碘摄入量增加对甲状腺疾病影响的五年前瞻性流行病学研究-滕晓春

..【】。19993,()、()、(),3761。、B。2,80.24%。(1)1999,()3.57.3;3.26.6;35,511.3】2.6;(2)1999,(T)3.86.2;AIT54.45.5;(3)3、H,54.210.3;(4)3();(5)19.37/10,。。,200L。6〕g/L。【】;;;pactofleInke。。dldis”eS—Aflve.yaerPrcdveelPdendo】tUSdyWC.,rEN,SNZhDn,`NaHi-x,uYshu,YUXh,Chenilgn,CONCi,`aFn,iL,,Nsognchen,oH,MAOn.。,`UXn,YUaYng,U,aYnn,Z0oDgn,`oRgn,IAJNCaY“,lLChengn,W`i.gn.。meofiron,eiFsrtldetoHi,ittEirno,Canerdlsr,5ng11《)1coeSIngaho:rTEN`ng【A。,ct】0eveoTvealuateeelr。、pwteeniineintakelevelandtheoceuneeanddeveloPmentofthiddiseases.MethDuirngthepe6of1999~2X(,acorsscseitonalsuVreyin1999andasyaerfollowuPsuveryweereodnuetedinthe3eommuniitesthdiffeerntidoineinelevelsinChina:Panhsan(lddeieney),Zhang1.(moerthanadequaet)dHuanghua(iodineexcess).AtoOf3761subjeestweerincludedin1999and80.24%ofthemPaztieiPatedinhtesyearfollowupsuveryin20(.hTele5Ofseumrhytiordhomresandthyoridautoantibodieswemeasu,andthyroidBult~undwasformred.ReStS(1)epveraleeofvoerth,thymiidsminl999inzh,uHuanghauwas3.sand7.3itmes,andthatofsubCliealh”thyoridismaws3.2and6.6timesashighasinPanhsan,`ctively.es-yeumulveicnideneeofsubCliniealhypothidismwas11.3and12.6itmesashighasinaPnhsan,butnodercneofineideneeofoverthythyoridismawsfound.(2)hTepervaleneeOfautoimmunethyY’Oidiits(A)in1999inhZangwuandHuanghuaaws3.8d6.2times,andthes~yaereumulativeineidecneofAaws4.4ds.sitmes。ihghasinPanshan.(3)Duirnghtesearfollowirdo,theineideneoOfhythiidsminsubjcetshtsiitvethyt’DidordaseantibodyandeuthyoridisminZhanduHanghuaweer4.2and10.3itmesashigh:(cMB9888);(39970350、30240013、30378。);(2003225005):11el,,(、、、、、、、、、、、、、、、、、、、);();(、):asinPanshna.(4)No51,iifeantdercnesinhahtpervaleneein1999andsyeareumulativeineideneeofoverthyrthidismweerfoundinthe3eommunities.(5)hTeineideneeofthideaneerwas19.37/lX()X(ryearinHuanhgua,andalloftheeasesweerPaPillayrthyorideaneer,andnohtyorideaneerwasfoundinZhangWliandHuanghua.CondonMoerhtanadeateorecxessivedietidoineintakemindueeandpormotethecoeuerrneeanddevelopmentofhypothidismandAIT,theerfoer,medianuirnayriodineexeertion(MUI)moerthan20()Linthepulationasrnotsafe.hTeobsevrationthatahigherineideneeOfthideacnercoeurredintheidoineecxessiveaerasiwhtMUI6X()Ldesevresfurtherivnesitgation·tKwor1Idoine;hTyoriddiseases;orPseitvestudies;Epidemioloigestudies(hCinJEeirnoljtab,20(,22:51217)。1993,7.27,800,18。19%(Univesralsaltiodination,USI)。USI,(MUI)USI165L(1995)330L(1997)306g/L(1999)。USI20.4%(1995)8.5%(999)。,USI,t2]。,19971999,24Mm200g/L,14Mul300L[’]。(MUI100199)L,“”“”[’]。usl,。,,1999(iodineindueedyoriddiseases,IITo),、3,3761,20,、。、(l)19993:(,MUI83.5)L、(MUI242.9)L,(,MUI650.9L)。31314(16287),31103、1554、1074(3761),(、、B)。3、,,、、,105[]。20199937615,3018,80.24%,380.15%、80.18%、80.45%。1999,3,、、。3[`〕。、、13(1999)(2X()4)Tab1Demophieehaacrteirstiesandiiodnenutirtionstatusofthe3popationeohortoattheoirig(1999)andfollowupsuvrey(20()AresiTmeofassay:nM:F()()Age(arnge)yea)()Iodineind“nkngwaetr(n)(L)Iineina】t(mkg)MUI(『L)Assayedcohott.ChildnJ6gn,Oàj,,`joj8824216563l:2.8836.21:3.1641.8)8.2(l)10.0(83.3.103.196.7JJ6`3743506146356Qù:44、àùPshanZhangwuHuanhgual:3.2239.8l:3.37.4l:2.9137.0l:3.2642.212ll13l26(1489(19l2(1453(1948(1490(1934.6(27.8(6417.0)l12.4)413.9)610.0)12.12-201.8(174.760.5201.8(167.605.75610.0ù、à6、à054452325J44044nù000,61QJ,`nùō.`..1,.1:M:Male;F:Female;MUI:Meidanofuirniine;.810810yeoldehild,(n6())514·212226ChinJEndOCrinolMe,DecemrZ,vol22,No.62、、、1b2MehtodsOfass,cnearnandeoeeientOfvairiaton(CV)forhtyoridhomronesandautoanitbiesehtedRefeneenIassayCVAalncalsesnitiytICMAICMAICMAICMAICMAICMARRA0.34.8mIU/L10.35Pmol/L2.3.3PmL50.0IU/40.0IU/0.88.0L2.IU/L1.23%1383.44%82%1.,8%22%3.51%465%3.86%.06%3.00%10%5.67%.84%InetryCV1.57%4.93%6.55%,38%474%.35%6.22%.29%5.82%.78%4.71%14%8.64%45%0.(X)2mIU/L3.9pmOI/Ll,5Pmol/L7IU/ml10IU/0.2L.b、ó,POAb:hT”ideP。d,,ity;:idglobiuln;b:6by;TRAb:HHcerePofranibty;CIMA:Chemilunces,timmuonasasy;RRA:RadioeptorBSa8,(ICMA),DPC(2)。v[](WS/T107-1999),68、152、218L,CV6.68%、6.53%、2.14%;CV2.01%、2.52%、2.31%。MedisionSA00,7.5MH。~B、、、,B,。「5」。、Ecxel,SSPS11.5。,(SNK),H,(h“kalWaUisH);istic。0.05。、()199939,121。3t6〕(3)。2004,35(3)。(0.47%。0,=4.09,0.04)。,11.312.6(3)。`:(oR3.0,95%cl1.66)、H2mIU/L(OR6.6,95%CI3.l14.1)、(OR10.7,95%lC1.49.7)、(oR=9.1,95%a1.29.7)。1999121100,82.64%。。29%[342.86%、40.48%、17.65%,(x,=5.%,0.02)〕;5%(30、9.52%、1.%%,,);66%〔357.14%、45.24%、78.43%,(x,10.94,p0.01)]。gtic:H6mIU/L(OR=3.4,95%lCl,l10.5)、(OR5.3,95%cl1.8.7)、(OR=8.0,95%a2.55.4)。、(Arr)1999,Arr3.86.2(3)。5,Arr,4.45.5(3)。,、、3(OAb)(Ab)(3)。1999213TPOAb(H),579.35%,,。3,TPOAb(65.31%)(83.93%)(84.81%)(x,=4.56,=0.02,x,=6.57,0.0);224TgAb5Ab73.47%,TPoAb,Ab,,3TgAb(723%、68.24%、84.X()%,P0.05)。(H)(,STH0.3mIU/)L(H4.8mIU/L)(8.45%,1.35%,x,=62.53,p0.01;5.99%1.73%,x,=21.90,p0.01)。1999、、TPOAb()50IU/ml)(H4.8mIU/L)7%、18.06%30.63%,,,3a[J,PTOAb:PTOAb,。2X()4:、、3H、OAb,51.64%、10.59%、16.00%,3(9.30,=0.01)。、1999、、3(3)[9〕。rGvaes383.3%、62.5%、92.3%;3,Garves,3Garves。、2X()4,53、Garves(3)。20(92(80%),,5.43%,19.57%,71.74%,3。915:H0.3mIU/L(OR5.7,95%lC2.115.0),TPOAb(OR=3.8,95%lC1.7.8)(OR=3.1,95%CI1.4.8)。、19993:、,or(1,9)。,or。1994。20043,、,513(2,fl),,。,19942004:9.22/10、18.43/10、18.40/10、0、0、9.