中发生物工程有限公司市场提升营销方案

中发生物工程有限公司市场提升营销方案作者：李春波学位授予单位：上海海事大学相似文献(10条)1.外文期刊Rishton.GMNaturalproductsasarobustsourceofnewdrugsanddrugleads:pastsuccessesandpresentdayissues.Thehistoryofdrugdevelopmenthasitsfoundationfirmlysetinthestudyofnaturalremediesusedtotreathumandiseaseovercenturies.Analysisofmedicinalplants,bioactivecultures,andincreasedunderstandingofmicronutrientsinthefoodchainopenedthedoortothedevelopmentofpurifiedanddefinedchemicalcompoundsasdose-controlledmedicines.Thus,withtheearlydiscoveryofcardiotonicsinfoxglove,salicylicacidinwillowbark,morphineinpoppies,andpenicillininmold,thepharmaceuticalindustrywaslaunched.Suchnaturalsmallmoleculesservedastreatmentsfordiseaseandultimately,aspharmacologictoolstoenabletheunderstandingofthebiochemicalpathwaysandmechanismsofdisease.Incontrast,moderndrugdiscoverytechnologiescoupledwiththepowerfultoolsofbiotechnologyhaveprompteddrugdiscoveryorganizationstofocusontarget-drivendrugdiscoveryatthemolecularlevelbylaunchinghigh-throughputscreeningprogramsusingartificialbiochemicalassays.Atatimewhenthepharmaceuticalindustryhascomeunderscrutinyforhighratesofdrugdevelopmentfailure,itisinterestingtoseethatnaturalproductsdrugdiscoveryhasbeenmarginalizedinfavorofthishigh-throughputbiochemicalscreeningparadigm.Ifmoderndrugdevelopmentisonceagaintobenefitfromnaturalproductsasasource,thenthelimitationsofartificialbiochemicalassaysasappliedtothescreeningofnaturalextractsmustberealizedinordertocapitalizeonthevastnaturalmoleculardiversityandrichethnobotanicdatathathasemergedworldwide.Naturalcompoundscanagainbecomecentralplayersinthetreatmentofdiseaseandintheunderstandingofdiseasemechanisms.2.外文期刊SimekSLCharacterizationofgenetherapyproductsandtheimpactofmanufacturingchangesonproductcomparability.Genetherapyproductsrepresentanovelandcomplexclassofproducts.Ensuringproductsafety,identity,purityandpotencyfollowingamanufacturingchangeextendsnotonlytoassessingthefinalformulatedproductbutalsoallthecomponentsusedduringproductmanufacturing.CBERhasimplementedastepwiseapproachtoproductcharacterizationandcompliancewithcGMPs,whichincreasesasthestudymovesfromphase1towardphase3andlicensing.Itisimportantthatproductcharacterizationbeperformedearlyinproductdevelopmentbecausewithoutfullproductcharacterizationitwillbedifficulttodeterminetheimpactofthemanufacturingprocessontheproductaswellastheimpactanymanufacturingchangewillhaveontheproduct.Todemonstrateproductcomparabilityathoroughunderstandingofthemanufacturingprocess,includingproductcharacterization,isnecessary,sothattheimpactofamanufacturingchangecanbeaccuratelyassessed.3.外文期刊Rengasamy.RAperspectiveonthebiotechnologicalpotentialofmicroalgae.Microalgaearetheuntappedresourcewithmorethan25,000speciesofwhichonly15areinuse.Inrecentyears,microalgalculturetechnologyisabusinessorientedlineowingtotheirdifferentpracticalapplications.Innovativeprocessesandproductshavebeenintroducedinmicroalgalbiotechnologytoproducevitamins,proteins,cosmetics,andhealthfoods.Formostoftheseapplications,themarketisstilldevelopingandthebiotechnologicaluseofmicroalgaewillextendintonewareas.Withthedevelopmentofsophisticatedcultureandscreeningtechniques,microalgalbiotechnologycanmeetthechallengingdemandsofboththefoodandpharmaceuticalindustries.Geneticimprovementshouldalsoplayanimportantroleinthefuturedevelopmentofalgalindustries.Basedonthepreliminaryresearch,severaltherapeuticbenefitshavebeenclaimedforcommerciallyproducedmicroalgaeincludingAIDS,cancer,andCerebrovasculardiseases.Innearfuture,algalbiomasswillserveasarenewableenergysourcethroughcommercialproductionofhydrocarbonbyBotryococcusthroughouttheworld.4.外文期刊PelaezFThehistoricaldeliveryofantibioticsfrommicrobialnaturalproducts--canhistoryrepeat?Microbialnaturalproductsaretheoriginofmostoftheantibioticsonthemarkettoday.However,researchinantibioticsandnaturalproductshasdeclinedsignificantlyduringthelastdecadeasaconsequenceofdiversefactors,amongwhichthelackofinterestofindustryinthefieldandthestrongcompetitionfromcollectionsofsyntheticcompoundsassourceofdrugleads.Asaconsequence,thereisanalarmingscarcityofnewantibioticclassesinthepipelinesofthepharmaceuticalindustry.Still,microbialnaturalproductsremainthemostpromisingsourceofnovelantibiotics,althoughnewapproachesarerequiredtoimprovetheefficiencyofthediscoveryprocess.Theimpactofmicrobialbiodiversity,theinfluenceofgrowthconditionsontheproductionofsecondarymetabolites,thechoiceofthebestapproachatthescreeningstepandthechallengesfacedduringtheisolationandidentificationoftheactivecompoundsareexaminedinthisreviewasthecriticalfactorscontributingtosuccessintheeffortofantibioticdiscoveryfrommicrobialnaturalproducts.5.外文期刊BussADNaturalproducts--thefuturescaffoldsfornovelantibiotics?Naturalproductshaveplayedapivotalroleinantibioticdrugdiscoverywithmostantibacterialdrugsbeingderivedfromanaturalproductornaturalproductlead.However,therapidonsetofresistancetomostantibacterialdrugsdiminishestheireffectivenessconsiderablyandnecessitatesaconstantsupplyofnewantibioticsforeffectivetreatmentofinfections.Thenaturalproducttemplate