CST公司信号通路图Growth-&-Differ

HistoneH3CREBSRFPPARγERElk-1Stat1/3c-Myc/N-MycMSK1/2p90RSKp90RSKp90RSKErk1/2Erk1/2Erk1/2MNK1/2cPLA2nNosMEK1/2PP1/PP2AtB-RafB-RafPKAc-Rafc-RafPKCPLCγSrcPYK2PAKSprySpredTpl2/Cot1PI3KPaxFAKFynGRB2GRB2RasRacRap1CRK14-3-3IntegrinsMEK1MP1Erk1P14C-TAK1IMPRACK1ATF1c-FosEtsPax6UBFMKP-1/2cdc25MKP-3KSR1/2c-FosFox03ERαATF4MITFMad1Nur77ETV1TIF1AeIF4BMETTL1eEF2KGSK-3rpS6TCPβIκBαBADDAPKC/EBPβMyt1BUB1FilaminAER81HMGN1RanBP3TIF1Ap27KIP1TSC2PEA-15BimTalShcFRS2IRSSOSSOSSOSEPACIonChannels[Ca2+]RTKsRTKsC3GCAS[cAMP][Ca2+]TranslationControlIonChannels,ReceptorsNucleusCytoplasmHeterodimerBID-1870TranscriptionPD98059U0126LateEndosomeCellAdhesionCytoplasmicAnchoringMAPK/ErkinGrowthandDifferentiation©2003–2010CellSignalingTechnology,Inc.MAPK/ErkinGrowthandDifferentiation•createdJanuary2003•revisedNovember2010DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKey©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase