中药质量控制的现状与发展

,][1.[M].:,1999,3.[2]W.Zhu.etal.PharmaeokineticofRheininHealthyMaleVolunteersFollowingoralandRetentionEnemaAdministrationofRhubathExtraet:ASingleDosestudy[J].Am.J.Chin.Med.2005,33(6):839850.[3]Tan,L,YS.Yuan,J.W.YangandQ.Qiu.DeternunationofrheininhumanPlasmabyHpLCandthestUdy0fitsPharmaeokineticsIJ].Bull.JinlingHosP.1988,11:112115.[4],,...2011,33(l2):20732075.5],,.[J]..2010,30(11):911915.()ResearchingideasofTCMPharmaeoldnetiesPENGLOng,GAOXiaoyan*,GUOMingxing,SUJiankun(CenterofscienterientBengUniversitrofChinesediclne,BeijingIO02)IAbstraetTherearemainlytwoideasonthePharmaeokinetiestudyoftraditionalChinesemedieines:integralPharmaeokinetiestudyofmultiPleeomPonentsanddeterminepharmaeokineticmarkers.InthisPaper,theresearchingmethodscommonlyusedandtheirProblemsonthePharmacokinetiestudyofTCMarereviewed,anda150eomParisonofthetwoideasofTCMPharmaeokineties.IKeywordslTCMPharmaeokineties,inte1Pharmaeokinetie,pKmarkers,,,,(,330004)l]:,1,,,,,,l:;;,,,,,,::N().2()l()()7012):(1952),(),_,_,.::390809786:gongql2002@163,eo2:(1987,(),,1,.}.::1507082305f:i)1087026.e212l(),(),,:GLPGMPGCPGSPGAP,,,,,,,2,,,,,,,,,,,,,,,l2]:¹,,,;º,;»,,131:¹,º,,,»,,¼,,33.1,,(l),,,,,,,,,,,,,(3),,,,,(2),,,,,,,3.2,(),,,I4]:,,,,,,,,;,,,(),,,[5]4(),,,4.1161,,,,4.2[,,:,,,;_,,4.3,,l8],,,,4.4,,,4.54.5.1[9],,,,,,4.5.201,,,,,,,,4.5.3,,,,,,,4.5.4,,,,,,2],,(),()4.5.5,,,,,,4.5.6,,,,5,,,,,,215[]:1,,.J.,2009,12(5):805.2],.J].,2007,32(14):13771381.[3j,J].,2006,4(9):332337.4j.J,2011,17(12):249~252.5],..J].,2012,37(6):865870.(),,*,(,5106),,,,,ll,,,,,,,,,,,,1.,,,,,,2.,,,,,,,,,,,3.,,,,,,,,