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1.geneDNAGene1909WilhelmJohannsenfactor2.3.genomeeditingDNADNADNADNA4.BLASTBasicLocalAlignmentSearchToolDNA5.6.ADP7.L-WLander-Waterman1988EricLanderMichaelWatermanreadsGLLander-WatermanL-WcontigGreadsN8.LiquidBiopsyDNA9.miRNA:miRNARNA10.N50contigsscaffolds50%contigscaffoldN50N5011.STR:DNA26bp50100bpShortTandemRepeatSTR)A-TDNA12.HLAHLAHLA6p21.313.6Mb13.SNPsinglenucleotidepolymorphismDNA14.DNA:DNA(lowcopynumber,LCN)15.Alignment16.SBS:SBSDNASanger-ddNTP17.KEGG:KEGG()()Kanehisa199518.iPSoct4c-mycsox2klf4ESembryostemipsipsEB19.20.e-PCRelectronicPCR,e-PCR,,DNA(querysequence)(SequenceTaggedSit,STS),STSDNA21.ImmuneRepertoiresequencing(IR-SEQ)T/BPCR5RACEBBCRTTCRCDR22.DNA23.24.(linkagedisequilibrium)25.DNA(53355326.Synthia(Mycoplasmamycoides)DNADNA1SynthiaSynthia()1027.PGTPreimplantationGeneticTesting,DNA28.CRISPRCRISPRCRISPR29RFLPRestrictionFragmentLengthPolymorphism,DNARFLP30.GenomeDNADNA31.(pseudogene)DNA,,32.K-merK-merKDNAKK-merK-mer33.CCCCC-valueparadox34.CpGCpGDNACpGCpGisland70%90%CpGCpGCpG35.LodLodLod0LodLod36.ChIP-Seq(ChromatinImmunoprecipitationChIP)DNAChIP-SeqChIPMPHChIP-SeqDNADBP37.38.39.AssemblycontigscaffoldDNA40.RNA(Non-codingRNA)RNArRNAtRNAsnRNAsnoRNAmicroRNARNARNA41.42.overlappinggeneDNADNA43.DNA44.45.b-PCR:boosterPCRPCRPCR46.MPHMassivelyParallelHigh-thriughput,47.denovosequencing4849.50.6.DNA,DNADNAA-DNAB-DNAZ-DNADNADNADNADNADNADNADNA;;;DNA1.1DNADNADNA3,5-55-Pi33-OHDNA1.2DNADNADNAABCZ50R.FranklinM.WilkinsDNAX-ChargaffWatsonCrickDNADNAB-DNADNAB-DNA92%X363.4nmDNADNADNADNAA-DNA65%-75%1130B-DNAA-DNADNARNARNADNAAC-DNALi+66%C-DNA9.3Z-DNA124.5nmB-DNAZ-DNAZ-DNADNADNADNADNAB-DNADNA1.3DNADNADNADNADNADNA3HPuHPyDNAPu-Pu-PyPy-Pu-PyPy-Pu-PyTTCGDNAG-quadruplexi-motifG-quadruplexG-G-i-motifCC+CCCC+DNADNA2.1SBCSBSSBC1977MaxamGilbertMaxam-GilbertmethodDNA5DNA5DNADNASBS1997SangerddNTPdNTP3-OHDNAdNTPddNTPddNTPDNADNASBSSBCSBS801986LeroyHoodddNTPABIABI370AABI3773732.2Roche/454GSFLXIllumina/SolexaGenomeAnalyzerHelicosBioSciencesHeliScope?SingleMoleculeSequencerDanaherMotionPolonator(sequencingbyligation)AppliedBiosystems/SOLiD?systemIlluminaDNA100~200bpBstPCRDNADNA1000DNASanger4dNTP10DNADNAdNTPdNTP2.3PCRPacBioSMRTDNADNADNADNA1..DNA[J].,1999,(04):8-10.2.,,.DNA[J].,2004,(09):22-24.3..DNA[D].,2012.4.,,,.DNA..2015,35:811-816.5..DNA.2012,47:14-17.6.MaxamAM,GilbertW.Sequencingend-labeledDNAwithbasespecificchemicalcleavages.MethodsEnzymol,1980,65:499-560.7.MatthewW.AndersonandIrisSchrijver.NextGenerationDNASequencingandtheFutureofGenomicMedicine.Genes2010,1,38-69;doi:10.3390.8.,,,,.[J].,2017,(01):43-45+42.
本文标题:基因组学考试答案
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