喷雾干燥粘壁的原因与解决途径---

36620076AppliedChemicalIndustryVol.36No.6Jun.2007:2007204226:(Q200611007);(2006XZ4):(1966-),,,,,:027-63435189,E-mail:[e-mail],(,430081)::;;:TQ028.6:A:1671-3206(2007)06-0599-04ReasonsforwallstickingduringspraydryingandcountermeasuresZHOUXue2yong,GAOJian2bao(CollegeofChemicalEngineeringandTechnology,WuhanUniversityofScienceandTechnology,Wuhan430081,China)Abstract:Thetypesandreasonsforwallstickingduringspraydryingwereanalysed.Therearethreetypesofwallsticking:halfwetmaterials,materialswithlowmeltingpoint,drypowder.Thewallstickingofhalfwetmaterialisconcernedtothestructure,fixingandoperationofspraydryingtowerandsprayer,themo2tionofhotairintower.Themeltingstickingoccurredwhenthemeltingpointofmaterialsislowerthanthedryingtemperature.Thewallstickingofdrypowderisconcernedtogeometricfigureofcyclonechamber,roughnessofwall,velocityofairandstaticcharge.Themethodsforresolvingthewallstickingwereputforward.Keywords:spraydrying;fogdrop;wallsticking,(),,,,,,,,,,,,,13[1]:1.1,,,,36,1.2,,,1.3,,,[2],,,22.12.1.1,,,,,,,,,[3],,90,,[4],100,,100200,,2.1.2,,,,,,,,,[5],,10mm,,,,,,10,,[627],,,2.1.3,,,,,,,,,,2.1.4,,,,,,,,,,,,,,,,[8],,,,,,0066:,tm,;,[9],d[10]:=1.0410-4d1.87(1)(1),,,,,,,[11]dptg2=(2)d,m;p,Pa;,rad,,,[12],,[13]u0=BpL(3)u0,m/s;B;p,Pa;L,kg/m3,,,2.1.5[14],,180m3/h120m3/h,1.5,,,,,,,,,,,,,,,,,,[15],,,();,,,,[13]2.2,,2.2.1,,[1]2.2.2,,2.2.3,,,[16][17]4,4,57106,2.2.4,,,,,80,,,,95,,,,,10636,[18]2.3,,2.3.1,,,,2.3.230[19],,,2.3.3[2],,,[20]3,3:3,,,,,,,:[1],,.[M].:,2003:60272.[2]MurtomaaaM,SavolainenbM,ChristiansenbL,etal.Stat2icelectrificationofpowdersduringspraydrying[J].Jour2nalofElectrostatics,2004,62:63272.[3].[J].,1994,16(5):57.[4].[J].,2000(2):43245.[5],,,.[J].,1999,26(5):2752277.[6]RicherC,HirokazuO,KazumiD.Particledesignusinga42fluid2nozzlespray2dryingtechniqueforsustainedreleaseofacetaminophenl[J].ChemPharmBull,2006,54(7):9482953.[7]KobayashiM.Newdryingtechnology:Lowtemperaturespraydrying[J].PDAJournalofGMPandValidationinJapan,2001,3(1):20227.[8]MichaelM,MurphybK,KumarbS,etal.Effectsofprocessvariablesonthepowderyieldofspray2driedtrehaloseonalaboratoryspray2dryer[J].EuropeanJournalofPharma2ceuticsandBiopharmaceutics,2005,59:5652573.[9]AlyssonLRR,WanderleyPO.Spraydryingconditionsandencapsulatingcompositioneffectsonformationandpropertiesofsodiumdiclofenacmicroparticles[J].PowderTechnology,2006,171:7214.[10].[J].,1980(4):57261.[11]MohamedNEA.Anatomizationtheoryforswirlnozzles[J].TransactionsofASAE,1978,21(1):70274.[12]KincaidDC.Sprinklerpatternradius[J].TransactionsofASAE,1982,25(6):166821672.[13]HuangLX,KumarK,MujumdarcAS.Acomparativestudyofaspraydryerwithrotarydiscatomizerandpres2surenozzleusingcomputationalfluiddynamicsimulations[J].ChemicalEngineeringandProcessing,2006,45:4612470.[14],.[J].,1989,18(5):35237.[15]GoulaAM,AdamopoulosKG.Spraydryingoftomatopulpindehumidifiedair:I.Theeffectonproductrecovery[J].JournalofFoodEngineering,2005,66:25234.[16]YoshiiH,OhhashiT,FurutaT,etal.Enzymeencapsula2tionwithcrystaltransformationofanhydrousmaltoseoranhydroustrehalose[J].JournalofAppliedGlycoscience,2006,53(2):992103.[17],,,.[J].,2006,28(1):18220.[18],.[J].,2006,27(3):10213.[19]DinaNM,MadhuB,ShailendraK,etal.Spraydriedex2cipientbase:Anoveltechniquefortheformulationoforal2lydisintegratingtablets[J]ChemPharmBull,2006,54(1):992102.[20],,,.[J].:,2003,41(6):7062707.206