菊粉和低聚果糖可增加钙的吸收利用-孙晓红

··孙晓红　VonkRJ　孙建琴(审校)　　。。、。,。。,。,。,[1,2]。。400～5001011～1012·g-1。。。,,,。。,、,、[3]。、。,。,(、),,,。:550004　();(VonkRJ);()1.(1):,、、、。,2～60。,,2～10。。β-。2～4[4]。。、、。β(2,1)。。。(、、),。,90%～95%,[5]。(2):。(、、)(、)。,,。,、pH。(95%),。,。。,(20%～25%),[6]。,83　2003291　ChinJOsteoporos,Feb.2003Vol9,No.1。,[7]。(3):。Gibson[8,9]E.Coli。,。,108.8·g-1109.5·g-1109.2·g-11010.1·g-1,、,[10]。BuddingtonKleessen[11]。2.、、,。5%～20%[12-15]。Morohashi[16]45Ca、。。。93×340g40g,28d,、、、。[(21.3±12.25)%(33.7±12.1)%][17]。VandenHeuvel[18]1214～1615g,(47.8±16.4)%()(60.1±17.2)%()。。Ohta[19,20]。,Takahara[21]X,。。Scholz-Ahrens[22],5g·kg-110g·kg-1。,(P0.01)。。[23]。3.,。:①pH,。Demigne[24]15%,15%3g·kg-1,pH7.05.3,(18±3)μmol(122±10)μmol;8g·kg-1,pH7.15.9,(28±4)μmol(132±12)μmol;②,,H+,H+Ca2+,H+[25]。Trinidad650mmolCaCl2·L-1,,。[26];③[27]。④Ohta[28,29]。1,25D。。。。。。。。。1　RoberfroidMB.Prebioticsandprobiotics:aretheyfunctionalfoods?AmJClinNutr,2000,71(Suppl):1682S-1687S.2　CollinsMD,GibsonGR.Probiotics,prebiotics,andsynbiotics:approaches84　2003291　ChinJOsteoporos,Feb.2003Vol9,No.1formodulatingthemicrobialecologyofthegut.AmJClinNutr,1999,69(Suppl):1052s-1057s.3　SalminenS.Functionalfoodscienceandgastrointestinalphysiologyandfunction.BrJnutr,1998,80(Suppl):S147-S171.4　NinessKR.Inulinandoligofructose:whatarethey?JNutr,1999,129:1402s-1406s.5　DelzenneNM,RoberfroidMR.Physiologicaleffectsofnondigestibleoligo-sacccharides.Lebensm.WissTechnol,1994,27:1-6.6　SchummannWC.Metabolismof(2-14C)acetateanditsuseinassessingheptickrebscycleactivityandgluconeogenesis.JBioChem,1991,266:6985-6990.7　RoedigerWEW.Thecolonicepitheliuminulcerativecolitis:anenergy-de-ficiencydisease?Lancet,1980,2:712-715.8　WangX,GibsonGR.Effectsoftheinvitrofermentationofoligofructoseandinulinbybacteriagrowinginthehumanlargeintestine.JApplBacte-riol,1993,75:373-380.9　RoberfroidMB.Thebifidogenicnatureofchicoryinulinanditshydrolysisproducts.JNutr,1998,128:11-19.10　GibsonGR.Selectivestimulationofbifidobacteriainthehumancolnbyoligofructoseandinulin.Gastroenterology,1995,108:975.11　KleesenB.Effectofinulinoncolonicbifidobacteriaofelderlyman.FASEBJ,1994,8:A185.12　RemesyC,Cecalfermentationinratsfedoligosaccharides(inulin)aremodulatedbydietarycalciumlevel.AmJPhysiol,1993,264:G855-G862.13　DelzenneN.Effectoffermentablefructo-oligosaccharidesonmineral,ni-trogenandenergydigestivebalanceintherats.LifeScience,1995,57:1579-1587.14　OhtaA.Effectsoffructooligosaccharidesontheabsorptionofmagnesiumandcalciumbycecectomizedrats.IntJVitamNutrRes,1994,64:316-323.15　OhtaA.EffectoffructooligosaccharidesandothersaccharidesonCa,MgandPabsorptioninrats.JJpnSocNutrFoodSci,1993:46:123-129.16　MorohashiT.Truecalciumabsorptionintheintestineisenhancedbyfructooligosaccharidefeedinginrats.JNutr,1998,128(10):1815-1818.17　CoudrayC.Effectofsolubleorpartlysolubledietaryfibressupplementa-tiononabsorptionandbalanceofcalcium,magnesium,ironandzincinhealthyyoungMen.EurJClinNutr,1997,51:375-380.18　VanDenHeuvelEGHM.Oligofructosestimulatescalciumabsorptioninadolescents.AmJClinNutr,1999:69(3):544-548.19　OhtaA.Dietaryfructooligosaccharidespreventosteopeniaaftergastrecto-myinrats.JNutr,1998,128:106-110.20　OhtaA.Dietaryfructooligosaccharidespreventpostgastrectomyanemiaandosteopeniainrats.JNutr,1998,128:485-490.21　TakaharaS.Fructooligosaccharideconsumptionenhancesfemoralronevolumeandmineralconcentrationinrats.JNutr,2000,130:1792-1795.22　Scholz-AhrensKE,VanLooJ,SchrezenmeirJ,etal.Effectofoligofruc-toseonbonemineralizationinovariectomizedratsisaffectedbydietarycalcium.AmJClinNutr,2001,73:498s.23　Scholz-AhrensKE,VanLooJ,SchrezenmeirJ.Longtermeffectofoligofructoseonbonetrabecularstructureinovariectomiezedrats.AmJClinNutr,2001,73:498s.24　DemigneC,LevratMA,YounesH,etal.Interactionsbetweenlargein-testinefermentationanddietarycalcium.EurJClinNutr,1995,49(Suppl3):235-238.25　TrinidadTP.Effectofacetateandpropionateoncalciumabsorptionintherectumanddistalcolonofhumans.AmJClinNutr,1996,63:574-578.26　GregeJL.Nondigestiblecarbohydrateandmineralbioavailability.JNutr,1999,129(7Suppl):1434s-1435s.27　CampbellJM.Selectedindigestibleoligosaccharidesaffectlargebowelmass,cecalandfecalshort-chainfattyacids,pHandmicroflorainrats.JNutr,1997,127:130-136.28　OhtaA.Dietaryfructooligosacchriadesincreasecalciumabsorptionandlevelsofmucosalcalbindin-D9kinthelargeintestineofgastrectomizedrats.ScandJGastroenterol,1998,33:1062-1068.29　TakasakiM,InabaH,OhtaA,etal.Dietaryshort-chainfruc-tooligosaccharidesincreasecalbindin-D9klevelsonlyinthelargeintes-tineinratsindependentofdietarycalciumdeficiencyorserum1,25Di-hydroxyVitaminDLevels.LntJVitamNutrRes,2000,70:206-213.(:2002-09-12)(8)　,2000,11:92-95.5　,.().,1998,4:90-92.6　CarmelietG,VicoL,BouillonR.Spaceflight:achallengefornormalbonehomeostasis.CritRevEukaryotGeneExpr,2001,11(1-3):131-144.7　,,..:,2000.241,272-274.8　GarberMA,McDowellDL,HuttonWC.Bonelossduringsimulatedweightlessness:abiomechanicalandmineralizationstudyintheratmod-el.AviatSpaceEnvironMed,2000,71:586-589.9　OsakoT,OhiraY,ItoG,IwashitaY,etal.Structureandmineralcontentinweight-bearingbonesfollowinghindlimbsuspensioninyoungrats.JpnJPhys