mTOR通路及其抑制剂抗肿瘤的研究进展

mTOR通路及其抑制剂抗肿瘤的研究进展作者：黄嘉佳，林桐榆，HUANGJia-Jia，LINTong-Yu作者单位：华南肿瘤学国家重点实验室,广东,广州,510060;中山大学肿瘤防治中心内科,广东,广州,510060刊名：癌症英文刊名：CHINESEJOURNALOFCANCER年，卷(期)：2007,26(12)被引用次数：9次参考文献(74条)1.SehgalSNSirolimus:itsdiscovery,biologicalproperties,andmechanismofaction[外文期刊]2003(z3)2.WiederrechtGJ;SabersCJ;BrunnGJMechanismofactionofrapamycin:newinsightsintotheregulationofG1-phaseprogressionineukaryoticcells19953.EdingerAL;ThompsonCBAktmaintainscellsizeandsurvivalbyincreasingmTOR-dependentnutrientuptake[外文期刊]2002(07)4.DannSG;SelvarajA;ThomasGmTORComplex1-S6K1signaling:atthecrossroadsofobesity,diabetesandcancer[外文期刊]2007(06)5.JacintoE;FacchinettiV;LiuDSIN1/MIP1maintainsrictor-mTORcomplexintegrityandregulatesAktphosphorylationandsubstratespecificity[外文期刊]2006(01)6.SarbassovDD;GuertinDA;AliSMPhosphorylationandregulationofAkt/PKBbytherictor-mTORcomplex[外文期刊]2005(5712)7.GuertinDA;SabatiniDMAnexpandingroleformTORincancer[外文期刊]2005(08)8.FengZ;HuW;deStanchinaETheregulationofAMPKbetal,TSC2,andPTENexpressionbyp53:stress,cellandtissuespecificity,andtheroleofthesegeneproductsinmodulatingtheIGF-1-AKT-mTORpathways[外文期刊]2007(07)9.KisfalviK;ReyO;YoungSHInsulinpotentiatesCa2+signalingandphosphatidylinositol4,5-bisphosphatehydrolysisinducedbyGq-coupledreceptoragoniststhroughanmTOR-dependentpathway[外文期刊]2007(07)10.NaveBT;OuwensM;WithersDJMammaliantargetofrapamycinisadirecttargetforproteinkinaseB:identificationofaconvergencepointforopposingeffectsofinsulinandaminoaciddeficiencyonproteintranslation[外文期刊]1999(Pt.2)11.SarbassovDD;AliSM;SenguptaSProlongedrapamycintreatmentinhibitsmTORC2assemblyandAkt/PKB[外文期刊]2006(02)12.EdingerAL;LinardicCM;ChiangGGDifferentialeffectsofrapamycinonmammaliantargetofrapamycinsignalingfunctionsinmammaliancells[外文期刊]2003(23)13.ChoeG;HorvathS;CloughesyTFAnalysisofthephosphatidylinositol3'-kinasesignalingpathwayinglioblastomapatientsinvivo[外文期刊]2003(11)14.PaezJ;SellersWRPI3K/PTEN/AKTpathway.Acriticalmediatorofoncogenicsignaling200315.DennisPB;JaeschkeA;SaitohMMammalianTOR:ahomeostaticATPsensor[外文期刊]2001(5544)16.FangY;Vilella-BachM;BachmannRPhosphatidicacid-mediatedmitogenicactivationofmTORsignaling[外文期刊]2001(5548)17.InokiK;OuyangH;LiYSignalingbytargetofrapamycinproteinsincellgrowthcontrol[外文期刊]2005(01)18.MarzecM;KasprzyckaM;LiuXOncogenictyrosinekinaseNPM/ALKinducesactivationoftherapamycin-sensitivemTORsignalingpathway[外文期刊]2007(38)19.PelletierCL;MaggiLBJr;BradySNTSC1setstherateofribosomeexportandproteinsynthesisthroughnucleophosmintranslation[外文期刊]2007(04)20.WangMY;LuKV;ZhuSMammaliantargetofrapamycininhibitionpromotesresponsetoepidermalgrowthfactorreceptorkinaseinhibitorsinPTEN-deficientandPTEN-intactglioblastomacells[外文期刊]2006(16)21.GaoX;ZhangY;ArrazolaPTsctumoutsuppressorproteinsantagonizeamino-acid-TORsignalling[外文期刊]2002(09)22.GubaM;vonBreitenbuchP;SteinbauerMRapamycininhibitsprimaryandmetastatictumorgrowthbyantiangiogenesis:involvementofvascularendothelialgrowthfactor[外文期刊]2002(02)23.PerryB;BanyardJ;McLaughlinERAKT1overexpressioninendothelialcellsleadstothedevelopmentofcutaneousvascularmalformationsinvivo[外文期刊]2007(04)24.BoosaniCS;MannamAP;CosgroveDRegulationofCOX-2mediatedsignalingby{alpha}3typeⅣnon-collagenousdomainintumorangiogenesis[外文期刊]2007(04)25.SunHL;LiuYN;HuangYTYC-1inhibitsHIF-1expressioninprostatecancercells:contributionofAkt/NF-kappaBsignalingtoHIF-1alphaaccumulationduringhypoxia[外文期刊]2007(27)26.NeshatMS;MellinghoffIK;TranCEnhancedsensitivityofPTEN-deficienttumorstoinhibitionofFRAP/mTOR[外文期刊]2001(18)27.ShiY;GeraJ;HuLEnhancedsensitivityofmultiplemyelomacellscontainingPTENmutationstoCCI-7792002(17)28.HuangS;HoughtonPJInhibitorsofmammaliantargetofrapamycinasnovelantitumoragents:frombenchtoclinic2002(02)29.VogtPKPI3-kinase,mTOR,proteinsynthesisandcancer[外文期刊]2001(11)30.ProudCGSignallingtotranslation:howsignaltransductionpathwayscontroltheproteinsyntheticmachinery[外文期刊]2007(02)31.MartinJL;BaxterRCExpressionofinsulin-likegrowthfactorbindingprotein-2byMCF-7breastcancercellsisregulatedthroughthephosphatidylinositol3-kinase/AKT/mammaliantargetofrapamycinpathway[外文期刊]2007(05)32.ChowS;MindenMD;HedleyDWConstitutivephosphorylationoftheS6ribosomalproteinviamTORandERKsignalingintheperipheralblastsofacuteleukemiapatients[外文期刊]2006(09)33.BurchertA;WangY;CaiDCompensatoryPI3-kinase/Akt/mToractivationregulatesimatinibresistancedevelopment2005(10)34.RobertsLR;GoresGJHepatocellularcarcinoma:molecularpathwaysandnewtherapeutictargets[外文期刊]2005(02)35.BessardA;FreminC;EzanFMEK/ERK-dependentuPARexpressionisrequiredformotilityviaphosphorylationofP70S6Kinhumanhepatocarcinomacells[外文期刊]2007(02)36.PapadimitrakopoulouV;AdjeiAATheAkt/mTORandmitogen-activatedproteinkinasepathwaysinlungcancertherapy2006(07)37.ChanSM;WengAP;TibshiraniRNotchsignalspositivelyregulateactivityofthemTORpathwayinTcellacutelymphoblasticleukemia[外文期刊]2007(01)38.PantuckAJ;SeligsonDB;KlatteTPrognosticrelevanceofthemTORpathwayinrenalcellcarcinoma:implicationsformolecularpatientselectionfortargetedtherapy[外文期刊]2007(11)39.马湘一;王世宣;刘琰雷帕霉素联合紫杉醇诱导卵巢癌细胞A2780和SKOV3凋亡及其分子机制[期刊论文