绿原酸的药理学研究进展

NatProdResDev2006,18:6912694:100126880(2006)0420691204:2005206229:2005208224:(C03050205)3Tel:[phone];E2mail:[e-mail],,3,(,410078):(chlorogenicacid,CGA),,,,,,CGA,:;;;:R282.71:AProgressesinthePharmacologyofChlorogenicAcidWUWei2hua,KANGZhen,OUYANGDong2sheng3,ZHOUHong2hao(InstituteofClinicalPharmacology,CentralSouthUniversity,Changsha410078,China)Abstract:Chlorogenicacid,existinginmanyplants,hasvariouspharmacologicactions.Recentresearchesindicatedthatchloro2genicacidhasrelativelylowbioavailabilityfororaluse.Itexistsinplasmaintheformofmetaboliteswhichareexcretedmainlybyrenal.Chlorogenicacidhasmultipleactionsincludingantioxidant,anticancer,antibiosis,antiviral,immunomodulation,andhypoglycemicactivity,etc.Keywords:chlorogenicacid;pharmacology;pharmacokinetics;druginteractions(chlorogenicacid,CGA),,(caffeicacid)(quinicacid),CGA,,[1],CGA,,,CGA1Fig11Thestructureofchlorogenicacid1:,CGA,,CGA,,CGA[2,3]:CGA(HAS)[4],:,,HASCGA;,HASIIACGA:CGAOlthofCGA342,342,32242,,[5]P450[6]:CGA,,,CGA[4,5]©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[7]22.1CGA[1]CGA,,ox2LDL,CGA(ox2LDL)[8]ChlopcikovaCGA(Doxorubicin,DOX),DOX,(IC50)8.040.746.870.52mol/L[9]CGA,,2.2,CGA[10,11]CGA::JiangCGA,DNA,[12]:,,CGA[13]82(82OH2dG):82OH2dG,CGA42212(42nitroquinoline212oxide,4NQO)82OH2dG,82OH2dG[14]2DNA[13,15]2.3CGA(D),(NAT)[16219]CGA,CGAB37,3B5[20]ChiangCGA11[21]2.4CGA,[22]SDCGA,VitE[23]2.5ChiangCGA[24]BandyopadhyayCGABcr2Ablc2Abl,Bcr2AblBcr2Abl,CGAPhK562[25]2.6CGAT,2IFN2IFN[26228]CGAIgEIgG1IL24[29]CGA(cal2cineurin)[30]2.7Andrade2CettoAWiedenfeldH,CGA,3h[31]262[1,32]2.8CGA[33],(hypertrophicscar2derivedfibroblasts,HTFs)[34](ACTH)[35]EjzembergCGA,[36],CGA296Vol118©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[22],3CGA,,CGA(),[37]CGA[38],[39],CGAP4502B1,722422(72ethoxy242trifluoromethylcoumarin)[40]CGACYP2B6,,4CGA,CGA,CGA,CGA,,CGA,CGA,CGA,,,:,CGA,;,CGACGACGA,,CGA,CGA;,,,1ZhangAL(),MaQ(),GaoJM(),etal.Studiesonbioactivitiesofchlorogenicacidanditsanalogues.ChinTraditHerbDrugs(),2001,32:1732176.2OlthofMR,HollmanPC,KatanMB.Chlorogenicacidandcaf2feicacidareabsorbedinhumans.JNutr,2001,131:66271.3GonthierMP,VernyMA,BessonC,etal.Chlorogenicacidbioavailabilitylargelydependsonitsmetabolismbythegutmi2croflorainrats.JNutr,2003,133:185321859.4KangJ,LiuY,XieMX,etal.Interactionsofhumanserumal2buminwithchlorogenicacidandferulicacid.BiochimBiophysActa,2004,1674:2052214.5OlthofMR,HollmanPC,BuijsmanMN,etal.Chlorogenicacid,quercetin232rutinosideandblackteaphenolsareexten2sivelymetabolizedinhumans.JNutr,2003,133:180621814.6MoridaniMY,ScobieH,JamshidzadehA,etal.Caffeicacid,chlorogenicacid,anddihydrocaffeicacidmetabolism:glu2tathioneconjugateformation.DrugMetabDispos,2001,29:143221439.7HeX(),ZhaoTM().Pharmacokineticstudyonchlorogenicacid.ChinTraditPatMed(),1999,21:1612162.8ChangCQ(),ChenJD(),WangXS().Protectiveeffectsoforganicacidsonhumanvascularen2dothelialcells.ChinJPrevMed(),2001,35(2):79282.9ChlopcikovaS,PsotovaJ,MiketovaP,etal.Chemoprotectiveeffectofplantphenolicsagainstanthracycline2inducedtoxicityonratcardiomyocytes.PartII.caffeic,chlorogenicandros2marinicacids.PhytotherRes,2004,18:4082413.10ShimizuM,YoshimiN,YamadaY,etal.SuppressiveeffectsofchlorogenicacidonN2methyl2N2nitrosourea2inducedglandularstomachcarcinogenesisinmaleF344rats.JToxicolSci,1999,14:4332439.11MatsunagaK,KatayamaM,SakataK,etal.Inhibitoryeffectsofchlorogenicacidonazoxymethane2inducedcoloncarcinogenesisinmaleF344rats.AsianPacJCancerPrev,2002,3:1632166.12JiangY,KusamaK,SatohK,etal.Inductionofcytotoxicitybychlorogenicacidinhumanoraltumorcelllines.Phy2tomedicine,2000,7:4832491.13SzaeferH,CichockiM,BrauzeD,etal.AlterationinphaseIandIIenzymeactivitiesandpolycyclicaromatichydrocarbons2DNAadductformationbyplantphenolicsinmouseepidermis.NutrCancer,2004,48:70277.14KasaiH,FukadaS,YamaizumiZ,etal.Actionofchlorogenicacidinvegetablesandfruitsasaninhibitorof82hydroxy2deoxyguanosineformationinvitroandinaratcarcinogenesismodel.FoodChemToxicol,2000,38:4672471.15IgnatowiczE,BalanaB,VulimiriSV,etal.Theeffectofplantphenolicsontheformationof7,122dimethylbenz[a]an2thracene2DNAadductsandTPA2stimulatedpolymorphonuclearneutrophilschemiluminescenceinvitro.Toxicology,2003,189:1992209.16LoHH,ChungJG.Theeffectsofplantphenolics,caffeicacid,396Vol118:©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:1332139.17TsouMF,HungCF,LuHF,etal.Effectsofcaffeicacid,chlorogenicacidandferulicacidongrowthandarylamineN2acetyltransferaseactivityinShigellasonnei(groupD).Micro2bios,2000,101:37246.18LinXZ(),LiuCY(),ChenKS(),etal.ExtractionandcontentcomparisonofchlorogenicacidinArctiumlappalL.leavescollectedfromdifferentterrainanditsrestrainingbacteriatest.NatProdResDev(),2004,18:4082413.19DogasakiC,ShindoT,FuruhataK,etal.Identificationofchemicalstructureofantibacterialc