组织工程支架材料

(430070),,ScaffoldmaterialsfortissueengineeringYenWenLongSunEnJieGuoHaiYingLiuDongDepartmentofBiologicalScienceandTechnology,WuhanUniversityofTechnology(Wuhan430007)AbstractDevelopmentinresearchesofScaffoldmaterialsfortissueengineeringarereviewedinthispaper.Thesematerialsincludenaturallyderivedonessuchascollagen,polysaccharidesandinorganicmaterialsaswellasdegrad2ablepolymerssuchaspolyesters,polyamidesandpolyethyleneglycol.Keywordstissueengineeringnaturallyderivedmaterialdegradablematerial,,,,,[1]80[2],199035[3](ex2tracellularmatrix,ECM),,:1,,(),,1.1,,,,FDA,[4],,,,;,[5](RGD),[6][4][7,8],,(solidfreeformfabri2cation,SFF),,1520042511.2,,[9],,,,,,,,2D2Mannuronte(M)2L2Guluronate(G),GMGMG,,G,MG,M/G,M/GG,(Ca2+)G,(eggbox),,,,,,,-,,2,,[10]1.3,(HA)(tricalciumphos2phate,TCP)[11],I,(calciumphosphatece2ment,CPC),,,,,,CPC[12](trueboneceramic,TBC),(HA)HATCP,TCPHA,,,/(TCP/HA),[13]2,,2.1,(PGA)(PLA)(PCL):,FDA,,,,,CO2H2OPHPGA,;PLA,PGA,PGA,PGAPLAPLGAPGAPLA,,,RGDPLA,[14]BMP,PLA[15]PLAPEO,PEOPLA252004251,;PEOPEO,2,,[16]PGAPH,,,pH,,PGA[17]PCL,Kweon[18]PCL,,,,MG2632.2,:,,,,,[19],,,,,,,,,,,,,,,,,,2.3(PEG),,,,,[20],,,/(PEG/PBT)PEG,;PBT,PEG/PBTCaP,,CaPCa2+PO43-,,(HcAP),HcAp,,,,[21]3(ex2tracellularmatrix,ECM),,[22,23]:,,,;;;;,,,[24]:1.,2.3520042513.,,,;,,,,1LangerR,VacantiJP.Tissueengineering.Science,1993,260:92029292HelenH.Lu,MichelleD.Kofron,SaadiqF.El2Amin,etal.Invitroboneformationusingmuscle2de2rivedcells:anewparadigmforbonetissueengineer2ingusingpolymerbonemorphogeneticproteinmatri2ces.BiochemicalandBiophysicalResearchCommuni2cations,2003,305(4):88228893MillerMJ,PatrickCW.Tissueengineering.CLINICSINPLASTICSURGERY,2003,30(1):914BadylakSF.Theextracellularmatrixasascaffoldfortissuereconstruction.seminarsinCELL&DEVEL2OPMENTALBIOLOGY,2002,13:37723835HendrenWH,RedaEF.Bladdermucosagraftforcon2structionofmaleurethra.PediarSurg,1986,21:18921926Byung2SooKim,CarlosE.Baez,AnthonyAtala.Biomaterialsfortissueengineering.WorldJUrol,2000,18(1):2297PieterBuma,JeroenS.Pieper,TonyvanTienen,etal.Cross2linkedtypeIandtypeIIcollagenousmatricesfortherepairoffull2thicknessarticularcartilagede2fects2Astudyinrabbits.Biomaterials,2003,24(19):3255232638GerburgKeilhoff,FelixStang,GeraldWolf,etal.Bio2compatibilityoftypeI/IIIcollagenmatrixforperiph2eralnervereconstruction.Biomaterials,2003,24(16):2779227879GomesME,GodinhoJS,TchalamovD.Altern-ativetissueengineeringscaffoldsbasedonstarch:process2ingmethodologies,morpholoy,degradationandme2chanicalproperties.MaterialsScienceandEngineer2ing.2002,20(122):1922610ElcinAE,ElcinYM,PeppasGD.Neuraltissueen2gineering:adrenalchromaffincellattachmentandvia2bilityonchitosanscaffolds.NeurologicalRes,1998,20:648265411,,,.Interpore500R.,2002,18(2):160216212YoshikawaT,SuwaY,OhgushiH,etal.Self2settinghydroxyapatitecementasacarrierforbone2formingcells.BiomedMaterEng,1996,6(5):345-35113,.-.,2002,25(5):227-23014,,,..,1999,13(2):99210415DragooJL,ChoiJY,LiebermanJR,etal.Bonein2ductionbyBMP22transducedstemcellsderivedfromhumanfat.JournalofOrthopaedicResearch,2003,21(4):622$62916,,,..,2001,14(4):488-49217AnitaW.T.Shum,ArthurF.T.Mak.Morphologicalandbiomechanicalcharacterizationofpoly(glycolicacid)scaffoldsafterinvitrodegradation.PolymerDegradationandStability,2003,81(1):141$14918HaeYongKweon,MiKyongYoo,InKyuPark,etal.Anoveldegradablepolycaprolactonenetworksfortissueengineering.Biomaterials,2003,24(5):801280819M.Borkenhagen,R.C.Stoll,P.Neuenschwan-der,etal.Invivoperformanceofanewbio-degradablepolyesterurethanesystemusedasanerveguidancechannel.Bioma2terials,1998;19(23)2155-216520,,,,2000(1):39-4521,,,2002(5):3042311(41)452004251,,,NT2SMA,314:(),4,NT2SMA,,,,5,,,6NT2SMA,,,,,7NT2SMA,5,,,,,:,,,();,,,10%,20,NT2SMA:,,,NT2SMA(:04201208)(50)irradiationprocessingofhydroxyapatite/poly2L2lac2tidecompositebiomaterial[J].RadiationPhysicsandChemistry.2003,67(324)375237930,,./DL2[J]..2001,20(1):2322831,./[J].2002,33(3):261226531,,.2[J]..2001,13(5):5172520(:03211211)(54)22ToddC.Holems.Novelpeptide2basedbiomaterialscaffoldsfortissueengineer-ing.Trendsinbiotech2nology,2002,20(1):1622123E.Sachlos,N.Reis,C.Ainsley,etal.Novelcollagenscaffoldswithpredefinedinternalmorphologymadebysolidfreeformfabrication.Biomaterials,2003,24(8):14872149724,2002,8(5):257-260(:03211226)142004251