革兰阳性球菌医院感染的体外耐药性监测

(,438200):,,;(K2B)3186,,30.1%22.0%;186,(MRSA)17,20.7%;(MRCNS)25,39.1%;MRSAMRCNS,:;;:R378.1:A:100524529(2005)0120110202InvitroDrugResistanceofGram2positiveOrganismsinNosocomialInfectionFENGHan2bin(XishuiCountyPeoplesHospital,Xishui,Hubei438200,China)Abstract:OBJECTIVEToinvestigatethedistributionanddrugresistanceofGram2positiveorganismsinfectioninourhospitalandofferscientificbasisforreasonableusageofantibiotics.METHODSTheorganismswereisolatedfromthespecimensbytheroutinemethods.ThedrugsusceptivitywastestedbyK2Bmethod.RESULTSAtotalof186strainsofGram2positiveorganismswereisolatedfromtheclinicalspecimensduringthelast3years.Theseorganismsweremostlycamefromurologicaltractinfec2tionandsurgicalorwoundsiteinfection.theywereaccountedfor30.1%and22.0%,respectively.Amongthe186strains,meticillin2resistantStaphylococcusaureus(MRSA)were17strains,whichwere20.7%ofthetotalS.aureus;Meticillin2resis2tantcoagulase2negativeS.aureus(MRCNS)were25strains,whichmeant39.1%ofthetotalcoagulase2negativeS.aureus(CNS);thevancomycin2resistantGram2positivestrainwasnotdetected.CONCLUSIONSTherateofdrug2resistanceamongMRSAandMRCNSwashigherthanmeticillin2susceptiveS.aureus(MSSA),soweshouldattachimportancetosupervisethedrug2resistanceofGram2positiveorganism.Keywords:Gram2positiveorganisms;Nosocomialinfection;Drugresistance,,100,1,,200112003123,186,11.118656(30.1%);41(22.0%):2004206218;:2004208214;40(21.5%);37(19.9%);12(6.5%)1.2(PEN)(OXA)(AMP)(ERY)(CLI)(NIT)10g(GEN)(AMK)(CIP)(CHL)(VAN)(SXT)(TET),1.3MH,1.421.5(K2B),011ChinJNosocomiolVol.15No.12005(NCCLS)2001ATCC2592322.1186,82,(MRSA)17(20.7%),(MSSA)65(79.3%);64,(MRC2NS)25(39.1%),(MSCNS)39(60.9%);40,21(52.5%),19(47.5%)2.2186111111(%)MRSAMSSAMRCNSMSCNS100.081.5100.076.952.473.6100.00.0100.00.033.347.447.123.176.051.352.97.748.020.552.484.20.00.00.00.00.00.023.53.124.015.419.026.35.93.14.00.033.363.282.47.784.010.357.194.770.633.848.020.594.147.788.066.7:33.1,,,MRSAMRCNS(VRE)325MRSAMRCNS,2,MRSAMRCNS,6:MRSAMRCNSMSSAMSCNS,,,MRSAMRCNSMSSAMSCNS,,KB,NCCLS,MRSAMRCNSMSSAMSCNS,,MRSAMRCNS,,73.2,,,,,,VRE,,,,,,,,VRE:VRE,(GISA)(GR2SA)8,VRE,VRE:1,,,.2J.,2003,13(1):426.2,.S.:,1997.4742486.3,,,.PCRDNAJ.,2003,13(6):5142516.4.J.,2002,12(4):3122313.5,,.J.,2002,12(10):7972798.6.J.,1999,20:1782180.7,,,.J.,2003,13(10):963.8,,.1131J.,2003,3(4):2402242.1112005151