超声促渗技术的研究进展

:,400038:,,,,.:R312:A:1672-7290(2004)01-0038-03,,2060,,40,,,1,,():;;(),,2060,,(13MHz),,,(ultrasonicener2gy)[1],(13MHz12W/cm2,510min,),2080,,,,[2],,201995,,,[3],(20100kHz),Tachibana[4]148kHz5min,80%Tezel[5],(20kHz),(),20kHz100[6][7],,,,,2,,2.1,,,,Asano[8](1MHz,12W/cm2,),1W/cm26;2W/cm211,;,,,,[9],(13MHz)138781KD(D-),[10]2.2,,;,,(),(,,,,)Rrm,RrF(kHz):FRr=3000,1MHz3m,20kHz150m,,,,,,,,,,,[11](1.1MHz,1.5W/cm2)13mm,83ChineseJournalofPracticalAestheticandPlasticSurgery,2004.Vol.15No.1©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.(1MHz,4.3W/cm2)515mm(pit)20kHz[12],,,100150m[13],20kHz,,,[14],,,,,,5m,(waterway),,[15],,[16]2.3,,[14],2.4,,[17][18]3,,,,,3.1,[19](612),,,,(collitinelastalitin),3.2-E[20],4.4,30%Ivashchuk[21],,3.3,[22]3.42080,,3.5,,[11],[23][4]44.123W/cm2,(13MHz),,[13],,4.2Gogstetter[24],,,,4.3,()4.4,[15]5,,(),,,,,[25],1BommannanD,OkuyamaH,StaufferP,etal.Sonophoresis.I.Theuseofhigh-frequencyultrasoundtoenhancetransdermaldrugdelivery[J].PharmRes,1992,9(4):559.2MeidanVM,WalmsleyAD,DockerMF,etal.Ultrasound-en2hanceddiffusionintocouplinggelduringphonophoresisof5-fluo2rouracil[J].IntJPharm,1999,185(2):205.3MitragotriS,BlankschteinD,LangerR.Amechanisticstudyoful2trasonically-enhancedtransdermaldrugdelivery[J].JPharm.Sci,1995,84(6):697.4TachibanaK.Transdermaldeliveryofinsulintoalloxan-diabetic9320042151©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.rabbitsbyultrasoundexposure[J].PharmRes,1992,9(7):952.5TezelA,SensA,TuchschererJ,etal.Frequencydependenceofsonophoresis[J].PharmRes,2001,18(12):1694.6KostJ,MitragotriS,GabbayR,etal.Transdermalmonitoringofglucoseandotheranalytesusingultrasound[J].NatureMed,2000,6(3):347.7MitragotriS,KostJ.Transdermaldeliveryofheparinandlow-molecularweightheparinusinglowfrequencyultrasound[J].PharmRes,2001,18(8):1151.8AsanoJ,SuishaF,TakadaM,etal.Effectofpulsedoutputultra2soundonthetransdermalabsorptionofindomethacinfromanoint2mentinrats[J].BiolPharmBull,1997,20(3):288.9MerinoG,KaliaYN,Delgado-CharroMB,etal.Frequencyandthermaleffectsontheenhancementoftransdermaltransportbysonophoresis[J].JControlRelease,2003,88(1):85.10VesnaZderic,ShahramVaezy,RoyW,etal.Oculardrugdeliveryusing20-kHzultrasound[J].UltrasoundinMedicine&Biology,2002,28(6):823.11PoliachikSL,ChandlerWL,Mourad,etal.Activation,aggrega2tionandadhesionofplateletsexposedtohigh-intensityfocusedul2trasound[J].UltrasoundMedBiol,2001,27(11):1567.12TeraharaT,MitragotriS,KostJ,etal.Dependanceoflow-fre2quencysonophoresisonultrasoundparameters,distanceofthehornandintensity[J].IntJPharm,2002,235(1-2):35.13YamashitaN,TachibanaK,OgawaK,etal.Scanningelectronmicroscopicevaluationoftheskinsurfaceafterultrasoundexposure[J].AnatRec,1997,247(4):455.14FrenkelV,KimmelE,IgerY,etal.Ultrasound-inducedinter2cellularspacewideninginfishepidermis[J].UltrasoundMedBiol,2000,26(3):473.15FunkeAP,GuntherC,MullerRH,etal.In-vitroreleaseandtransdermalfluxesofahighlylipophilicdrugandofenhancersfrommatrixTDS[J].JControlRelease,2002,82(1):63.16TangH,WangCC,BlankschteinD,etal.Aninvestigationoftheroleofcavitationinlow-frequencyultrasound-mediatedtransder2maldrugtransport[J].PharmRes,2002,19(8):1160.17MitragotriS,FarrellJ,TangH,etal.Determinationofthresholdenergydoseforultrasound-inducedtransdermaldrugtransport[J].JControlRelease,2000,63(1-2):41.18TachibanaK,TachibanaS.Theuseofultrasoundfordrugdelivery[J].Echocardiography,2001,18(4):323.19GerasimenkoMIu,ZengerVG,IusovaZhIu.Differentialapproachtotheuseofdrugultraphonophoresisforscars[J].VoprKurortolFizioterLechFizKult,2002,Mar-Apr(2):36.20LobanovskiiGI,LevitskiiAP,SavkoNV.Clinicaluseofcatomasandbiotritinacombinedtreatmentofpatientswithchronicneuro2dermatitis[J].LikSprava,2001,(2):116.21IvashchukSI.Theinfluenceoftheintra-tissueelectricalphonophoresisonthehemostasissysteminthetreatmentofacutethrombophlebitisandphlebothrombosis[J].KlinKhir,1999,Jan(5):19.22BaskurtF,OzcanA,AlgunC.Comparisonofeffectsofphonophoresisandiontophoresisofnaproxeninthetreatmentoflat2eralepicondylitis[J].ClinRehabil,2003,17(1):96.23HuberPE,DebusJ.Tumorcytotoxicityinvivoandradicalforma2tioninvitrodependontheshockwave-inducedcavitationdose[J].RadiatRes,2001,156(3):301.24GogstetterDS,GoldsmithLA.Treatmentofcutaneoussarcoidosisusingphonophoresis[J].JAmAcadDermatol,1999,40(5Pt1):767.25BarryBW.Novelmechanismsanddevicestoenablesuccessfultransdermaldrugdelivery[J].EurJPharmSci,2001,14(2):101.(:2003-06-15):,200011;:,,,,.:R318:A:1672-7290(2004)01-0040-04,,,,,[1]:;[2,3],,1206070,,[4],,,[5],(3H-TdR)(BrdU),,,04ChineseJournalofPracticalAestheticandPlasticSurgery,2004.Vol.15No.1©1995-2006TsinghuaTongfangOpticalDiscCo.,Ltd.Allrightsreserved.