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22220074(300072),,1,,,206070,,,525[1]J.M.Lehn::,,[2]G.H.Pollack,,[3]3,206070;2080,(PLA)(PGA)(PLGA),,,,,,(ECMs),ECMs;ECMsECMs(GAGs)3,((MSCs)),/,,;,;,,,,1,,,,[4]:(1),;(2);(3),/////2//21.1,,,ECMs,((BMPs))DNA,Goldstein[5](PTH)DNA,,DNA,BMPPTH6,,,1.2,(ECMs)ECMs,,ECMs,,[6],(),,,,[7]1.3,ECMs,,,,()[8]M.P.Lutoif[9](integrin)(MMP)MMP(BMP),1.4,()(2D),2(SAM)ECMs(),ECMs,,(CP)(DNP)D.L.Kaplan[10]DNP3050nm,,1.53D2D,[11];,,,,11/m(3DP)HAV5.2V12250,,,,,[12,13](SLS)PVA2HAPEEK2HA,PCL500500,,,[14,15][16](FDM)PCL,PP2TCP,PCL2HA,250,,[17,18](LDM)PCL2PLLA400,[19](SLT)PMA2HAHA,PCL450286394,,,[20][21,22]:HA:;PVA:;PCL:;PP:;TCP:;PLLA:;PMA:2,,,,,,,,[1]2.13,,;()[23],,,,,[24],,,2.2,(ECMs)ECMs,,,ECMs()ECMs[25](22(RGD)),,,RGD,;RGD,,,,,,,[26]2.3,(g),,DNA,,(ng),,,,DNA,2.4DNA,pH,,,[24][27](PIPAAm)(TCPS),,42.5,,,,,(),,[28,29]31998,,9,()(2)[30]21234512345(a)EE(b)EE(c)EE(d)EE(e)EE(f)EE(g)EE:a.,;b.;c.;d.;e.;f.;g.,,MITR.Langer,MichiginD.J.Nooney,RiceA.Mikos,A.HoffmanR.D.Ratner,,,,,,2003,Biomaterials,E.Khor[31],91,10,,,,,5,,,,,,;,,4,,()()(),1,..:,20032LehnJM.NatlAcadSciUSA,2002,99:47633PollackGH.AdvColloidInterfaceSci,2003,107:1734GriffithLG,NavghtonG.Science,2002,95:10095ServiceRF.Science,2000,289:14986MrksichM.ChemSocRer,2002,29:2677RatnerRD.PolymPrep,2003,44:1608LeeKY,MooneyDJ.Chem.Rev,2001,101:18699LutolfMP,LaverJL,FieldsHG,etal.ProcNatlAcadSciUSA,2003,100:541310WilsonDL,MartinR,HmgS,etal.ProcNatlAcadSciUSA,2001,98:1366011CukiermanWE,PankovR,StevensDR,etal.Science,2001,294:170812SeitzH,RiederW,IrsenS,etal.JBiomedMaterResPartB:ApplBiomaterB,2005,74:78213LamCXF,MoXM,TechSH,etal.MaterSciEngC,2002,20:4914ChuaCK,LeongKF,TanKH,etal.JMaterSciMaterMed,2004,15:111315WilliamsJM,AdewunmiA,SchekRM,etal.Biomaterials,2005,26:481716TanKH,ChuaCK,LeongKF,etal.Biomaterials,2003,24:311517ZeinI,HutmacherDW,KimCT,etal.Biomaterials,2002,23:116918EndresM,HutmacherDW,SalgadoAJ,etal.TissueEng,2003,9:68919ZhaoX,YanY,WangSG,etal.ScriptaMaterialia,2002,46:77120WoeseA,RumplerM,StamplJ,etal.MaterSciEngC,2005,25:18121WilsonCE,deBruijnJD,vanBlitterswijkCA,etal.JBiomedMaterRes,2004,68:12322CookeMN,FisherJP,DeanD,etal.JBiomedMaterResPartB:ApplBiomaterB,2002,64:6523RosenCJ.ScientificAmerican,2003,288:7124,.,2001,50:10625KimBS,MooneyDJ.TrendsinBiotech,1998,16:22426StendahlJC,ChenXJ,NieceKL,etal.PolymPrep,2003,44:63427ShimizuT,YamatoM,KikvchA,etal.Biomaterial,2003,24:230928CurtisA,WilkinsonC.TrendsinBiotech,2001,19:9729RouhiAM.ChemEngNews,1999,77:5130GalaerLY,MattiasonB.TrendsinBiotech,1999,17:33531KhorE,LeeYL.Biomaterials,2003,24:23396
本文标题:组织工程用生物材料
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