禽流感病毒致病性的分子生物学基础及研究近况

,(,350001):S858.3:C:1004-7034(2002)02-0041-03:;;;;:A,,8RNA8RNAHANANPM1M2PB1PB2PANS1NS210,HARNA(AviamInfluenzaVirus,AIV)A,1878100(NP)(MS),ABC,,,:,,,75%(HP),(MP)(),,,,75%,(),11.1,,80120nm,100nm,,,1.20.8%1.1%RNA70%6%20%24%,RNA,1012nm,,(HA)(NA)RNA6Mu,8RNA:2001-11-21:(1969-),,,,;(1962-),,,,.1.3,,;5630min;6010min;6570,4048h,,,1.4HANA,,HA16,H1H16;NA10,N1N10,HANA160,81,HANA28RNA123,,2RNA2,,2,10:(M1M2)(PB1PB2PA)(NS1NS2)RNA:(1)513,GGAACAAAGAUGAppp5(2)312,3HOUCGUUU2UCGUCC,34U,C(3)51521,PolyU,mRNAPolyA,HA4,HA;NA6;78,(ORF)3,,HA,,4,()HA,16HA14-HeilongjiangJournalofAnimalScienceandVeterinaryMedicine©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.1RNAKu12341PB275996NA;PB1PA22341PB175787:,,mRNA41778HA56675,;,T(CTL)51565NP49860RNA,RNA,,:CTL61413NA45475:,71027M1M2252962615,,CTL8890NS1NS22301212512,,,,13588,HA1HA2,,HA,,,HA,HANA,,,(,)4NA:NA,N-,,,NAHA,NP,,RNA(RNP),RNANP,ABCRNAPB1PB2PA,,M1M2M1,,,M2,,HApH,4,,HAHA1HA2HA1,()HA2,,N4.1HAHA,414nmHA,HA1HA2,N328HA1,C221HA2,50KD25KD,HA114HA2133HA1HA2HA1HA2HA7,6HA1,82238165285;1HA2,1544.2HAHAHA1HA2,HAHAA/Turkcy/Ireland/83-Arg-Lys-Arg-Lys-Arg-Gly-,H5H744,CEFMDCK,,HA(Arg),,,HA,HA12320,20HA1/HA2,1983H5N2,,,HA,,HANA,1989PhilpottA/Turkey/Onfario/7332/66(H5N9)HA54,,,5:(1):,(2):,(3)RNA:(4)HA,NA8,22,,256,,24HeilongjiangJournalofAnimalScienceandVeterinaryMedicine20022©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.,,H5H7,,A/Turkey/Oregon/71(H7N3),28SrRNA54HA19921993GWWoodVeyH5H7,-R-X-K/R-R-(X)4-R-X-K/R-R-A/Turkey/England/50-92/91(H5N1)-R-K-T-R-,H5,2ACAAGA,;H53GAAAAA,,,,,H7N2,,,:[1].[M].:,1995.13-80.[2],.[J].,2000,2(4):4-7.[3]DavidE,Swayne.Avianinfluenza:thevirusandthedisease[J].WorldPoultry,2000,Special:4-6.[4],.[J].,1998,20:28-30.[5],,.[J].-,1997,17(1):3-7.(003)1,1,2(1.,271018;2.,252000):S858.31:C:1004-7034(2002)02-0043-03(IB)(IBV),IBV,IBVIB,IBV,IBV1IBVRNA,cDNAIBV276005-,3-,mRNA,cDNAIBV10(ORF),6.7Ku-440Ku,5-F1-F2-S-3a-3b3c-M-5a-5b-N-Poly(A)-35-,6070nt,IBVIBV,5-5-,[l],,CTT/GAACAA,mR2NA,mRNA2-6Suton[2],RNA5-mRNA,UAAAC:2001-11-21:(1978-),,,;(1962-),,,,;(1975-),,,,.2IBVRNA[3],RNARNA,6RNA,mRNA1-mRNA6,6mRNA3-Poly(A),5-,,,RNA,RNA,RNA-,RNA,,,RNA,mRNAmRNA,mRNA,mRNARNA,mRNARNA,,,3IBV:S(S)M(M)(N)[4],3.1SIBVS,IBVSSN1034-HeilongjiangJournalofAnimalScienceandVeterinaryMedicine©1995-2004TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.