多囊卵巢综合征肾虚动物模型及中医药干预研究进展-吕宣宣

35720177CHINESEAＲCHIVESOFTＲADITIONALCHINESEMEDICINEVol．35No．7Jul．20171817DOI10．13193/j．issn．1673-7717．2017．07．04912211．3100532．310007polycysticovariansyndromePCOS、、1。PCOS。PCOS。Ｒ711．75A1673-7717201707-1817-04ProgressonAnimalModelsofPolycysticOvarySyndromewithDeficiencyofKidneyandInterventionwithTraditionalChineseMedicineLYUXuanxuan1FUPing2XINGJia2CHENTingting11．ThirdClinicalMedicalCollegeofZhejiangChineseMedicalUniversityHangzhou310053ZhejiangChina2．GynecologyofTCMHangzhouHospitalofTraditionalChineseMedicineHangzhou310007ZhejiangChinaAbstractPolycysticovarysyndromePCOSisadiseasewithhigherincidenceofreproductiveendocrinology．Itsclinicalfeaturesincludeandrogenexcesschronicanovulationhistologicalexaminationofovaryrevealspolycysticchan-geswithinsulinresistanceandobesity．InrecentyearstheincidenceofPCOSisincreasing．Itisnecessarytosetupeffe-vtiveanimalmodelswiththecombinnationofdiseaseandsyndromeandfurthertostudythecorrelationalresearchofP-COS．Inthisarticletheauthorswouldintroducesomemethodsofestablishinganimalmodelswiththesyndromeofdefi-ciencyofkidneyofPCOSandreviewtheeffectsofTCMontheinterventionofPCOS．KeywordspolycysticovariansyndromedeficiencyofkidneyanimalmodeltraditionalChinesemedicine2017－02－092014202015ZA158HX201502－140203GZS20120231988－。1954－、。[e-mail]。PCOS、、、、、。“”“”“”“”“”“”。PCOS、、2、、、。PCOSPCOS。1PCOS1．1PCOS39SD1．25mg0．05mL/2。、、。4SD5mL·kg－1·d－114d、。1．2PCOS5DHEASTZ23ICＲ9mg/100gDHEA0．1mL“”20d12h120mg/kgSTZ0．1mL/10g114dE2T、LH。、FBG、FINS、HOMA－IＲ718135720177CHINESEAＲCHIVESOFTＲADITIONALCHINESEMEDICINEVol．35No．7Jul．20171818“”PCOS。6SDovariancystsOCCHO、TGLDL－C、OC、OC。7PCOS、、PCOSHCGPCOS231mL100g/dHCG0．15mL/228d。1．3PCOS、PCOS8。9SD50450mg/kg·d5mL/kg8d5mL/kg41h10%、、。10“”PCOSHCGPCOSSDHCG1．5IU2INS0．5U/d6．0U/d22d5%23。1．4PCOS《》“”。11－PCOS。SD、36130min1%2mL/kg1%0．5mg/kg21d。Man-ner·s12letrozolePCOS。“”。、、。13ICＲ24h、24h、、31℃1h、42℃5min、8℃5min、24h、24h、1h160/min、24h10130d3。2PCOSPCOS2080。、、P-COS。H－P－O。2．1PCOS14－15。16I、、、、、、、、PCOSPCOS、。PCOSIＲ。17、、、、、、PCOSPCOSP-COS。18、、、、、、、、、PCOST、LH、FSH、LH/FSH。19PCOSHOXA10PCOS。2．2PCOS20、、、、、、、、、PCOSLH。21、、、、、、、、PCOSⅣ、。2210g10g10g10g10g10g10g10g10g15g818135720177CHINESEAＲCHIVESOFTＲADITIONALCHINESEMEDICINEVol．35No．7Jul．2017181915g20g20g－αTNF－α、TNFＲ1、TNFＲ2T、LH、LH/FSH。2．3PCOS23、、、、P450aromPAI－1INSINSLHH－P－O。24、、、、、、、、PCOSIＲ、PCOST、LH、INSSHBG－－。2520g8g8g8g5g8g8g8g3g8g3g3gPCOSE2。2．4PCOS26PCOS、、。14。12。。2．5PCOSPCOSIＲ。27、、、、、、、、、、、Poretsky28。PCOS、、PI3KmＲNA、、。。2930g30g18g9g12g12g。TG、TCLDLTFinsHDLFSHISI。IＲ。3015g15g9g9g9g6g3g3gPCOS。PCOS。3PCOS。PCOSPCOSPCOS。、、、PCOS、“”PCOS、、、、PCOS、。PCOS。1．M．8．2013359．2．M．200523－25．3．Smad4J．201481812－1814．4．D．2012．5．J．2015102367－23698．6．J．201472157－2161．7．J．20143118－120．8S．198333．9．1D．2014．10．D．2006．11．D．2011．12MannerLCajanderSHolmngAetal．Anewratmodelexhibit-ingbothovarianandmetaboliccharacteristicsofpolycysticovarysyndromeJ．Endocrinology200714883781－3791．13．J．2016158－62．14．IIJ．200219370－71．918115．32J．200344139－41．16．ⅠPCOS、J．20093189－191．17．J．2006131038－39．18．D．2014．19．J．201329121052－1056．20．J．2013452－53．21．PCOSJ．201541284－1287．22．－αJ．2013453161－164．23．PCOP450aromPAI－1J．200831235－37．24．J．201512222－224．25．D．2011．26．J．2016180－81．27．PCOSJ．2015355361－365．28PoretskyLClemonsJBogovichK．HyperinsulinemiaandhumanchorionicgonadotropinSynergisticallypromotethegrowthofovarianfollicularcystsinratsJ．Metabolism1992418903－910．29．J．201538529－36．30．J．201587790－793．35720177CHINESEAＲCHIVESOFTＲADITIONALCHINESEMEDICINEVol．35No．7Jul．20171820DOI10．13193/j．issn．1673-7717．2017．07．0501221．1500402．150040PCOSPCOS。201212—201512PCOS460139、116、139、66255205。1、、P＜0.052P＞0.052、、、、4P＜0.05P＞0.05χ2=6．31P＜0.05χ2=4．89P＜0.05χ2=5．86P＜0.05χ2=4．7P＜0.05。PCOSPCOSPCOSPCOS、。Ｒ711．75A1673-7717201707-1820-03ConstitutionDistributionCharacteristicsofPolycysticOvarySyndromeBetweenDifferentTCMTypesLIUYinghua1HOULihui2XUFang22017－02－12—201207001JDZX20120392014－091988－。1951－、。[e-mail]。0281