肺癌患者IL-6与TNF-α测定及临床意义

IL-6TNF-α233004-6IL-6-αTNF-α3621IL-6TNF-αIL-6TNF-αP0.002P0.001IL-6TNF-αP0.05IL-6TNF-αP0.05IL-6TNF-α-6-αR734.2R730.43A1005-8664200204-0038-02-6-α1IL-6TNF-α3619993~200022313318891314241239TNMⅡ7Ⅲa7Ⅲb15V73ml-30࠷4࠷30005minIL-6TNF-αγXH-6010tIL-6TNF-αP0.002P0.00112001-06-151973-IL-6TNF-αP0.0523IL-6TNF-αP0.0541IL-6TNF-α-X+SnIL-6pgmlTNF-αngml36131.82+38.401.34+0.2821102.29+38.770.96+0.27T-3.424.97P-0.0020.0012IL-6TNF-α-X+SnIL-6pgmlTNF-αngml12120.69+41.561.41+0.289144.38+27.851.33+0.3415138.86+43.561.27+0.23F-1.0130.779P-0.050.05MS-1702.090.083IL-6TNF-α-X+SnIL-6pgmlTNF-αngmlⅡ7120.50+42.011.46+0.04Ⅲa7129.05+48.521.28+0.12Ⅲb15136.19+35.691.27+0.29V7123.83+26.361.37+0.26F-0.830.528P-0.050.05MS-1690.9840.19324IL-6TNF-α-X+SnIL-6pgmlTNF-αngml24139.01+38.581.32+0.2612124.45+43.051.36+0.31T-0.9970.390P-0.050.0583200294IL-6TBIL-6IL-6IL-623IL-64IL-6IL-6IL-6RTBGM5IL-6IL-667IL-6LAK8IL-6Strassann9IL-6IL-6IL-6IL-6TNF-αPBMCTTNF-α10TNF-αTNFTNF-αPBMCCD44TNF-α1112COPDTNFTNFCOPDTNF-α13TNF-α14TNF-αIL-6TNF-αIL-6TNF-α1LissoniPChrapilMDe-simoneC.Thebiologicalsignifi-canceofsolubleinterleukin-2receptorsinsolidtumorsJ.EurJCancer19902633.2AriasDiazJVaraETorres-MeleroJetal.NitritenitrateandcytolinelevelsinbronchoalveolarlavagefluidoflungcencerpatientsJ.Cancer19947451546-1551.3.IL-6J.19961722.4.IL-6J.1997234386-387.5.IL-6IL-6RJ.1999195493-494.6TakizawaHOhtoshiTOhtaKetal.GrowthinhibitionofhumanlungcancercelllinesinvitroapossibleroleintumorgrowthviaanautocrinemechanismJ.CancerRes1993534175-4187.7.-6PAaJ.199719145-47.8.IL-6ⅡrIL-6LAKJ.199612298.9StrassmannGFongMKenneyJSetal.Evidencefortheinvolvementofinterleukin6inexperimentalcancercancexiaJ.JClinInvest19928951681.10.J.199594189-190.11ZemalamMSiedcarMRuggieroIetal.TheMHCclass-ⅡandCD44moleculeareinvolvedintheinductionoftumornecrosisfactorTNFgeneexpressionbyhumanmono-cytesstimulatedwithtumorcellsJ.IntJCancer1994562269.12.J.1996223171-173.13.M.2000596-597.14.-αJ.1999226314-326.93200294