妊娠期易栓症的处理

1mg/kg,121332,,(150mg/d),333K,,CE,3341(VTE),,LMWH(UFH),VTE,VTE,LWMHUFH,VTEAPL,,(3)VTE,UFH,LMWH1,UFHLMWHFGR,,,,FGR,,,,[1]GinsbergJS,HirshJUseofantithromboticagentsduringpregnancy[J].Chest,1995,108(4):305-311[2]GreavesM,CohenH,MacHinSJ,etalGuidelinesontheinvestigationandmanagementoftheantiphospholipidsyndrome[J].BrJHaematol,2000,109(4):704-715[3]BatesSM,GreerIA,PabingerI,etalVenousthromboembolism,thrombophilia,antithrombotictherapy,andpregnancy:americancollegeofchestphysiciansevidencebasedclinicalpracticeguidelines(8thedition)[J].Chest,2008,133(6):844-886(:20081224):1003-6946(2009)03-142-03林建华,沈瑶(,200127):R714254:B(thrombophilia),,(SLE)(APS)(FGR),,,(LMWH);,;,,,1;;!,3,;∀(SLE);#(APS);∃,FGR;%,,221LMWH&142&20093253JournalofPracticalObstetricsandGynecology2009Mar.Vol.25,No.3211∋,:;;!,,,,(FDA)C,,[1]212LMWH(UFH)∋(AT∋),UFH,4000~6500d,(98%),(APTT),,,LMWH,LMWH,,LMWHLMWHGreer[2]200324,2777,LMWH,,086%(CI055%~128%)05%(CI028%~084%)198%(CI134%~257%)18%(CI134%~275%)011%(CI002%~02%)004%(CI001%~02%),FDAB,,,[1]213,,K,K,,,,,;,FDAD,,,,,22,[2],,,,FDAC,,,23,,,2445%,4%(rtPA),,1%~2%3,,LMWH,,,,(),;(G20210A),,,,;[3];LMWH5000U12180mg,LMWH5000U140mgLMWH,,&143&20093253JournalofPracticalObstetricsandGynecology2009Mar.Vol.25,No.3LMWH,LMWHLMWH25mg(75~100mg),,,,LMWHD(DD)03~05mg/L,DD03mg/LPT15~2(PTA)35%~50%,[INR=(PT/PT)(ISI]15~20(20~30),,3LMWH,13~36,LMWH4,,,,,,,,(DVT)DIC,:,K,3,6~12LMWH,(PCCs)24,LMWH,,3,3,INR5,,,,,,,3DVT,,,DVT6~10U/d,2~3,1~2,7~10,,,,,,,120U,3~5,,,,,,[1]PeterR,MargaretRPrescribinginpregnancy[M].Anticoagulantsinpregnancy4sted.Edition:UK,2008:56-71[2]GreerIA,NelsonPCLowmolecularweightheparinsforthromboprophylaxisandtreatmentofvenousthromboembolisminpregnancy:asystemreviewofsafetyandefficacy[J].Blood,2005,106(2):401-407[3]CLASP(collaborativelowdoseaspirinstudyinpregnancy)collaborativegroupArandomizedtrialoflowdoseaspirinforthepreventionandtreatmentofpreeclampsiaamong9364pregnantwomen[J].Lancet,1994,343(12):619-629(:20081216):1003-6946(2009)03-144-03应豪,段涛(,200040):R714254:B,024/~051/:,Email:tduan@yahoocom&144&20093253JournalofPracticalObstetricsandGynecology2009Mar.Vol.25,No.3