DNA复制(DNA-Replication)英文版

静思笃行持中秉正•WuhanUniversity•TheCollegeofLifeScience***大学***大学●DNAreplicationisaprocessinwhichtwosamecopiescanbeobtained.●DNAreplicationissemi-conservative,onestrandservesasthetemplateforthesecondstrand.●Furthermore,DNAreplicationonlyoccursataspecificstepinthecellcycle.***大学●Template:OneofthestrandofdsDNA;●dNTPs:4kinbsofdeoxynucleotidetriphosphates,that's,ATP,GTP,CTP,TTP;●Primer:usuallyRNA;●Proteinsandenzyme:suchasDNApolymerase,DNAhelicase,SinglestrandDNAbindingprotein（SSB）,DNAtopoisomerase,DNAligase,Telomerase(specialineuka-ryotes);***大学***大学***大学***大学***大学●DNApolymerase;●DNAhelicase;●SinglestrandDNAbindingprotein（SSB）;●DNAtopoisomerase;●DNAligase;●Initiator;***大学***大学***大学●InE.coli，DnaAbonds9bpreverserepeatsequences,anddegenerates13bpsequences.Thenopeninitiationcomplexisformed.●IntheconditionthatATPofferenergy,13bpareunlinked.AtthattimeallssDNAarecoveredbySSB.●DnaBunlinksdsDNAtemplateinreplicationfork.Primasecatalysizestosynthetizeprimers.●CoreIaddsdNTPto3'-OHonleadingchaintemplateandcontinuestosynthetzeleadingchain***大学***大学***大学***大学***大学***大学***大学***大学***大学***大学