褪黑素在胃溃疡中的保护作用及其机制的研究进展

20076273IntJDigDis,June25,2007,Vol.27,No.3(MT),,,,,,;;ProtectionofmelatoninagainstgastriculceranditsmechanismCHENJian2yong,SHENXue2wen,ZHANGJi2xiang.De2partmentofdigestion,theSecondAffiliatedHospitalofNanchangUniversity,Nanchang(330006),ChinaAbstractMelatonin(MT)isakindofneuroendocrinehormoneinhuman.Thepreviousstudieshaveshownthatithasstronganti2oxygenactivity,directlycleaningoxyradicalandstrengtheningactivityofoxidase.Inrecentyears,theprotectionandreparationroleofMTingastriculcerhasbeenstudiedwidespreadandreceivedinitialresults.KeywordsGastriculcer;Melatonin;Mechanism:(30360037);:330006:E2mail:[e-mail](MT)N225,L21959Lerner,,Jauorek[1]MT,Cevik[2],,,,(Hp)(NSAID),,,,1,,,Bubenik[3],,10100,,Bubenik52,,,,,,22.1,,,,,NSAIDHp,Sener2Muratvghi[11],,2.222(MMP)1962GrossLapiere,,MMP20,MMP49120076273IntJDigDis,June25,2007,Vol.27,No.3,,MMP22,MMP,,Ganguly[4],,MMP22,,MMP,MMPMaity[425],MMP22,,MMP22,Ganguly[6]H2O2,H2O2MMP22,(ROS),MMP22,,MT12MMPTIMP2MMP22,,MMP22,,3,,,,,,,H+,,,,,,,Brzozowski[7],,,(WRS),,MT2222N2,,1.2510mgkg-1d-11.2510gkg-1d-1,WRS,(GBF),PGE2NO222N2,,,Brzozowska[8]:,2122(COX21COX22),,N22L2NO,,90%PGE2,(CGRP),N22L2NO,WRS,,,COX22PGE2NOCGRP,PGE2NO,CGRP,(IGF),,,,,MT2,Jauorek(),4,,,Bandyo2padhyay[9210]WRS,,,Sener2Muratoglu[11],,,5,,MMP22,,,MT2,,,,,,,59120076273IntJDigDis,June25,2007,Vol.27,No.3,,,,,,1JaworekJ,BrzozowskiT,KonturekSJ.Melatoninasanorgan2oprotectorinthestomachandthepancreas.JPinealRes,2005,38:732832CevikH,ErkanliG,ErcanF,etal.Exposuretocontinuousdarknessamelioratesgastricandcolonicinflammationintherat:bothreceptorandnon2receptor2mediatedprocesses.JGastroen2terolHepatol,2005,20:29423033BubenikGA.Localization,physiologicalsignificanceandpossi2bleclinicalimplicationofgastrointestinalmelatonin.BiolSig2nalsRecept,2001,10:35023664GangulyK,MaityP,ReiterRJ,etal.Effectofmelatoninonsecretedandinducedmatrixmetalloproteinase29and22activityduringpreventionofindomethacin2inducedgastriculcer.JPine2alRes,2005,39:30723155LempinenM,InkinenK,WolffH,etal.Matrixmetalloprotei2nases2and9inindomethacin2inducedratgastriculcer.EurSurgRes,2000,32:16921766GangulyK,KunduP,BanerjeeA,etal.Hydrogenperoxide2mediateddownregulationofmatrixmetalloprotease22inindom2ethacin2inducedacutegastriculcerationisblockedbymelatoninandotherantioxidants.FreeRadicBiolMed,2006,41:91129257BrzozowskiT,KonturekPC,Zwirska2KorczalaK,etal.Im2portanceofthepinealgland,endogenousprostaglandinsandsensorynervesinthegastroprotectiveactionsofcentralandpe2ripheralmelatoninagainststress2induceddamage.JPinealRes,2005,39:37523858BrzozowskaI,KonturekPC,BrzozowskiT,etal.Roleofprostaglandins,nitricoxide,sensorynervesandgastrininac2celerationofulcerhealingbymelatoninanditsprecursor,L2tryptophan.JPinealRes,2002,32:14921629BandyopadhyayD,GhoshG,BandyopadhyayA,etal.Melato2ninprotectsagainstpiroxicam2inducedgastriculceration.JPin2ealRes,2004,36:195220310BandyopadhyayD,BandyopadhyayA,DasPK,etal.Melato2ninprotectsagainstgastriculcerationandincreasestheefficacyofranitidineandomeprazoleinreducinggastricdamage.JPine2alRes,2002,33:12711Sener2MuratogluG,PaskalogluK,ArbakS,etal.Protectiveeffectoffamotidine,omeprazole,andmelatoninagainstacetyl2salicylicacid2inducedgastricdamageinrats.DigDisSci,2001,46:3182330(:2006211220)(:)(187)70%,40%[13],,,1RustgiAK.Smallintestinalneoplasms.In:FeldmanM,Fried2manLS,SleisengerMH(eds):SleisengerandFordtran’sGas2trointestinalandLiverDisease7thed.Philadelphia:WBSaun2ders,2002,2169221722GillSS,HeumanDM,MilhasAA.Smallintestinalneoplasms.JClinGastroenterol,2001,33:26722823YangYS,HuangQY,WangWF,etal.Primaryjejunoilealneoplasmas:areviewof60cases.WorldJGastroenterol,2003,9:86228644..,2002,7:9921005,,,..,2005,25:88028826,,,.342.,2005,10:152197WoldPB,FletcherJG,JohnsonCD,etal.AssessmentofsmallbowelCrohndisease:noninvasiveperoralCTenterographycomparedwithotherimagingmethodsandendoscopy22feasibilitystudy.Radiology,2003,229:27522818RomanoS,DeLutioE,RollandiGA,etal.Multidetectorcom2putedtomographyenteroclysis(MDCT2E)withneutralenteralandIVcontrastenhancementintumordetection.EurRadiol,2005,15:1178211839BoudiafM,JaffA,SoyerP,etal.Small2boweldiseases:pro2spectiveevaluationofmulti2detectorrowhelicalCTenteroclysisin107consecutivepatients.Radiology,2004,233:338234410MatsuokaH,TakaharaT,MasakiT,etal.Preoperativeeval2uationbymagneticresonanceimaginginpatientswithbowelob2struction.AmJSurg,2002,183:614261711FleischerDE.Capsuleendoscopy:thevoyageisfantastic22willitchangewhatwedo.GastrointestEndosc,2002,56:452245612,,,..,2004,24:741274413,.54.,2005,10:1772178(:2006211230)(:)691