超临界流体萃取技术及其在中药提取中的应用

1,2(11,300131;21,300193):,,,,:;;;;;:R28412:A:16745515(2009)0520279204,,,,,(SFE),,1SFE3,,,3,,,[1]SFE,,,,100,,,,[122]2(SCF)(Tc)(Pc),,,CO2N2NOCH4CHF1[2]1(25)/(kJmol-1)/Tc/Pc/MPadc/(gcm-3)25125-7815311371150144823127-331413213111270124035132641724015811001272381957814243146120012764010682152351541600127315110-441596184112012202215001051521031680122827129361319616312701232331123910234102190012342,32271295810226183104012413319080112281941890130226102341619316315601267SCF,,,,,3311,,SCF,;,SCF,,,312,,SCF,313,,SCF972ModernPharmacyandClinic2009245,;,,,,314SCF,,;,,,,SCF[3]315,,,,,,[4]:,,;SCF,,SFE,SFE,,[526],,SFE,4SFE411,,SFE,[7]SFE,,CO2(CO22SFE),2,22[8]CO2,GC2MS,36[9]CO22SFECO22SFE,,,,,3SFE[10][11]CO22SFE113197%,214,78157%,CO2412,CO2[12]2SFE,SFE,,1h,8913%,28012%,6416%,5512%,[13]SFE,713%,,HPLC[14]118212,92%,CO2CO22SFE,10[15]Kevin[16],CO22SFECO2413,,,,[17]SFE,60,42MPa,4min,4mL,012mL414,,082ModernPharmacyandClinic2009245,SFE,,,[18],A20%,35%,2(SAS),26MPa,38,015MPa/min,70%[19]SFE,,A,[20][21],CO22SFE,415CO22SFE,;,,CO22SFE,,[22]CO22SFE,GC2MS15416,CO22SFE,CO21196%,(0102%)(1116%),[23][24]CO2,[25]CO2,,5,,GCIRMSSFE,,,,SFE,,,[1]1[M]1:,20051[2],,1[M]1:,20021[3],,,1[J]1,2007,26(8):48724881[4],,1[J]1,2000,6(1):162201[5]JohnstonKP,HarrisonKL,ClarkeMJ,etal1Water2in2carbondioxidemicroemulsions:Anenvironmentforhydro2philesincludingproteins[J]1Science,1996,271:6241[6]TenaMT,CastroMDL,ValcarcelM1Improvedsuper2cri2ticalfluidextractionofsulphonamides[J]1Chromatograph2ia,1995,40(3/4):19722011[7],,.CO2[J]1,2007,18(33):2584225851[8],,.CO2[J]1,2007,18(36):2841228431[9],,,1CO2[J]1,2005,27(8):88528871[10],,,1[J]1,2003,28(6):57225741[11],1CO2[J]1,2007,35(9):752781[12],1[J]1,2002,27(8):58525861[13],,,1[J]1,2000,31(3):19922011[14],,,1[J]1,2003,26(6):42624271[15],,1CO2[J]1,2001,24(6):4151[16]KevinLK,JohnJJ1Supercriticalfluidextractionofstrych2182ModernPharmacyandClinic2009245nineusingtwodifferentsequentialorganicmodifiers[J]1JAgricFoodChem,1995,43(5):1208212111[17],,,12[J]1,2000,21(10):95829601[18],,1CO2[J]1,2001,20(5):71[19],1CO2A[J]1,2006,21(1):192201[20],,,1CO2[J]1,2003,28(5):41324171[21],,,12HPLC[J]1,1999,30(4):2581[22],1GC2MS[J]1,2004,29(3):21422441[23],1CO2[J]1,2006,29(4):33923401[24],,1CO2[J]1,2004,24(4):4621[25],,,1CO2[J]1,2002,31(3):1811(2009204203)1,2(11,300070;21,300111):,3,,,:;;;;:R94419:A:16745515(2009)0520282204(transdermaldrugdeliverysys2tems,TDDS),TDDS(patch),TDDS,TDDS,,1TDDSTDDS,:,;,,;,,;,,;,,,,,,1981Alza,TDDS,,,1112%,200067,200391,201080010002,,,,211,282ModernPharmacyandClinic2009245