羟基磷灰石生物材料的研究现状_制备及发展前景

©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(1712081)(2325035)(3250061),,,ThePresentandProspectofResearchonHydroxyapatiteBioceramicMaterialsYuFangli1,ZhouYongqiang2,ZhangWeike3,MaJingyun1(1ShaanxiUniversityofScienceandTechnology,Xianyang,712081)(2Wen2zhouUniversityMainLaborotary,325035)(3CollegeofmaterialScience&Engineering,ShandongUniversity,Jinan,250061)Abstract:Hydroxyapatitehasexcellentbiocompatibilityandtissuebioactivityandishydroxyapatitebioceramicmaterials.Thispapersum2marizesthestudysituationandthevariouspreparationmethodsofhydroxyapatitebioceramicmaterials.Thekeysareenhancementandpreparationanddevelopmentprospectofthesynthesizationofthecompositebioceramicmaterials.Keywords:Hydroxyapatite;Bioceramicmaterials;Researchsituation;Preparation;Developmentprospect20,,,(hydroxyapatite,HAHAP),HAP,,,,,,,,,,,,,,,1Ca10(PO4)6(OH)2,Ca/P1.67HAP,L6PCP63/m,(1),C,ab120,a0=0.9430.938nm,c0=0.6880.686nm,10Ca2+6PO43-2OH-OH-4,10Ca2+2,4Ca2+Ca(),z=0z=1/22,6OCa-O6Ca2+Ca(),z=1/4z=3/43,3O6PO43-z=1/4z=3/4,PO43-72006.No.2©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.…,1.641.65,5,,(pH=79),HAP,Ca2+Cd2+Hg2+Sr2+Ba2+Pd2+,HAP,HAP65%,HAP95%,,2HAP,-,2.1,pH,HAP,400600,HAPHAP,9001200,,,,,Ca/P,pH,,,,2.2--,-,,,,,,,,,-,,,2.3(),,,,,200400HAP,,,,;,,,,,,,,2.4,,HAP,82006.No.2©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(SHS)SHS,,HAPHAP,SHSHAP:n(Ca)n(P)=1.67,,,pH3,80,200,HAP340,,,,,,,,HAP3.1HAPHAP,HAPHAP:HAP,,900,,1300HAP,80m,HAP,,,,,,,10,,,,,,,,(),,,,540m;40100m;150m;200m;200400mHAP,,HAP,,HAP,,,,-,HAP,3.2,HAP,,,,,92006.No.2©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(300),,,,,,3.2.2CaHPO42H2OCaCO3,,HAPHAP:6CaHPO4+4CaCO3Ca10(PO4)6(OH)2+2H2O+4CO2,,,,,,,,3.2.3,,(651),2,,c(Ca(NO3)2)=0.042mol/d†c(NH4H2PO4)=0.025mol/d†1000ml,1254h,4256h,80mHAP,,,,,,,,,HAP3.2.4--HAP,HAP,-,(CaOCa3(PO4)2),,,Ca(NO3)2P2O5,,,,500,,3.2.5,,,,HAP,HAP,HAPCaO-SiO2-B2O3-Na2O,250350410h,pH7.3,,3.2.6HAP,110012003h,,HAP,,HAP,HAP3.3,HAP,012006.No.2©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(%)(MPa)KIC(MPam1/2)HAP-1001.0HAPHP(1100)HAP+20%Al2O3+5%Ni3Al-1602.3HAP,Al2O3,Ni3AlHP(1100)HAP+10%30%TiO294100962243.77.4HAPHP(1000)HAP+5%30%Al2O39699.7902501.42.5HAP,-TCP,Al2O3HP(10001250)HAP+10%50%(3Y)ZrO29399.51603101.03.0HAP,-TCP,-TCP,ZrO2HP(10501400)HAP/C-85-HAP,CHP(1050)2HAP+ZrO2HAP+ZrO2+BGAl2O3Si3N4(MPa)16018012015050060055599KIC(MPam1/2)2.24.61.742.0845HAP10,HAP,,,HAP,HAP,,HAP,,,,,4,HAP,HAP,,HAP,120,23,7%12%,,,,,,,,,,,112006.No.2©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(4):25262,..,1994(2):63643,..,2002(1):38434,,..,1996(1):45515,..:,20016KournoulidisGC,VaimakisTC,SdoukosAT.Preparationofhydroxyapatitelathlikeusinghigh-sppeeddispersingequipment.J.Am.Ceram.Soc.,2001,84(6):120312087,,..,1999,16():37398,..,2002(2):30349,,..,2002,30(5):56456810,,..,2002,30(3):38738911,,..:,199112ShirkhanzadehM.Bioactivecalciumphosphatecoatingspre2paredbyelectrodeposition.J.Mater.Sci.Mater.Med.,1995,6(1):909313..:,199814ZhangHG,WangL,YanYH,etal.CoatingofhydroapatiteonCaO-SiO2-B2O3-Na2Oglassunderhydrothermalcondition.J.Mater.Sci.Lett.,2001,20(4):53553715,,..,2002(12):1148115316..:,199417,,..,2000,19(3):28128718,,,..,2000(3):363919,,..,2003(2):3843(6)1998,,5.9L,,,,4.6L,(:4L/2L/),80%,(),1†1†1†,50%,,,,,,,,,,,,,1..,2005(9):42432,..:,20013..,2005(11):78212006.No.2