中药益母草药理学研究概况

:100422113(2005)0220146203,,(,010059):,:;:R2821710:ALeonurusJaponicusHoutt,,,,,,[1],,111111111[2],(OFR),,(MDA),(SOD)(GSH-PX)20minMDA,SODGSH-PX,60min40minST,CKASTLDH-LA-HBDH,,,[3]Ca2+-ATPNa+-K+-ATPMg2+-ATP,Ca2+,Ca2+,[4]11112,,,,[5]:(100200mgömL),(3001000mgömL)[6]112,,,,,[7]:2004209222;:2004204211:(1976-),,641ActaAcadMedNeiMongolJun.2005Vol.27No.2©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.PGE2,,,Ca2+,Ca2+,[8],[9](PDMT)(HAN),HAN,[10]113,TK,,[11]ADP,PGI2(PAF),PAF[12],,,,,,,,[13]114ConAT,B,14,1öd,6wk,,T,Tu,Tr,TuöTr,C3(LAK)(NK)[14],115,,,[15],116(14)[16],,[17]2,,;;;;;-[18][19],204080,,,,,[1]1()[M]1:,2000:2372238[2]HalliwellB.Freeradicalsantioxidantsandhumandisease:curiositycauseorconsequence[J].Lancet,1994;344(10):721[3],,1[J]1,1997;10(2):9211[4]1[M]1:,1990:174[5]1[J]1,1991;74120056272©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.8(4):2962298[6]1[J]1,1997;10(1):17218[7],,,1[J]1,2001;15(3):61262[8],1[J]1(),2002;31(2):1682170[9],1[J]1,1998;29(6):4142417[10]NagasawaH,InatomiH,SuzukiM,etal.FurtherstudyontheeffectsofmotherwortonpreneoplasticandneoplasticmammaryglandgrowthinmultiparousGRöAmice[J].AnticancerRes,1992;12(1):1412144[11],1[J]1,2003;13(3):1482150[12]PangS,TsuchiyaS,HorieS,etal.Enhancementofphenylephedrine-inducedcontractionintheisolatedrataortawithendotheliumbyH20-extractfromanorientalmedicalplantleonuriherba[J].Jpn.JPharmacol,2001;86(2):2152220[13]1NK,LAK[J]1,1996;16(3):141[14]1[J]1,1988;8(3):2192222[15],1[J]1,2002;33(5):41242[16],,1[M]1,2000:5062508[17]1[J]1,1987;22(8):3402344[18]1[J]1,2002;9(2):1812182[19],,1[J]1,2000;(11):37239THEPHARMACOLOGICALRESEARCHONMOTHERWORTHERBZHOUJing,AIMin,LILan2cheng(DepartmentofPharmacology,InnerMongoliaMedicalCollege,Hohhot010059China)Abstract:Motherwortherbisatraditionaldrugingynecology.Theuseofmotherwortherbhasbeenexpandedbyrelativestudyonitinrecentyears.Thisessayistointroducetheresearchofmotherwortherbinpharmacologicalactionandadversedrugreaction.Keywords:motherwortherb;pharmacology(:)841ActaAcadMedNeiMongolJun.2005Vol.27No.2©1995-2005TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.