calcusyn-说明书

CalcuSynforWindowsSoftwareforDoseEffectAnalysisPublishedandDistributedby©Copyright1996-2005POBox10938,FergusonMO63135,USA2DDolphinWay,StaplefordCambridge,CB25DW,UKDISCLAIMERTheauthorandpublishermakenorepresentationorwarrantieswithrespecttotheprogramsormanualandspecificallydisclaimanyimpliedwarrantiesofmerchantabilityorfitnessforpurpose.COPYRESTRICTIONSThepurchasermaymakeasinglebackupcopyofCalcuSynforhisorherownuse.Productionofothercopiesisnotpermitted.Storageofthisprograminanyothercomputerformatorretrievalsystemortransmittalinanyformwithoutpriorpermissionofthepublisherisstrictlyforbidden.PrinedintheU.K.CalcuSyn2Contents3ContentsCONTENTS...........................................................................3INTRODUCTION...................................................................7SystemRequirements..........................................................................7InstallingCalcuSynonyourComputer..............................................7Registration...........................................................................................7TechnicalSupport................................................................................7ContactingBiosoft................................................................................8THEORYOFDOSE-EFFECTANALYSIS............................9TheMass-ActionLaw...........................................................................9WhyaPhysical-chemicalApproach:...................................................9ADerivedUnifiedTheory:...................................................................9TheMedian-EffectPrinciple..............................................................10TheMedian-effectEquationofChou................................................10TheMedian-effectPlotandParameters...........................................10TheCombinationIndexandIsobologram........................................11TheCombinationIndexEquationandPlotofChou-Talalay.............11TheIsobologramsandtheirEquations.............................................12TheDose-reductionIndexofChou...................................................12WhatisSynergism:ComplexityandPitfalls.....................................12ExperimentalDesignforDrug-combinationStudies.........................13APPLICATIONOFTHECHOU-TALALAYMETHOD........15ScopeofApplication..........................................................................15ByTypeofDrugsorModalityofTreatmentAgents..........................15ByExperimentalDesign....................................................................15ExampleofPreviouslyPublishedApplications..............................16CalcuSyn4HowmuchSynergismisSynergy?...................................................17CIandIsobolEquationsfornDrugs................................................18CALCUSYN:USINGTHEPROGRAM...............................19CreatingaNewExperiment...............................................................19UsingtheContentsPane...................................................................19EnteringaSingleDrug.......................................................................20UsingtheAddDrugWizard..............................................................20AddingaDrugManually....................................................................23EnteringaCombinationDrug............................................................27UsingtheAddDrugWizard..............................................................27AddingaCombinationManually.......................................................29EnteringaNon-Constant-RatioDrug................................................32ViewReports.......................................................................................34ReportContents................................................................................34ViewGraphs........................................................................................36ImportingRawData............................................................................37RawDataGridImport.......................................................................37Files...................................................................................................38ODBC................................................................................................39DrugImport.......................................................................................40CommandLineImport......................................................................40ExportingResults...............................................................................44RawData..........................................................................................44Reports..............................................................................................44Graphs..............................................................................................44MonteCarloSimulation..................................................