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21Vol.2No.120121AgriculturalEngineeringJan.20122011-12-102012-01-12、。E-mailyangjing621@126.com310058。。R151A2095-1795201201-0054-06PhysiologicalFunctionandApplicationofL-CarnitineinFunctionalFoodYangJingBiologicalSystemsEngineering&FoodScienceCollegeZhejiangUniversistyHangzhou310029ChinaAbstractL-carnitineisanaturalsubstanceforhuman’sbodywhichcanspeedupthemetabolismsintransferringfattyacidsintoenergyandthiswaysupportsloseweightandrelativefunctions.InthispaperchemicalstructuresphysiologicalfunctionsandapplicationofL-carnitineinfunctionalfoodweresummarized.KeywordsL-carnitineChemicalStructurePhysiologicalfunctionsApplicationinfunctionalfood0L-carnitine、BT。。。50mg500mg。。、。、、。1-56-10。、、。11.1L、DDLLDLL。LDD。3--a--3R---3--4-β--γ-93R---3-hy-droxy-4-trimethylammoniobutanoateC7H15O3N162.2210~212℃αD20=-29.5~32.00200℃0.1H2O111。1Fig.1StrucuresofL-carnitinepHpH3~61200℃。、12。1.2、、。2①。、。20g。。2100mgkg。、。②。L-、、C、、B6、、513。13-14。、S-ε-4152。2Fig.2BiosynthesisofL-carnitineinvivo216-18。2.1CoACoA19CoACoA。CoACoA20-21。ACoACoACoAⅠⅡCoA223。3Fig.3L-Carnitinecarryfatacylintomitochondria2.2β-。23-24。β-25。1626。2.3。。27。。552.423。。、28。2.5、。29、。。2.619。2030。、19。26。。、31。3、。、。。、、、32-37。。3.1、“”。5%~25%38。。39。β-。4041。、、、14。3.2、42。15%。。43。。70~90mgkgGB14880-199422。3.365。。、—。。44。3.4FDAADI20mgkg·d-11200mg13。。。。50mg20mg。5mg。3.5β-。20%。。L-7.5~10g、、。、。45。3.6metabolicsyndromeMSII46-47。。。48249+、、50。3.7。。511073。。28。4、。、。。。1.-J.200621618-23.75HuMenghongWangYouji.TheprospectofL-carnitineasaaddi-tiveinfishdietsJ.ModernFisheriesInformation200621618-23.2.L-J.20061227-31.3.L-J.2006271056-58.LiHaijunShaoQingjunNieYuemei.ApplicationofL-carnitineinmarinelivesJ.FeedIndustry2006271056-58.4.L-J.200535519-21.5.、L-J.2005417-19.6.J.20052691225-1226.7.J.200711654-655.8.CJ.20052111640.9.J.200518S156.10.-J.2005276433-435.WangLuWangKepingYuChangqingetal.L-carnitineeffectsonanemiainuremicpatientstreatedwitherythropoietinJ.JournalofDalianMedicalUniversity2005276433-435.11.L-J.2006313136-139.WangYuanyangZhaoYanhua.CurrentsituationaboutthestudyofL-carnitineanditsapplicationJ.FoodScienceandTechnolo-gy2006313136-139.12.J.2005384-85.13.J.20051037-39.14GoudriaanJRDenBoerMARensenPCetal.CD36defi-ciencyinmiceimpairslipoproteinlipase-mediatedtriglycerideclear-anceJ.JLipidRes2005462175-2181.15.J.201117152356-23572360.FanJingjingLvChaoTengWenjiaoetal.DevelopmentofthestudiesonrelationshipsbetweenL-carnitineandmetabolicsyndromeJ.MedicalRecapitulate201117152356-23572360.16BremerJ.CarnitinemetabolismandfunctionsJ.PhysiolRev1983631420-1480.17KanekoTYoshidaR.OntheabsoluteconfigurationofL-carnitineJ.BullChemSocJpn1962351153-1155.18.D.2006.JiangHeng.ProtectiveeffectsofL-carnitineonthecisplatin-in-ducedkidneydamageinratsD.ChongqingThirdMilitaryMedicalUniversity2006.19JiHBradleyTM.AtalanticsalmonsalmonsalarfedL-carnitineexhibitalteredintermdiarymetabolismandreducedtissuelipidbutnochangeingrowthrateJ.JournalofNutrition199612681937-1950.20JeltjeRGoudriaanMarionAMdenBoerPatrickCNRensenetal.CD36deficiencyinmiceimpairslipoproteinlipase-mediatedtriglycerideclearanceJ.TheJournalofLipidResearch2005462175-2181.21.L-J.2005941-43.LiuXiaogengWangSiqing.ProgressinstudiesandapplicationofL-carnitineJ.JournalofCereals&Oils2005941-43.22.J.2005137556-558.23BrassEPBeyerinckRA.Effectsofpropionateandcarnitineonthehepaticoxidationofshort-andmedium-chainlengthfattyacidsJ.BiochemJ1988250819-825.24ColquhounA.Inductionofapoptosisbypolyunsaturatedfattyacidsanditsrelationshiptofattyacidinhibitionofcarnitinepalmitoyltrans-feraseIactivityinHep2cellsJ.BiochemMolBiolInt199845331-333.25HelmsR.EnhancedlipidutilizationininfantsreceivingoralL-cam-itineduringlong-termparenternutritionJ.JPediat1986109984.26.、J.200635427-2836.MaLiMaJianfeiDingHongetal.EffectsofL-carnitineonproliferationapoptosisandfibronectinsecretionofhumanperito-nealmesothelialcellsunderhighglucoseconditionJ.JournalofChinaMedicalUniversity200635427-2836.27.J.2011117740-742.ZhouXiaoyanChenJingLiuChangxiuetal.Empiricalstudyonanti-fatigueeffectofL-CarnitineJ.JournalofTropicalMedi-cine2011117740-742.28.J.2005219994-995.29KanterMMWilliamsMH.AntioxidantscarnitineandcholinesasputativeergogenicaidsJ.IntJNutr199556120-131.30.J.20051110761-764.LiZhengChenGuowuShangXuejunetal.Acontrolledran-domizedtrialoftheuseofcombinedL-carnitineandacetyl-L-carni-tinetreatmentinmenwitholigoasthenozoospermiaJ.NationalJournalofAndrology20051110761-764.31.L-J.2006625-27.32.L-J.201026283-96.ZhangBaohua.TheinfluenceofL-carnitineonthebodyshapeofwomenJ.JournalofShanxiDatongUniversityNaturalScienceEdition201026283-96.33.85J.20071316-8.HuangZongxiuLinJianLinChunfang.AssessmentofL-carni-tine'sweightcontrolfunctioninobesepopulationJ.PreventiveMedicineTribune20071316-8.34.-J.20042624-26.35.、L-J.20109129-31.FanXueYanZheng.TheeffectoforganicchromiumL-carnitineandaerobicsexerciseonthelipidmetabolismofratswithhighfatdi-etJ.JournalofNanjingInstituteofPhysicalEducationNaturalScience20109129-31.36.2J.2000213215-218.LiYanbingLiangYiquanQinWanwenetal.L-carnitineino-verweighttypy2diabetesmellitusJ.JournalofSunYat-SenUn
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