几家代表性医院检验科现开展检验项目

几家代表性医院检验科现开展检验项目•JohnsHopkinsMedicalLaboratories项目简介•华西医院检验科项目简介•协和医院检验科项目简介•中山达安基因项目简介•肿瘤个体化用药常用项目简介•我的思考•JohnsHopkinsMedicalLaboratories•600NorthWolfeStreet•MeyerB-130•Baltimore,MD21287-7070•Phone[phone]•Fax[phone]JHMLServices•BloodDisorders&SpecialCoagulation临检和凝血•ClinicalChemistry生化•Cytokine细胞因子•HIVSpecialtyServicesHIV筛查•Immunology免疫•MedicalMicrobiology医学微生物•MolecularPathology&Cytogenetics分子病理和细胞基因•NeoplasticHematopathology&FlowCytometry血液病理和流式细胞仪•TransfusionMedicine血库CardiovascularPanel心血管项目组合Testabnormalitiesinthispanelcorrelatewithanincreasedriskofcardiovasculardisorders.FactorVIIActivityFibrinogenActivityHomocysteine(specialcollection)Lipoprotein(a)PlasminogenActivatorInhibitor-1(PAI-1)ProthrombinFragment1.2TissuePlasminogenActivatorAntigenCirculatingAnticoagulantandLupusAnticoagulant循环抗凝和狼疮抗凝•Abasicscreeningpanelforfactordeficienciesandthedetectionofinhibitors.APTTMixingStudies(APTT)MixingStudies(PT)PT(ProthrombinTime)PlateletNeutralizationd-RVVT,withconfirmAnti-cardiolipenAntibody,IgG,IgM,IgAAnti-B2GP1antibodies,IgG,IgM,IgAAbnormalPTand/orAPTTEvaluation一般凝血检查•Thispanelisusedtoevaluatethecauseofanabnormalprotimeoractivatedpartialthromboplastintime.APTTAPTTMixingStudiesHepzyme(Testforheparincontamination)PT(ProthrombinTime)PT(ProthrombinTime)MixingStudiesPlateletNeutralizationDDAVPChallenge血管加压素耐受性•ThepanelisusedtoevaluatetheresponseofmildhemophiliaandvonWillebranddiseasepatientstoDDAVP.FactorVIIIActivityRistocetinCoFactorassayWFAntigenHEME-8(pre-post)DICScreenDIC筛查•TheDICscreenisusefulinthediagnosisandfollow-upofdisseminatedintravascularcoagulation.APTTD-dimer(Quantitative)FibrinogenProthrombinTimeExtrinsicPathwayPanel外凝血通路组合•Panelusedtoevaluateandidentifythecauseofanabnormalprothrombintime.FactorVIIActivityFactorXActivityFactorVActivityFactorIIActivityIntrinsicPathwayPanel内凝血通路组合•Panelcanbeusedtoevaluateandidentifythecauseofanabnormalactivatedpartialthromboplastintime.FactorXIIActivityFactorXIActivityFactorIXActivityFactorVIIIActivityFibrinolysisPanel纤维蛋白溶解组合•Thefibrinolysispanelmaybeusedtomonitorordiagnoseacquiredorcongenitalabnormalitiesofthefibrinolyticsystem.alpha-2-AntiplasminD-dimerQuantitativeFibrinogenDegradationProductsPlasminogenActivatorInhibitor-1(PAI-1)PlasminogenActivityTissuePlasminogenActivatorAntigenLupusAnticoagulant(AntiphospholipidScreen)狼疮抗凝(抗磷脂筛查•Abasicscreeningpanelforthedetectionoflupus-likeinhibitors.TheprofilemayalsobeusedforpatientswithanunexplainedprolongedprothrombintimeorAPTT.AnticardiolipinAntibody(ELISA)APTTandMixingStudiesD-RVVT(DiluteRussellViperVenom)andMixingStudiesPT(ProthrombinTime)andMixingStudiesPlateletNeutralizationTestifevidenceforaninhibitorPlateletFunctionPanel血小板功能组合•Panelusedtoidentifyplateletfunctionproblems.PFA-100BleedingTimeClotRetractionPlateletAggregationPlateletSecretion(ATPrelease)FlowcytometrystudiesifindicatedProthrombinConsumptionTestThromboticRiskPanel血栓风险组合•Thethromboticriskpanelisacomprehensivegroupoftestsforevaluatingpatientswithhypercoagulablestates.ActivatedProteinCResistanceandFactorVLeidenAntithrombinIIIActivityDiluteRussell'sViperVenom(D-RVVT)FibrinogenActivity,FibrinogenAntigenHomocysteine(specialcollection)Lipoprotein(a)LupusAnticoagulantScreenPlasminogenActivatorInhibitor1(PAI-1)PlasminogenActivityCActivityProteinCAntigenProteinSActivityProteinSAntigenTotalThrombinTimeTissuePlasminogenActivatorAntigenProthrombinGeneMutationThromboticRiskScreen血栓风险筛检•Agroupofbasictestsusedtoscreenpatientsforonlythemostcommoncausesofthrombosis.ActivatedProteinCResistanceAntithrombinIIIActivityD-RVVTHomocysteine(specialcollection)ProteinCActivityProteinSActivityvonWillebrandPanel血管性血友病因子•ThispanelisfortheevaluationofsuspectedvonWillebranddisease.APTTFactorVIIIActivityRistocetinCofactorvWFAntigenvWFMultimersasneeded•MarkersofHyper-Coagulation高凝状态标志物•Prothrombinfragment1,2Plasmap-SelectinThromboxaneBeta-ThromboglobulinPF4•MiscellaneousBleedingDisorders各种出血紊乱•FactorXIIIActivityProteinTests特种蛋白•CryoglobulinScreenwithreflextoimmunofixationelectrophoresisforpositives•CSFIgGIndexbynephelometry•CSFIgG(IgG/TotalProteinas%)•Electrophoresis,Protein,serum•Electrophoresis,Protein,serumwithimmunoglobulinquantitationsandimmunofixationelectrophoresis•Electrophoresis,Protein,24-hoururineorrandomurine:includestotalprotein•Electrophoresis,Protein,24-hoururineorrandomurine:includestotalprotein,immunoglobulinquantitationsandimmunofixationelectrophoresis•Electrophoresis,BenceJonesProtein,24-hoururineorrandomurineincludestotalproteinandimmunofixationelectrophoresis•Haptoglobinbynephelometry•IgA,Serumbynephelometry•IgG,Serumbynephelometry•IgM,Serumbynephelometry•PrealbuminbynephelometryAutoimmuneDiseaseTests自身免疫•ANAScreenwithreflextotiterandpatternforpositivesbyIFA•C3bynephelometry•C4bynephelometry•CyclicCitrullinatedPeptide(CCP)IgGbyEIA•dsDNAScreenwithreflextotiterforpositivesbyIFA•Jo-1antibodybyEIA•MitochondrialantibodywithreflextotiterforpositivesbyIFA•RheumatoidFactorbynephelometry•Sclerodermaantibody(Scl-70)byEIA•Sjogren’santibody(SS-A)byEIA•Sjogren’santib