种方案治疗幽门螺杆菌感染的成本

20071820ChinaPharmacy2007Vol118No1201531*::023-68774633E-mail:liuthcq@sohu1com3-1*,2(11,400037;21,400037)R956;R975+16C1001-0408(2007)20-1531-02:3-:2863,(A),(B),(C),7d,-3:ABC89180%87137%88117%(P0105),5511622310285154d-1:A;;-(Hp),Hp,Hp3-,,11112005120074,Hp286,3:A98,57,41,2366a,(45182216)a;B95,56,39,2369a,(46132312)a;C93,49,44,2465a,(45162213)a3(P0105),112A:(),250mg-1,220mg-1,500mg-1,2d-1,7d;B:(,)20mg500mg400mg,2d-1,7d;C:(,)350mg500mg400mg,2d-1,7d113[14C][1]:2h,0175Ci14C,25min,,415mL,([14C]-UBT):100dpmmmol-1,;100dpmmmol-1,114,;,,0;,,3194,(20mg)14184,(350mg)5102,(500mg)0193,(200mg)0108:A=319427=55116d-1;B=3DrugTreatmentPlansforHelicobacterPyloriInfection:Cost-EffectivenessAnalysisLIUTonghua(Dept1ofPharmacy,XinqiaoHospital,TheThirdMilitaryMedicalUniversity,Chongqing400037,China)ZHANGPengbin(Dept1ofGastroenterology,XinqiaoHospital,TheThirdMilitaryMedicalUniversity,Chon-gqing400037,China)ABSTRACTOBJECTIVE:Tocomparethecost-effectivenessamong3therapiesinthetreatmentofhelicobacterpyloriin2jection1METHODS:Atotalof286patientswithpepticulcerinducedbyhelicobacterpyloriinjectionweredividedinto3groups:GroupAwasassignedtoreceiveLizhuweisanlian,GroupBtoreceiveomeprazoletabletsplusamoxicillincapsulesandmetronidazoietablets,andGroupCtoreceiveranitidinebismuthcitratecapsulesplusamoxicillincapsulesandmetronidazoietablets1Thecourseoftreatmentforallthe3groupswas7consecutivedays1Theoutcomeswereevaluatedbycost-effectivenessanalysismethod1RESULTS:TheresponseratesforGroupA,BandCwere89180%,87137%and88117%,respectively,show2ingnosignificantdifferencesamongthe3groups(P0105);andthedailycostsforthe3groupswere55116yuan,223102yuan,and85154yuan,respectively1CONCLUSION:IntermsofpharmacoeconomicsPlanAisthemosteconomicalone1KEYWORDSHelicobacterpyloriinjection;Drugtreatmentplans;Cost-effectivenessanalysis1532ChinaPharmacy2007Vol118No120200718202007630,2007,,,,,,,,GeoffreyA1Donnan(14184+0193+01082)27=223102d-1;C=(5102+0193+01082)27=85154d-11153,--;3,,1162,P010522117d,3113Tab1Comparisonofcurativeeffectsamong3groups/%A98881089180B95831287137C93821188117AB,2=010024(P0105),;BC,2=010025(P0105),,3212-3,,,,A,B,C,A3Hp,94%84%Hp[2],Hp,Hp,1996:(1)Hp90%;(2)5%;(3)1wk;(4)[3](PPI)22[4]3,2,1wk,24,Hp,[5]A,3,;,-,,;,,Hp[6]BPPIPPI,Hp,Hp(ATP),,,PPI,[7],HpHp,,,E,Hp,,[8]CB,,,,Hp,PPI[9],PPI1/4[1],,13[J]1,2005,21(13):13961[2],1[J]1,2002,15(6):3251[3],1[J]1,2003,24(22):521[4],1[J]1,2005,18(5):3651[5],,12[J]1,2002,2(6):8701[6],,1[J]1,2004,28(8):6441[7],1[J]1,2005,26(10):10701[8]1-[J]1,2005,16(1):361[9],,1[J]1,2005,20(6):5681(:2006-11-30:2007-05-16)2007