肿瘤转移-英文版

Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTWhatismetastasis?Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTCancerStemCells•motivateandmaintainthegrowthofcancercells•potentialityplasticitymakethemeasytosurviveHypothesisoftumormetastasisThephasesofCancermetastasisThemechanismofcancermetastasisMalignantTumormetastasispathwayThemoleculesinthemetastasis俞仁涛Invasion(侵犯)Intravasation（内渗）Extravasation（外渗）Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTInvasion1.Stablecellmovablecell2.Proteinexpression3.MovementmechanismRelativegenesDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTIntravasation1.Angiogenesis2.ImmuneescapeDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTExtravasationTheinverseprocessofinvasionTHEPROCESSOFTUMORMETASTASISDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTMalignantTumormetastasispathway恶性肿瘤常见的转移途径Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTCommonmetastasispathway1.lymphaticmetastasis淋巴道转移2.hematogenousmetastasis血道转移3.implantationmetastasis种植性转移Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTProcess：cancercelllymphvesselregionallymphnodebeyondlymphnodehematogenousmetastasis1.LymphaticmetastasizeDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXT2.HematogenousmetastasislungliverDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTMetastasispathway（1）Bodyveinlung（2）Portalveinliver（3）pulmonaryveinsTotalbody（brain、bone、kidney、adrenalglands）Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXT3.Implantationmetastasis•Chest•Celiac•PericardialcavityDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTBioremediation生物治疗LowsideeffectsWiderangeCleargoalDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTMechanismofcellmetastasis•Celladhesionmolecule(CAM)•Degradationofextracellularmatrix•Motilityoftumorcells•Formationofvessels•Regulationofgeneexpression•ImmunizationDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTCelladhesionmolecule(CAM)CadherinIntegrinsSelectinIgSFothersDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDegradationofextracellularmatrixDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXT丝氨酸蛋白酶类半胱氨酸蛋白酶类（Caspase家族）天冬氨酸蛋白酶类基质金属蛋白酶类（MMPs）DegradationofextracellularmatrixProteoiyticenzymes(蛋白水解酶)—溶解ECMECM是肿瘤侵袭和转移的天然屏障Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTMotilityoftumorcellsMotilitytypes:RandommovementDirectionalmovementMotilityfactors:AutoecrineparacrineDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTFormationofvesselsTumormetastasisrelysontheformingofvessels.BriefIntroductiontoMoleculesinCancerMetastasisThreeSectionsTumourangiogenesisDisaggregationIntravasationDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTTumourangiogenesisTumourangiogenesishaslaidthefoundationfortumoursurvivalandtumourmetastasis.Designer:S.G.C.chen8332海.水.正.蓝.作.品NEXTTumourangiogenesisActivatedGeneCytokines:VEGF&TNFAdhiesionmoleculesDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDisaggregationBrokendownDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDisaggregationUpaCathepsinsMMPsDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTDisaggregationDiminishedadhesivenessProteolyticenzymesDisaggregationDesigner:S.G.C.chen8332海.水.正.蓝.作.品NEXTIntravasation