远志的药用价值及开发研究

84()Vol.8No.420078JOURNALOFBEIHUAUNIVERSITY(NaturalScience)Aug.2007:100924822(2007)0420322206,,,,,,(,132013):.,,.:;;;:R932:A:2007204215:(1978-),,,.,(Polygalaceae),(Polygala),(PolygalatenuifoliaWilld)(P.sibiricaL.).500,.42,8,,[1].,(Polygala.arillataBuch2Ham);(P.arvensis)(P.glomerata)(P.wattersii)(P.japonica)(P.snboppositaS.K.chen)(P.wattersiiHA=ance).,..1,:,.,,,,,,,,,,,..:.,,,,,,,,.,..,,,,..:.,,:,,.,,,,,,.100g,3,,,1,,;6g,10,,1,.,,[2].22.12.1.1,.,80,,.ABC,19981999[324]5,2D,3D,5D,3C,H[526].©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[7],,,.70[8].1999[9]4,ArillatanosideA2D,1(Polygalas2aponinXXXV).2.1.21160,(54).8,3[10].22,D(arillaninD),E(arillaninE).2.1.31994IkeyaY[11]4.1997ZhangD.M[12],glimeratoseA2D.2000[9]5,3,A2C(arillanin)A2C.,.,(),5.[13].2.1.4,,1993[14]7,.1222,6N9212221222Perlolyrine.2.1.51994[15].[16].2000,.2002[17],1,F;1,2.2003[18]22,,55.,18,51.57%,n224221,12,21.52%,6.19%,4.00%,3.09%,1.94%1.4%.,3,4,52(TMCA),3,4,52(M2TMCA)(P2MCA),TMCA.,.2.1.62001[19]2Zn,Cu,Fe,Mn,K,Ca,Mg.:Fe,K,Ca,Mg.Mg,6.2.22.2.1[20]1mA,417d.21d,,(AChE),.:,AChE,AChE,AChEACh,,.[21],,..()30%,[22].[23]D2,(SOD)(GSH2Px).,SOD,GSH2Px,3234,:©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[24]D2,30,3().(mL0.6g)0.3mL,25d.24,252,26.,SOD,(MDA).,,;;,.[25]ig60d,M,,.4.28g/kg,.59d,.(NAD+),(NADH),[26].(SAM);,.,KCN,,[20].,P(LPS)(TNF2)21(IL21),CNS,[27229].2.2.2[30],(Tenuiifolicsaponin,TS).(RVHR)(MAP).:TS2,4,8mg/kgiv2040mg/kgigMAP31%,37%,50%,21%31%;TS40mg/kgigRVHR6090min38%26.8%,2h3h.DipAtr/ivTS,TSEip.TS,2M2H1.,(TG)(TC)[31].H,19.3876mol/L20%,23%34%,17%,20%35%,[32].H,,Langen2dorff,,,.2.2.3[33](g/L).(0.390.11)m/L,3D(5,10,20mg/kg)(0.770.37)m/L(P0.01),(1.210.63)m/L(P0.01)(1.701.00)m/L(P0.01).3D,.2.2.4.[34],,.,,[35].[36]4.;2D,3D;5D;3D.,.[13]2,4,62.2.2.5(SCE),.:1.0mg/kg,SCE,,..[37]IL22,DNA423()8©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[38239].AmseB1,TA98,TA100.[40].,2.5mg/mLYac21,K562,L929,[8].2.2.6.3,282,Senegasaponina,bSeneginII.:,282O2[39].2.2.7[41],(0.9g/kg)(0.4g/kg)(0.9g/kg),[42][43],...,3,4,52(TMCA)3,4,52(M2TMCA)(PMCA),TMCA[44].2.2.8.[3H]SCH23390[3H],[3H],[3H]QNB[3H]muscimol.Scatchandplot[9].2.2.9,,.,,.,:,,0.75g.[45]..25g,15min,,3min,43,[46247].,.,,,,,[48249].[50]1,322227221222,3,.[51],,.1,7222,32.1,7222,32,[52].2.2.10,,[53].,LD50(10.031.98)g/kg,LD50(16.952.01)g/kg,75g/kg.100%LD5022.52g/kg.,,.,.,,.,..,,.,,,.5234,:©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[1],,.[J].,2002,16(6):42243.[2][S].:,2000.[3].H[J].,1999,34(4):2412243.[4],.[J].,1998,33(8):491.[5],.[J].,1998,33(8):491.[6].H[J].,1999,34(4):2412243.[7].[J].,1993(11):675.[8],,.D[J].,2000,17(1):41246.[9],,.[J].,1999,21(3):3572363.[10],,.[J].,2002,12(5):.88293.[11]Ikeya,SugamaK.FourNewPhenolicGlycosidesfromPolygalatenuifolia[J].ChemPhamBull,1994,42(1):230522308.[12]ZhangDM,Miyase.OligosaccharidePolyestersfromrootsofPolygalaglmoerata[J].Phytochemistry,1997,47(1):45252.[13].2,4,62[J].(),2003,18(2):75.[14].[J].,1993,18(11):6752677.[15]XLShen,MRWitt,KDekermendjian,etal.IsolationandIdentificationofTetahydrocolumbamineasaDopamineReceptorLigandfromPolygalatenuifoliaWild[J].AetaPharmaceuticaSinica,1994,29(12):8872890.[16],,,.[J].,1992,24(8):4772479.[17],.[J].,2000,23(1):35237.[18],,,.GC2MS[J].,2003,25(4):43245.[19],.[J].,2001,7(4):32.[20],.[J].,1993,13(5):3012303.[21].[J].,1993,(6):28.[22],,,.()[J].,2001,13(5):3162318.[23],,.D2)[J].,2002,23(1):4.[24],,.D2[J].,2002,33(4):35236.[25],,.[J].,2002,37(12):9132917.[26],.,[J].,1991,12(5):2882290.[27]KimHM,LeeEH,NaHJ,etal.EffectofPolygalatenuifoliaRootExtractontheTumorNecrosisFactor22secre2tionfromMouseAstrocytes[J].Ethnopharmacol,1998,61:2012208.[28].[J].,1996,19(1):20.[29].78[J].,1994(6):24.[30].[J].,1999,20(7):6392642.[31].[J].(),1996,18(2):36.[32].H[J].,1999,34(3):2412243.[33],.[J].,1998,33(8):491.[34].[J].,2001,9(8):45246.[35],.[J].,1997,19(1):35236.[36]XLShenMRWitt,KDekermendjan.IsolationandIdentificationofTetrahydrocolumbamineasAdopamineReceptorLigandfromPolygalatenuifoliaWild[J].AetaPharmaceuticaSinica,1994,29(12):8872890.[37],,,.[J].,2003,29(30):2582260.[38],,.[J].,2002,12(5):88293.[39],.[J].,2002,10(4):2852291.[40],,,.102623()8©1994-2008ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[J].,1990,15(10):41246.[41],.[J].,2005,27(6):7282730.[42].[M].:,1991.333.[43].[M].:,1991.329.[44].:[J].(),1996,18(6):39240.[45].[J].(),2001,23(3):155.[46].43[J].,1996,16(10):633.[47].[J].,1995,15(1):57.[48].1[J].,1993(4):246.[49].[J].,1994,8(1):8.[50].[J].,1997,32(5):3602362.[51],.[J].,1998,15(6):5012505.[52],.[J].,2002,10(4):2852291.[53].[J].,1995,11(5):107.MedicalValueandDevelopmentofPolygalatenuifoliaZHANGMin,GAOXiao2hong,SUNXiao2meng,XUJia2tong,LIXiang2yan,SHIYan2jie,FANXin2tian(PharmacyCollegeofBeihuaUniversity,Jilin132013,China)Abstract:Polygalahashighvalueofapplicationinthepharmacognosy,pharmaceuticalchemist