海洋放线菌-药物开发的新兴资源-蔡超靖

.22.050015R978.1A1001-8751(2012)01-0022-08MarineActinomycetesanEmergingResourcefortheDrugDiscoveryCaiChao-JingDingYan-BoShanYue-QiMuYun-LongNewDrugResearch&DevelopmentCenterofNorthChinaPharmaceuticalGroupCorporation,NationalMicrobialMedicineEngineering&ResearchCenter,HebeiIndustrialMicrobialMetabolicEngineeringResearchCenter,Shijiazhuang050015Abstract:Asanimportantresourceofthenewdrugs,moreandmoreattentionswerepaidonmarineactinomycetesrecently.Thisreviewhighlightsachievementsintheisolationofmarineactinomycetes,someexamplesofbioactivemetabolitesidentifiedbytraditionalscreening,andpresentsnewprogressinthefieldofgenomeminingleadingtothediscoveryofnovelcompoundsandheterologousexpressionofbiosyntheticgeneclusters.Keywordsmarineactinomycetesbioactivesecondarymetabolitesgenomicsheterologousexpression2011-11-152050B[1][2]11969[3]FenicaJensen[4]Salinispora(MAR1)Marinispora(MAR2)13WorldNotesonAntibiotics,2012,Vol.33,No1.23.MAR1Goodfellow[5]200320105012DemequinaMarisediminicolaSalinibacteriumEuzebyaMiniimonasSalinisporaIamiaOrnithinibacterSciscionellaMarinactinosporaPhycicolaSerinicoccus[6][7][8]-HVA(NaCl)SalinisporaMarinospora[9][10][11][12]Bredholdt[13]450m112[4-5,14-15]Mayer[15][16]12.1SalinosporamideA(marizomib1)Salinisporaarenicola[17]20SSalinosporamideANereusIDiazepinomicin1RAS/MAP[18]ThallionDiazepinomicinStaurosporine(1)StreptomycesroseoflavusC[19]2.2AbyssomicinC2VerrucosisporamarisPABAPABA-MRSAabyssomicin[20]SaliniketalASaliniketalB2[21]2.320121331.24.1Table1SomenaturalproductswithbiologicalactivityisolatedfrommarineactinomycetesAmmosamidesStreptomycessp.AntiprotealideSalinisporatropica2-Allyloxyphenol,Streptomycessp.AlbidopyroneStreptomycessp.ArenamidesSalinisporaarenicolaAureoverticillactamStreptomycesaureoverticillatusAyamycinNocardiasp.Carboxamycin,Streptomycessp.CyclomarinesStreptomycessp.,SalinisporaarenicolaDaryamideCStreptomycessp.Dermacozines,Dermacoccussp.EnterocinStreptomycesmaritimusEssramycinStreptomycessp.γ-IndomycinoneStreptomycessp.IndoxamycinsStreptomycessp.LipoxazolidinonesMarinisporasp.LodopyridoneSaccharomonosporasp.LynamicinsMarinisporasp.MansouramycinsStreptomycessp.MarinisporolidesMarinisporasp.Marinopyrroles,Streptomycessp.NaseseazinesStreptomycessp.ProximicinsVerrucosisporasp.Resistoflavine,Streptomycessp.SalinamidesStreptomycessp.SalinipyroneASalinisporapacificaSalinisporamycinSalinisporaarenicolaSplenocinsStreptomycessp.StreptokordinStreptomycessp.TartrolonDStreptomycessp.TirandamycinsStreptomycessp.ViolaceinPseudomonassp.WorldNotesonAntibiotics,2012,Vol.33,No1.25.Thiocoraline3[22]DNAThiocoralinePharmaMarLucentamycinsA-D3NocardiopsislucentensisLucentamycinsABCDLucentamycinsAB,[23]Piperazimycins[24]2.4MarinomycinsA-DMarinisporasp.,MarinomycinsA4MRSAMarinomycinB-C4[25]SporolideASiporoldeB4Salinisporatropica11,SporolideA[26]ChalcomycinCChalcomycinD4[27]StreptomycesgriseusAplasmomycinsA-C432[28-29]Maduralide3Actinomycetales24[30](1)3SalinisporatropicaUdwary[31]Sal.tropica5.18Mbp17Penn[32]200919Salinisporaarenicola1Figure1Alkaloidcompoundsfrommarineactinomycetes2Figure2Polyketidecompoundsfrommarineactinomycetes20121331.26.Sal.tropicaSal.arenicolaSal.arenicola3012Sal.Tropica18Sal.arenicolastaurosporinecyclomarineSal.tropicasalinosporamidesporolidesalinilactam16SrRNA99%16SrRNA3Figure3Peptidecompoundsfrommarineactinomycetes1987Hopwood[33]S.coelicolorS.parvulusS.avermitilis[34]WorldNotesonAntibiotics,2012,Vol.33,No1.27.4Figure4Macrolidecompoundsfrommarineactinomycetes20121331.28.[35]Micromonosporasp.ACM2-092Micromonosporasp.ML1ThiocoralineS.albusS.lividanThiocoraline[36]Streptomycessp.CNQ-525napyradiomycinS.albusnapyradiomycins[37],4,PodarM,ReysenbachAL.Newopportunitiesrevealedby[1]biotechnologicalexplorationsofextremophiles[J].CurrentOpinioninBiotechnology,2006,17(3):250[J].2010,29(5):57WeylandH.ActinomycetesinNorthSeaandAtlanticOcean[3]sediments[J].Nature,1969,223(5208):858FenicalW,JensenPR.Developinganewresourcefor[4]drugdiscovery:marineactinomycetebacteria[J].NatureChemicalBiology,2006,2(12):666GoodfellowM,FiedlerHP.Aguidetosuccessful[5]bioprospecting:informedbyactinobacterialsystematics[J].AntonieVanLeeuwenhoek,2010,98(2):119.Progressinthebio-diversitystudiesofculturablemarineactinobacteria[J].,2007,34(5):996BrunsA,CypionkaH,OvermannJ.CyclicAMPandacyl[7]homoserinelactonesincreasethecultivationefficiencyofheterotrophicbacteriafromthecentralBalticSea[J].AppliedandEnvironmentMicrobiology,2002,68(8):3978MincerTJ,JensenPR,KauffmanCA,etal.Widespreadand[8]persistentpopulationsofamajornewmarineactinomycettaxoninoceansediments[J].AppliedandEnvironmentMicrobiology,2002,68(10):5005GontangEA,FenicalW,JensenPR.Phylogeneticdiversity[9]ofgram-positivebacteriaculturedfrommarinesediments[J].AppliedandEnvironmentMicrobiology,2007,73(10):3272BouvierT,delGiorgioPA.Keyroleofselectiveviral-[10]inducedmortalityindeterminingmarinebacterialcommunitycomposition[J].EnvironmentalMicrobiology,2007,9(2):287ZenglerK,ToledoG,RappeM,etal.Cultivatingthe[11]uncultured[J].ProceedingsoftheNationalAcademyofSciences,2002,99(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