yaa-Zaa,ifYaa≠ProorZaa≠AsporGluMetallo-carboxypeptidases（金属羧肽酶）E.C.3.4.17.C-termCarboxypeptidaseAE.C.3.4.17.1Xaa-|-YaaifYaa≠Asp,Glu,Arg,LysorProCarboxypeptidaseB,orprotaminaseE.C.3.4.17.2Xaa-|-ArgandXaa-|-LysCarboxypeptidaseN,orLysine(arginine),Carboxypeptidase(羧基肽酶),orkininaseI(激肽酶)E.C.3.4.17.3Xaa-|-LysXaa-|-ArgCarboxypeptidaseUorRE.C.3.4.17.20Xaa-|-ArgandXaa-|-LysGlutamateCarboxypeptidaseII,orfolatehydrolaseE.C.3.4.17.21Xaa-|-Glu,preferentiallywithXaa=AsporGlu