进化中保守的凋亡抑制因子Baxinhibitor21

:2006203206;:2006204221:(31962);(GX9307):524023,:,E2mail:[e-mail]:(19802),,,Baxinhibitor21,:BI21;;Bax;Bcl22:Q71:A:100028578(2007)072053420301998,BaxBI21,,1994(TestisEnhancedGeneTranscript,TEGT),BI21,,caspase()caspaseBI21,1BI21bi21,71512bi212372527kDaBI2167,2,Bcl22,,BI21C2,Bax[1]BI21,2,,BI217,2,bi2123kb,87[2],:(P1)(P2)P1P2TATA,5(52UTR)E1E1P1();P2;bi21,[3]:3,BI21mRNA2.8kb1.0kb;P1P2bi21E1E1,E1E1(35bp110bp),2BI21BI21,BI21BI21,BI21BI2190%5%;BI21BI2192%3%;BI21,BI2129%35%15%20%()BI2130%15%BI21C-,BI21Bax293,BI21YccABI21YccAATPZn2+FtsH,FtsHAAAATPase(AT2Paseassociatedtoavarietyofcellularactivities),YccAFtsH,,BI21,FtsH4352007347BI21,PCDcaspaseNTPBI21,EBBcl22BI21,3BI21Bcl22BI21,BI21BH4,BI21Bcl22,BaxBak;,BI21Bax,BI21Bax,Bax[5],BI21/Bcl2XL/Bcl22Bax[3],BI21BaxBI21,Ca2+/[4,6],BaxBcl22,BI21,bi21,,Bax(THPS)bi21-|-(MEFs)bi21+|-MEFs,THPSbi21+|+MEFsCa2+[5],:BI21Bcl22BaxBak[7];THPSbi21-|-bi21+|+bi21+|-,THPS,bi21-|-bi21+|+bi21+|-,,BI21Ca2+,MPT,CytCBI21C2ROS[8]ROSCa2+,,BI21RNAibi21,,caspase23siR2NA[3];Bax,caspase,caspasez2VAD,,caspase23[9],:BI21Bcl22,caspasecaspaseBI21PCD,BI21,BI21FAS,TNF,BI21[5]4BI214.1BI21BI21,BI21,bi21p53MybWilms(WT21),BI21:BI21,Bcl22[5]BI21Bax[10]23(TRAIL)H2O2;bi21,293BI21,bi21,:bi21HT1080,bi21,bi21HT1080,bi21[1]4.2BI21bi21,,bi21,2.8kb18,183;7,211.0kb,,BI21,,53520073474.3BI21BI21,,BI21[11][12,13]410;,[13][15]bi21,bi21,,BI21,,BI215BI21,BI21,,BI21BI21BI21,,Bcl22BI21:;p53;;:caspaseFAS(CD95),BI21,:[1]YuLH,Kawai2YamadaM,NaitoM,etal.Inductionofmam2maliancelldeathbyaplantBaxinhibitor[J].FEBSLett,2002,512(123):3082312.[2],,,.Battenin[J].,2005,13(3):2872291.[3]HuckelhovenR.BAXInhibitor21,anancientcelldeathsup2pressorinanimalsandplantswithprokaryoticrelatives[J].Apoptosis,2004,9(3):2992307.[4]BolducN,OuelletM,PitreF,etal.Molecularcharacteriza2tionoftwoplantBI21homologueswhichsuppressBax2inducedapoptosisinhuman293cells[J].Planta,2003,216(3):3772386.[5]ChaeHJ,KimHR,XuC,etal.BI21regulatesanapoptosispathwaylinkedtoendoplasmicreticulumstress[J].MolCell,2004,15(3):3552366.[6]HuckelhovenR,DechertC,KogelKH.OverexpressionofbarleyBAXinhibitor1inducesbreakdownofmlo2mediatedpenetrationresistancetoBlumeriagraminis[J].ProcNatlAcadSciUSA,2003,100(9):555525560.[7]WestphalenBC,WessigJ,LeypoldtF,etal.BI21protectscellsfromoxygenglucosedeprivationbyreducingthecalciumcontentoftheendoplasmicreticulum[J].CellDeathDiffer,2005,12(3):3042306.[8]Kawai2YamadaM,OhoriY,UchimiyaH.DissectionofAra2bidopsisBaxinhibitor21suppressingBax2,hydrogenperoxide,andsalicylicacid2inducedcelldeath[J].PlantCell,2004,16(1):21232.[9]PerfettiniJL,ReedJC,IsraelN,etal.RoleofBcl22familymembersincaspase2independentapoptosisduringChlamydiainfection[J].InfectImmun,2002,70(1):55261.[10]Kawai2YamadaM,SaitoY,JinL,etal.AnovelArabidopsisgenecausesBax2likelethalityinSaccharomycescerevisiae[J].JBiolChem,2005,280(47):39468239473.[11]GrzmilM,ThelenP,HemmerleinB,etal.Baxinhibitor21isoverexpressedinprostatecanceranditsspecificdown2regula2tionbyRNAinterferenceleadstocelldeathinhumanprostatecarcinomacells[J].AmJPathol,2003,163(2):5432552.[12]delCarmenGarciaMolinaWolgienM,daSilvaID,VillanovaFE,etal.DifferentialgeneexpressionassessedbycDNAmi2croarrayanalysisinbreastcancertissueundertamoxifentreat2ment[J].EurJGynaecolOncol,2005,26(5):5012504.[13]GrzmilM,KaulfussS,ThelenP,etal.Expressionandfunc2tionalanalysisofBaxinhibitor21inhumanbreastcancercells[J].JPathol,2006,208(3):3402349.[14]SchmitsR,CochloviusB,TreitzG,etal.Analysisofthean2tibodyrepertoireofastrocytomapatientsagainstantigensex2pressedbygliomas[J].IntJcancer,2002,98(1):73277.[15]TanakaR,IshiyamaT,UchiharaT,etal.ExpressionoftheBaxinhibitor21geneinpulmonaryadenocarcinoma[J].Canc2er,2006,106(3):6482653.[:;:]6352007347