围生期孕妇生殖道B族链球菌感染与耐药性分析-刘丽

[e-mail]121.2570912.257447BGBS。795GBS。795GBS25632.20%。＜3028.88%≥3042.35%P＜0.01。GBS18.75%、7.98%P＜0.01、、100%～58.1%D-23.9%。GBSGBS、、、、89.8%～100.0%。BＲ714.7Ｒ446.5ADOI10.11851/j.issn.1673-1557.2016.04.009http//．cnki．net/kcms/detail/51．1688．Ｒ．20160624．1117．006．htmlGroupBStreptococcusInfectioninGenitalTractofPerinatalPregnantWomenanditsDrugＲesistanceAnalysisLIULi1YANGWendong21.MaternalandChildHealthCareofFamilyPlanningServiceCenterofDongyingDistrictShandongDongying257091China2.SecondPeople’sHospitalofLijinCountyDongyingShandong257447ChinaAbstractObjectiveToanalyzethegroupBStreptococcusGBSinfectioningenitaltractofperinatalpregnantwomenanditsdrugresistanceandtoprovideareferencefortreatingandpreventingthisinfection．MethodsFromJanuary2013toFebruary2015thevaginalsecretionsweresampledfrom795perinatalpregnantwomenforcultureofGBSthefinalresultswerestatisticallyanalyzed．ＲesultsIn795pregnantwomentherewere256GBScarriersthegerm-carryingratewas32.20%．Therewasasignificantdifferenceinthegerm-carryingratebetween＜30yearsoldgroup28.88%and≥30yearsoldgroup42.35%χ2=19.095P＜0.01．TheincidenceofclinicalsymptomsbetweenGBSnegativecasesandGBSpositiveones18.75%7.98%alsohadstatisticaldifferenceχ2=39.514P＜0.01．TheantimicrobialresistantrateofvancomycinlinezolidpenicillinampicillinceftriaxonenitrofurantoinlevofloxacinclindamycinerythromycinandtetracyclinetoGBSwas000.6%3.1%6.6%9.6%21.9%23.8%29.9%and58.1%respectively．ThepositiverateofD-bacteriostaticringtestwas23.9%．ConclusionTheGBS-carryingrateofperinatalpregnantwomenishigherinthisregionandtheelderlyisrelativelyvulnerable．GBSarehighlysensitivetovancomycinlinezolidpenicillinampicillinceftriaxoneandnitrofurantoininperinatalpregnantwomen．KeywordsgroupBStreptococcusGBSperinatalpregnantwomengerm-carryingratedrugsensitivetestBgroupBStreptococcusGBSβ。GBSGBS。GBS1。GBS、2、、、GBS3。。GBS。462lcykw.com.cn11.12013120152795。35～3721～38≥30196＜30599。2。。1.25%Mueller-HintonMHVITEK2、、、、、、、、。ATCC49619。D-OXOID15μg2μg。1.321/330min。35℃5%CO218～24h。、。、、。42012ClinicalandLaboratoryStandardsInstituteCLSIM100-S225。GBSD-MH12mm35℃5%CO220～24h。1.4SPSS19.0χ2。22.1GBS795GBS25632.20%。256GBS＜30173≥3083＜30GBS28.88%173/599≥30GBS42.35%83/1962χ2=19.095P＜0.01。2.2、31GBS。256GBS4818.75%539GBS437.98%χ2=39.514P＜0.01。2.3GBS256GBS101。、、、、89.8%～100.0%。1256GBS/%/%/%100.00.00.0100.00.00.099.40.00.696.90.03.193.40.06.689.80.69.669.98.221.960.216.023.848.821.329.918.923.058.12.4D-256GBS、7117D-23.94%。3GBS。。GBS、6-7。、GBS3。GBSGBSGBS。GBSGBSGBS。2。FQ-PCＲGBS、8-10。GBS。GBS。GBS、、、、。7.10%113.70%127.50%13、8.76%14、5629.50%15、4.2%16。79532.2%36.0%17。≥30GBS＜30≥30＜30、、。≥30GBS。GBS。GBS18。G、GBS18。256GBS100%～58.1%。、、、、89.8%～100.0%、、18.9%～69.9%19-20。GBS、、GBS。21GBS。GBSGBS、、、、GBS。GBSGBS。1．J．2012304389-391.2．J．2013286142-143146-147.3LIVENGOODCH．Bacterialvaginosisanoverviewfor2009J．ＲeviewsinObstetricsandGynecology20092128-37.4．BJ．201045112-16.5ClinicalLaboratoryStandardsInstitute．PerformancestandardsforantimicrobialsusceptibilitytestingS.2012MS22-M100.6．BJ．201342101184-1185.7．BJ．201426111356-13581361.8．PCＲBJ．2012276102-104.9．BJ．201328187-89.10PAＲKJSCHODHYANGJHetal．Usefulnessofarapidreal-timePCＲassayinprenatalscreeningforgroupBstreptococcuscolonizationJ．AnnalsofLaboratoryMedicine201333139-44.11．477J．2011292155-156.12．BJ．2009322128-130.13．BJ．201334152006-2007.14．BPCＲJ．2013487581-584.15．35～37BJ．2013144312-314.16．PCＲBJ．2014296628-630.17．BJ．201328587-8892.18VEＲANIJＲMCGEELSCHＲAGSJetal．PreventionofperinatalgroupBstreptococcaldisease-revisedguidelinesfromCDC2010J．MMWＲ．ＲecommendationsandＲeportsMorbidityandMortalityWeeklyＲeport．ＲecommendationsandＲeports/CentersforDiseaseControl201059ＲＲ/101-36.19．BJ．2011454434-435.20．BJ．2010459701-703.21．J．201530113-16.2015-09-06662