药源性肌病的临床表现及致病药物

!#!!#$!#%&$%%!!#$%&’()*+,%!-!#$#%&’&$#()*+&+#,$*&$-%&.*&+#/)-0.1*,(-0.12#$-.%)-’3,4&+53!#!$%&!’()*!&’()*+,-./01234!#!56()*+,-7801234!#!9!+,-./0123456789-:#;=?@AB123CDEFGH2.IJKLMNO-PQRSCD3TUVWXYZM.[\]#$%.I^./012^1_‘a&’()*+!#$!$%$&’,-./0+(,12*+!#$%&’()%)$!*$’:;&’()*+,-(.=?@A:BCD2EFGH#I:B2JKLMNO;PQRSTUVEWXYWZI[\]^;W_‘abcdefghijk:;lmno2mbpqrs2?tEuvwxyFz{|}GH~€‚ƒ„|k%…R:‘]†h~%…‡ˆ:;Fg‰Š‹ŒŽ2n%…n‘’N‹ŒŽ“n”†~:•A–ME—‹Œp˜2™šT;›FŽMœ•]:;2EFg:BCD;žŸ ~%…‡ˆ:;¡EAF¢2™£na¤¥¦2šT;›F§rsm¨‚©ªmbp~«‹Œ¬_2?%­]:;®¯L°2F±²³´2µ[n¶m¨~%­]:;F·‹ŒŽTM•]wœ•]:;/01~¸¹º‡ˆn»¼:;‹ŒŽa§;%…y|½¾i63456676bc012:•:œ¿aÀÁ:ÂÃÄ&23.ÅÆ*ÇÈÉÊ&ËÌÍEÎÏ3Ð0Ñ.ANÒӋŒŽ/!1ip˜|ÔÕÐÖ×Ø2™“g#IÙÚFÛ]2ÜÝ´ÞaßàF„%…á$2Fµ[;âã ~äå»wæç»èéÀê%A‡ˆë»:;ÒÓ%…~äå»%…:‘]FÛRìQíîïð&ñÄ409u…ò{gh/51~íîïðóô§áõö’Û÷øùrsnú2Aäå»:;wûü:ýþpÒÓ;žuž+çÿ~!2#$:;ž%&’¨€(äå»%…‡ˆ:;;ž+)ŸRõö’:;*¸|§/61~äå»èéÀê%+,g:‘]2™Nn%…:‘]g-n2./0äå:‘]–*/#12–123456570äåW890äå:‘]:Ö;0äåw0äå2n%…=?n@A]“FOu~ä廇ˆ:;ÒÓgBª‹ŒŽ/71C’ÀÁ23œÿD*ÇÉÊ2¡E«ß%mFE(ÍE56#I]:•2RFGHIœh2FgÀÁ23ÉÊ2ß%mFJ#E(2™šT;›ß%qK¤=mLFg:•p˜5MHN‡ˆ:•RÀÁ23Éʜ†h]5Oûü:ýþpMä廇ˆ:;P]Ž2™NQP]RSFTUV¤=~WOäå»:;XYefZ[/71%(’*\÷á$2F]§À%^È*ÇÉÊ56Ræç»èéÀê%ò$5MR2895:6ìQ\ò$2£_‘fWabfWcdbfWðefWg.hWidjkd~890äåW;0äåw0äåÒÓlmnof2895:6pqøù2m!‘%…rsA2895:6ìQ\GH2F§NÀ%^ÈÉÊ08!Ñ2tuᇈ%…‘]vwx«FÛ]yz{®~70äål|}mnof96#øù~~0äål289!2;pqøù2NR289!2;ìQ\£C!A’€\W‚ƒdfWgÊW_‘fd%I+†„y$…w†B‡ˆws‰/=1~äå»%…‡O:;rsŠFz{ûü:ýþaP]‹Œ2NOuŽnÊ2™¡EA§‘~’ä廥¦wt“\÷”•2–µ[R2895:6ìQ\aæç»%…ò$2‹—Ûn#˜Šrw™š$%2›4Ž:B=p˜¤œ/ž$%&’’!#!!#$!#%&$%%!!&’(#$%&’()*+,-./012%34567)*,89:;0=?@AB;67)*,CD#EFGHI%JK,67)*CDLM0N@O%&P,QRSTU12VW0$XGYZ[=?HI0\],67)*L^_8CD,+!#‘abcde,Ufg[=hi,jkblmFGnop^qrstlmuvFYZ[=0wxyz{|}~zv€6*‚ƒ+„|}v/a…l,M†‡ˆUwxyAG‰Š[zC‹Œ[zŽz‘’bhi“”•jk0–—˜[z™š›[zœ,-ežŸ xwxyXG¡¢hi£¤j¥¦*,b}•&.(§¨xz©•ªˆ/z«¬­®¯x¡bhi“”•jk0t°‡±²³*0´µ¢¶U!#de01fXg1f·¸•¶¹º\]AG1»ª?bhi¼l•jº½¾jº&2(¿tlmuÀ23UÁ)gJzjÂíkRBÄÅƱÇÈgl•ÉkÊ8ËÌU\]ÍÎÏÐÑÒzÓÔ½ÕÐÑÒ­j%Ö0t×#3kØbÙÚWÛÜÝÞsßjeàáWâãä8aåæ,¿1»ªçb}«åÇÈ °èéêë¢ìíî¹ïGsðhi,¼l•jº± 45- žñ1ò 6789óôõ,Íöìí ž÷‚²³ °,:9/2’ø/+#z17;ù‡Ùú¢¶&2(slmu±xy%¶¿\]!nû^ürbýþ0ÿ¾!ˆbïW#$?,%&U’()*z ƒ+„z+,-ˆz.ˆ!zÊ/ž ºz0123z45•6ež7x&22(z8[9¡¢hi¼l•jº‚¾jº,:;0W=ØU!$hij12¼?@WAB[ kC=0DEGFFGk?0HFIb}EJKž¢LM0NOHAGbhiJKžjkUJKžjk,ÙÚDEWjÒzj%Ö0¼lFPQjRœS067)*CD_8½×TLM0jUBbãjVWXY0±,=Z[hi,jk¢ð~\U¢]^_‘&2!(0taAB[ kC=bcd?@zef?@‚g0Yh¡bÙÚ‘JKžC•Ujklmn0i­j!0ä8bklU!%kl12Omn‘opqrstuv&2(0wx$jRzyz{²³‚|}~€{²³×‚&2+(0©òƒë¢qrC•0êbhlqrjk0bÙÚWj„…½tl†7‡ˆ0‰¢ÑÒzjŠÖ‹vzŒŽ½‘’­v“6*U!&mn1op012”zî¹6•zY?=­–•„ˆbhiVWjÒ*&2;(0ÙÚW°‡~&,öjRŒÒz—˜z™•„š‚~}TÖ9012!nb›¦U#73456#!qgrst12ÿ¾!ˆahiPQjk,DE°‡Utlœ412bžŸoû½o 0DE¡¢F=,•!‚XGxy0£¤d¥‚¦§0¨,jC•áw&2(0©±Gxy&’˶U12-./0|xyˆhijk,lmuÊ8v&2#(Uÿ¾!ˆjk,Á)*+bÙÚW€Yª4hi,áW«¬,PQjR­®zVWY‚j%Ö0ÓÔ¯j°W&’0b±ôi²ÝÞ³^´)~iU‡j%Ö$·¸•Ék\]×áW8ã0µÿ¾!ˆ8GF·¸•Ékb·¸•¶¹ºz¶·•¸¹º»­¼l•jº,?0¼½Á)?¯¾1@,ÞTU¿À0ÿ¾!ˆhi,v“6*zÁŒ´µ­ ·¸=z Â9˶,j%ÖXÃÄÅÆÇWþÈUtDEÁ)gJ$F%×ɂûÊqr,*+ÙÚz67)*_8½Ëvz67¦!CD_8­ˆyXG½!Gnjk*+’ÌÍÎ90jÂÃBÄÏ¢$FÃÄ0œSBÄbãÐÑ,!/jVW­®012~hij“”½Òm&2(U¢]^_‘0Óy,†7bi1@,ÔÕïG0°tÓGF·¸•¶¹º\]Uÿ¾!ˆjk¡b¢t֕ÙÚ&2(0×ØW֕ÙÚÛܕjk0ä8$wxyAGÿ¾!ˆjlm0t×wÐÝkØa$óGÊÞßYqrjRàáxj‘Ú,0jVW×j 45•ã’atÐÑkRgJUÁ)ÙÚW᫬j%Ö0bà­äåj067)*CD’ÌLM9U##kl12wxyAGæçzèæçbhiqrjk&2(0%jÒ*+U¢]^_‘0·¸•Ék\]Xéê!#$$./012!-&3!456!#$%&’(’)*+,%&-./*0&-%12/%3+%&14*1*/%,0*+2$’#&2%*-&%/&*uvw!#$%&’()#!#$*!:#xyz{k|}.I7H~.!#3$:%#-&’z{k2.(z)*.7H~.!#3CDEF(e+NOG,-.Jz/0.123U453S67t(CDEFG,-L8;y]!#!!#$!#%&$%%!+,-./0123456789:;&’=?@AB+.C:D64EFGC4HIJK34LMN6OPQRSTAUVWXYZ[P\]^W_‘abcd=e6fghi4jklE1mn3op3qr3AYZstuvnwoxyqz{|}E~()€‚ƒ„…†‡ˆ3‰Š‹ŒAU34Žehi‘’“”•–)—˜™‹Œtuvš›5œN34Ež.*5+Ÿ DFGC?@534klA¡¢£A¤¥¦§n3YZ¨D¥©ªª«¬­N5E®€¯°¤±²†³´µ¶·¸¹ºƒ»¼½V¾A/0œN34,&-.efghiklƒB+.C D67Atuv¿ÀNJK3ÁÂoÃKÄÅÆÇÈo~()€‡ˆÉEž./5+fD3ÁÂklAÊË£fghiklÌÍÎÏÐѤ¡¢EÒÓ¤¥§oÔ:?@ÍÕÖº5×ØNE89,-,&.012345%6789:;%=$86?4@A3B:;C8DE;8348D5EFC7834G:HC78AHD8HE35:3:4HAI8D;J:2:;H2?,K.$881HÙ6?4I4F?L!HD8;DM,6.$888888888NHF;I%KO7%P5AHQ:H:%K5RC34HF%(L;DCM7%%62O5ASTU:II7%%%%%%%%%&VV-Ù&+V-T&-!#$,!.W2A5%67%6X4RDAI%Y7%ZABI[\:C3%]$%U6O%(^K85;DE23AC;T8:HB::345C8AHD8R?434G:2:3?,=.$8Z5EF89AJ;3?78!78!!L+MÙ//&$,*.UA5F5;A\;C81788U;AI;C89$8893A3:HC8AHD8R?4@A3B?,=.$88_AH2;3788!!788*#VL!MÙ-&&$8,/.NHFIAHD8=Z78‘AICB8=(7893;SA53878;38AI$86:342B4HD5:AI8R?T84@A3B?8D;\;I4@:HF84H835;A3R;H38S:3B83B;8U6O8(^K85;T8DE23AC;8:HB::345CTC:R\AC3A3:H8AHD8@5A\AC3A3:H,=.$8KEC38a8b8=886;D788&VV#788L/M!#Ù*-/$,#.93AJJA8=K78(BAHF8=788O5;;H8_$88(;5:\AC3A3:H8AHD85;@453C84J88JA3AI85BAD4R?4I?C:C,=.$88a8NHFI8=86;D788!!788*/+L-MÙ#*V$,+.K5F4\78b$8Z5EFT:HDE2;D8R?4@A3B:;C,=.$88(E558^@:H8a;E54I78!788&*L#MÙ#/&$,-.(B4HF8U7889;;F;58=Z788P5AHcI:H8($8(I:H:2AII?85;I;\AH38D:JT8J;5;H2;C8;3S;;H83B;8C3A3:HC8:R@I:2A3:4HC8J4583B;5A@;E3:2T8C;I;23:4H,=.$8KR8=86;D788!&78&&&L#MÙ*V$,d.0E8Z7886E53?8678862R455AH86$893A3:HCÙ5BAD4R?4I?C:C8AHD8R?4@A3B?,=.$88(AH86;D8KCC428=78!!788&++L&MÙd#$,V.(4[E;38678eAHHSADB8e78U;H:H8Z$86?4@A3B:;C8R;D:2A8R;H3;EC;C8;3834G:[E;C,=.$88];\85A3788!&78#&L*MÙ!-d$,&.88)4IC:8]78eABI4EI8b788UA2B:2BA8=78;38AI$88Z;5RA34@4I?R?4TC:3;8:HDE:3;8@A58IA8Z@;H:2:IIAR:H;8AE24E5C8D;8&A8@4&?A53B5:T3;85BERA34:D;$8K8@54@4C8DfEH82AC8;385;\E;8D;8I:3;5A3E5;,=.$8];\88]BER86AI8