微渗析技术

333(300071),,333(microdialysis),[1]70,1991,,,,1Fig11Microdialysissystem1(),1:,(0155L/min),,,(perfusion),,,,(recovery);,(delivery),,1,3[2][3][4]3,01510mm,,[5][6][7][8][9][10],[11][12]0817419987FENXICESHIXUEBAO(JournalofInstrumentalAnalysis)©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.[13][14]2,,(recoveryrate)(cd)(co):R=cdco100%,cdcoMorrison[15],,,,cdco,,,,Lunte[16]01211cm/s,,,(invitro),,,(internalstandard)[17],(deliveryrate),[18],,(lowperfusionrate)[19]50mL/min,,90%,100%,3:(1),;(2),;(3),(extrapoiation)[20],,,,(pointofnonetflux)[21,22](zeroflux),,,(),,,,68h[23](deliverytest)[23,24],[24],,,JusticeJr,33,[25][26][27][28][29][30][31][32][33][34,35]18174(1998)©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.[36][37][38][39][40][31][41][42,43],,[44][45],,[27,46],[33,47],,[48];,[49];[40],[31][50]Kissinger[51],,,[45][52],[53,54],4,:,[40],,,,,,,,,,,,1LunteCE,ScottDO,KissingerPT.AnalChem,1991,63(15):773A2ScottDO,SorensenLR,LunteCE.JChromatogr,1990,506:4613Telting-DiazM,ScottDO,LunteCE.AnalChem,1992,64(7):8064AultJM,RileyCM,MeltzerNM,etal.PharmRes,1994,11(11):16315AcworthIN,YuJ.JLiqChromatogr,1994,17(3):6856YasuakeT,MotokoY.JMassSpectrom,1995,9(10):8957AmineA,DiguaK,XieB,etal.AnalLett,1995,28(13):22758VanderKuilJanHF,KorfJ.JNeurochem,1991,57(2):6489NaeslundB,AmerP,BolinderJ,etal.AnalBiochem,1991,192(1):23710TortoN,ButtlerT,GortonL,etal.AnalChimActa,1995,313(1-2):1511ChenAQ,LunteCE.JChromatogr,1995,691(1-2):2912BobsCE,LinharesMC,KissingerPT.CurrSep,1994,13(1):613DawsonLA,StowJM.JChromatogr,1995,700(1-2):8114SteeleKM,KekesiAK,PungorK,etal.JPharmBiomedAnal,1995,13(2):14915BungayPM,MorrisonPF,DedrickRL.LifeSci,1990,46(2):10516StenkenJA,ToppEM,SouthardMZ,etal.AnalChem,1993,65(17):232417LarssonCI.LifeSci,1991,49:PL7318EisenbergEJ,EickhoffWM.JPharmacolToxicolMethods,1993,30(1):2719MenacherryS,HubertW,JusticeJB,Jr.AnalChem,1992,64(6):57728174(1998)©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.20JacobsonI,SandbergM,HambergerA.JNeurosciMethods,1985,15(3):26321LonnrothP,JannsonPA,SmithU.AmJPhysiol,1987,253:E22822WangYF,WongSL,SawchukRJ.PharmaceuticalRes,1993,10(10):141123PalsmeierRK,LunteCE.CancerBull,1994,46(1):5824ZhaoYP,LiangXZ,LunteCE.AnalChimActa,1995,316:40325GoldsmithJD,KujawaSG,HearRes,1995,83(1-2):8026MatsuyamaR,NakashimaM.BiolPharmBull,1994,17(10):139527FukuharaT,GotohM,KawauchiM.Neurosci(OkayamaJpn),1993,19(2):6528SaundersRC,KolachanaBS.ExpBrainRes,1994,98(11):4429TimoshinAA,TskitishviliOV.Experientia,1994,50(7):66730HashizumeT,NittaY,KasuyaK,etal.DomestAnimEndocrinol,1995,12(4):36331WikstroemG,RonguistG,NilssonS,etal.EurHeartJ,1995,46(3):33932HasegawaM,GotoM.NeurosciBiobehavRev,1994,18(4):53733MckimJM,Jr.,MckimJM.FundamApplToxicol,1993,20(2):19034MuellerM,OstenB,SchmidR.Naunyn-SchmiedebergsArchPharmacol,1995,352(4):43835KanathanR,ShuaibA,GoplenG,etal.JNeurosciMethods,1995,60(1-2):15136OkaharaK,MurakamiT.SkinPharmacol,1995,8(3):11337EisenbergEJ,ConzentinoP,EickhoffWM,etal.JPharmacolToxicolMethods,1993,29(2):9338DaviesMI,LunteCE.DrugMetabDispos,1995,23(10):107239ScottDO,LunteCE.PharmRes,1993,10(3):33540BaranowskeRL,WestenfelderC.AmJPhysiol,1994,267(1,Pt.2):F17441StClaireRL,BrouwerKR.JMicrocolumnSep,1991,3(6):53142BlomquistL,DizdarN,KarlssonM.MelanomaRes,1991,1(1):2343DizdarN,KaagedalB,SmedsS,etal.MelanomaRes,1991,1(1):3344BruhnT,ChristensenT,DiemerN.JNeurosciMethods,1995,59(2):16945AlonsoMJ,BruelisauerA.PharmRes,1995,12(2):29146MontgomeryJ,Ste-MarieL,BoismenuD.FreeRadicalBioMed,1995,19(6):92747GiovanniA,SonsallaPK.MonitMolNeurosci.In:RollemaH,WesterinkBHC,DrijfhoutWJ,eds.ProcIntConfinvivomethod,5th.Groningen,Neth:UnivCentPharm,1991.40048KanjiY,YoshitoI.ForensicSciInt,1993,60(3):18349CohenWR,DeutschJ.BioAmines,1994,10(4):34550FuchiT,RosdahlH,HicknerRC,etal.ActaPhysiolScand,1994,151(2):24951LinharesMC,KissingerPT.JPharmBiomedAnal,1993,11(11-12):112152LambertPD,WildingJPH,TurtonMD,etal.BrainRes,1994,656(1):13553deLangeECM,HesselinkMB.PharmRes,1995,12(1):12954AasmundstadTA,MorlandJ,PaulsenRE.JPharmacolEspTher,1995,275(1):435(:1997-05-16)Microdialysis-aNovel,EffectiveTechniqueforinvivoBiologicalSamplingLiGang,CaoYing,HeXiwen(DepartmentofChemistry,NankaiUniversity,Tianjin300071)AbstractMicrodialysisisanovel,effectivetechniqueforinvivobiologicalsampling,involvingmanydisciplines.Ithasmanyadvantagesascomparedwithconventionalbiologicalsamplingmeth238174(1998)©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.ods.Inthisreviewarticle,theprincipleandapplicationofmicrodialysisarediscribed,itscharac2teristicsarediscussed,anditsdevelopmenttrendisdelineated.KeywordsMicrodialysis,Samplinginvivo,Review(1982)174:(:100510070;:87759776):::::::(399):CN44-1318/TH:010029FENXICESHIXUEBAOJournalofInstrumentalAnalysis(Bimonthly,Establishedin1982)Vol.17No.4Jul.251998SponsoredbyChinaAssociationforInstrumentalAnalysis.AssistedbyChineseNationalAnalysisCentre,Guangzhou.Editor-in-chiefChengZhiqing.Edited&PublishedbyEditorialofficeofFENXICESHIXUEBAO(100XianglieZhongRoad,Guangzhou,510070,PRC).Dis