NQO1与肿瘤

NUP98FGNSD1NSD3PHDPWWPSAC/SET,(CREB),,NUP98-NSD[15,16]NUP98,NUP98FGDDX10DEADTOP1LINKLEDGFHMG-1RAP1GDS1ARMADILLO,,,NUP98FG,NUP98mRNA[6],,NUP98[24][1]RabbittsTH.Nature,1994,372:143-149.[2]LookAT.Science,1997,278:1059-1064.[3]RowleyJD.AnnuRevGenet,1998,32:495-519.[4]RaduAetal.Cell,1995,81:215-222.[5]MaconochieMetal.AnnuRevGenet,1996,30:529-556.[6]LamDH,AplanPD.Leukemia,2001,15:1689-1695.[7]NakamuraTetal.NatGenet,1996,12:154-158.[8]BorrowJetal.NatGenet,1996,12:159-167.[9]Raza-EgilmezSZetal.CancerRes,1998,58:4269-4273.[10]TaketaniTetal.CancerRes,2002,62:4571-4574.[11]FujinoTetal.Blood,2002,99:1428-1433.[12]SuzukiAetal.BrJHaematol,2002,116:170-172.[13]TaketaniTetal.CancerRes,2002,62:33-37.[14]NakamuraTetal.Blood,1999,94:741-747.[15]JajuRJetal.Blood,2001,98:1264-1267[16]RosatiRetal.Blood,2002,99:3857-3860.[17]AraiYetal.Blood,1997,89:3936-3944.[18]AhujaHGetal.Blood,1999,94:3258-3261.[19]HusseyDJetal.Blood,1999,94:2072-2079.[20]AhujaHGetal.CancerRes,2000,60:6227-6229.[21]KasperLHetal.MolCellBiol,1999,19:764-776.[22]LawrenceHJetal.StemCell,1996,14:281-291.[23]ThorsteinsdottirUetal.HematolOncolClinNorthAm,1997,11:1221-1237.[24]NishiyamaMetal.GenesChromosomesCancer,1999,26:215-220.NQO1代恩勇综述　卢振霞审校(吉林大学中日联谊医院血液肿瘤科,吉林长春130031):NQO1,NQO1,,p53TNF-a,cDNA609C/T,,,NQO1:NQO1;化学保护;生物激活;基因多态性;肿瘤:R730:A:1001-1048(2003)03-0141-04:2002-11-13:(1977-),,/:[NQO1,NADPH:quinoneoxido-reductase,EC.1.6.99.2],D-(DT-diaphorase)[1],,NAD(P)H,,2,,,NQO1,NQO116p22[2],cDNA609C/T[3],,Hardy-Weinberg187/,,2,18,,[4],hsp70[5],1412003263,3[6],()[7,8],,22.4%,50%1NQO11.1　NQO1与醌类化合物的致癌作用NQO1,,,(VEVK),NQO1,DNA,,NQO1Wt/Wt*Wt/VV/VWt:V(n=114)64(56.1%)45(39.5%)5(4.4%)0.75:0.25(n=161)52(32.3%)84(52.5%)25(15.5%)0.57:0.43(n=136)83(61.0%)46(33.8%)7(5.2%)0.78:0.22(n=69)23(33.3%)33(47.8%)13(18.8%)0.58:0.42(n=49)14(28.8%)24(50.0%)11(22.4%)053:0.47:*Wt;VNQO1,CHO,NQO1CHO[9],LongNQO1C57BL/6,DMBA(7,12climethyl-benz(a)anthrance),23NQO1(100%VS33%P0.01,8mmVS2mm),40%[10],benzo(a)pyrene[11],NQO1VK3,[12],NQO1,NQO1,7,,NQO1[13]1.2　NQO1与化学抑癌剂的防癌作用,,NQO1,,,H2O2Bap[benzo(a)-pyrene]DNA[14];(quercetin),[15],MCF-7,NQO1mRNA,NQO1[16],NQO11.3　NQO1对p53稳定性调节与肿瘤发生p53,p53,NQO1p53,CM1NQO1NAD+p53[17],NQO1p53,,p53[18],,,NQO1p53,NQO12NQO11422003263NQO1,NQO12.1　NQO1与含醌烷化剂激活(MitomycinC,MMC),,WillsonNQO1HCT-116-R30AMMC[19],NQO1BEMMC,NQO1cDNABEMMC,MMC[20];MMCNQO1NQO1[21]NQO1cDNABENQO1[22]EO9RH1,NQO1,NQO1,EO9,,,PH[23]RH1NQO1BE-NQ7MMC5[22],RH1EO910,,EO9,NQO1,,NQO1,[24]NQO1,[25]2.2　NQO1与细胞凋亡B-lapachone,[26],NQO1NQO1,B-lapachone,NQO1[27]NQO1B-lapachone,/,,B-lapachoneB-lapachone-A(tumornecrosisfactor-A,TNF-A),,TNF-A,TNF-A[28],NQO1MCF-7TNF-A,NQO1,TNF-A[29]3NQO1NQO1C609TNQO1,,NQO1,NQO1NQO1,k-rasNQO120%,6[30]NQO1[31],,NQO14[32]NQO1NQO1[33],NQO1NQO1[34,35]NQO1NQO1[36]NQO1,NQO1[37],NQO1,CD34+[38],,,NQO1[39],NQO1,,C609T,;1432003263;[1]EmsterLetal.BiophysActa,1962,58:171-175.[2]RosvoldEAetal.Pharmacogenetics,1995,5(4):199-206.[3]TraverRDetal.BrJCancer,1997,75(1):69-75.[4]SiegelDetal.MolPharmacol,2001,59(2):263-268.[5]AnwarAetal.JBiolChem,2002,30:14060-14067.[6]KuehlBLetal.BrJCancer,1995,72(3):555-561.[7]GaedigkAetal.Pharmacogenetics,1998,8(4):305-313.[8]KelseyKTetal.BrJCancer,1997,76(7):852-854.[9]JosephPetal.BiochemPharmacol,2000,60(2):207-214.[10]LongDJ2ndetal.JNatlCancerInst,2001,93(15):1166-1170.[11]LongDJ2ndetal.CancerRes,2000,60(21):5913-5915.[12]RadjendiraneVetal.JBioChem,1998,273(13):7382-7389.[13]NebertDWetal.GenetMed,2002,4(2):62-70.[14]BonnesenCetal.CancerRes,2001,61(16):6120-6130.[15]BalasubramanianS,GovindasamyS.Carcinogenesis,1996,17(4):877-879.[16]JosephPetal.BiochemPharmacol,2000,60(2):207-214.[17]AsherGetal.ProcNatlAcadSciUSA,2001,98(3):1188-1193.[18]AsherGetal.NatlAcadSciUSA,2002,99(5):3099-3104.[19]WillsonJKetal.CancerRes,1984,44(12Pt1):5880-5885.[20]TraverRDetal.CancerRes,1992,52(4):797-802.[21]FlemingRAetal.Pharmacogenetics,2002,12(1):31-37.[22]WinskiSLetal.ClinCancerRes,1998,4(12):3083-3088.[23]ChoudryGAetal.BrJCancer,2001,85(8):1137-1146.[24]SiegelD,RossD.FreeRadicalBiologyandMedicine,2000,29(3-4):246-253.[25]WinskiSLetal.CancerRes,2002,62(5):1420-1424.[26]PlanchonSMetal.ExpCellRes,2001,267(1):95-106.[27]PinkJJetal.JBiolChem,2000,275(8):5416-5424.[28]ZimmermanRJetal.CancerRes,1989,49(7):1644-1648.[29]ZimmermanRJetal.CancerRes,2000,60(13):3638-3644.[30]LafuenteMJetal.Carcinogenesis,2000,21(10):1813-1819.[31]HarthVetal.ArchToxicol,2000,73(10-11):528-531.[32]LewisSJetal.LungCancer,2001,34(2):177-183.[33]RosvoldEAetal.Pharmacogenetics,1995,5(4):199-206.[34]SmithMTetal.Blood,2001,97(5):1422-1426.[35]LarsonRAetal.Blood,1999,94(2):803-807.[36]SmartRC,ZannoniVG.MolPharmacol,1984,26(1):105-111.[37]SiegelDetal.ToxicolLett,2001,125(1-3):93-98.[38]MoranJLetal.ProcNatlAcadSciUSA,1999,96(14):8150-8155.[39]SmithMT.EnvironHealthPerspect,1996,104Suppl6:1219-1225.何红媛　夏　冬综述　吴绍华审校(四川省泸州医学院,四川泸州646000):,:精原干细胞;生物学特性;实验研究;移植:R329.2+3:A:1001-1048(2003)03-0144-04:2002-11-21:(1974-),,(spermatogonialstemcells),,[1],1As(Asingle)[2],,Apr(Apaired)(1)[3]Apr,4816Aal(Aaligned)As12()(2)[3]1442003263