蓝光的医学应用研究进展-王宁

JOUＲNALOFSHANGHAIJIAOTONGUNIVEＲSITYMEDICALSCIENCE|Vol．34No．10Oct．20141988—[e-mail]。[e-mail]。201999、、、、、、、。。。。DOI10．3969/j．issn．1674-8115．2014．10．028Ｒ454．2AAdvancesofapplicationofbluelightinmedicineWANGNing，YAOMin，FANGYongDepartmentofBurnandPlasticSurgery，theThirdPeople'sHospital，ShanghaiJiaoTongUniversitySchoolofMedicine，Shanghai201999，China［Abstract］ThebluelightcansuccessfullyinactivatevariousGram-positivebacteria(S．aureus，Staphylococcusepidermidis，Enterococcusfaecalis，andClostridiumperfringens)andGram-negativebacteria(A．baumannii，P．aeruginosa，Escherichiacoli，Proteusvulgaris，andKlebsiellapneumonia)andiswidelyusedfortheclinicaltreatmentofneonataljaundiceandacne．Ｒecentlyresearchersfoundthatthebluelightisalsoeffectiveforthetreatmentofatopicdermatitisandpsoriasisvulgaris．Thispaperreviewstheliteraturepublishedinrecentyearsfromhomeandabroad，introducesresearchprogressesofthebluelightinbasicmedicineandclinicalmedicine，andprovidesreferencesforcliniciansandscientificresearchers．［Keywords］bluelight;antibacterialeffect;photodynamictherapy350～455nm、455～492nm、492～577nm、577～597nm、597～622nm622～770nm。。。50“”1。。23、4。5。、67。405～470nm8。。·4551·|20143410．1。Kawada9407～420nm25cm324J/cm21h15.7%24.4%。Ashkenazi1010cm75J/cm22～3。Hamblin11405nm7ATCC70082420J/cm299．9%。Fukui12400～700nm400nm410nm430nm。1314。Enwemeka15405nm470nm50～55J/cm290%。Guffey16。Maclean17405nm、、、、、、、405nm。。Fan18420nm6α-2。5415nm。21119。pH20。21。AT17978A22。23。、。3246mm1～2mm25。Bache26405nm。Becker27。Liebmann28453nm＜500J/cm2。Weinstabl29420nm453nm。。20%·5551·JOUＲNALOFSHANGHAIJIAOTONGUNIVEＲSITYMEDICALSCIENCE|Vol．34No．10Oct．2014．30。Ganz31405nm“”。。DNA。4①。②。③。④32。33。Kleinpenning34。35。TCD4+、CD8+、CD4+/CD8+、CD35+CD3+。。。、。1NordmannPPoirelLTolemanMAetal．Doesbroad-spectrumbeta-lactamresistanceduetoNDM-1heraldtheendoftheantibioticerafortreatmentofinfectionscausedbyGram-negativebacteriaJ．JAntimicrobChemother2011664689－692．2DaiTHuangYYHamblinMＲ．Photodynamictherapyforlocalizedinfections－stateoftheartJ．PhotodiagnosisPhotodynT-her200963－4170－188．3DaiTTegosGPZhiyentayevTetal．Photodynamictherapyformethicillin-resistantStaphylococcusaureusinfectioninamouseskinabrasionmodelJ．LasersSurgMed201042138－44．4DemidovaTNGadFZahraTetal．Monitoringphotodynamictherapyoflocalizedinfectionsbybioluminescenceimagingofgeneti-callyengineeredbacteriaJ．JPhotochemPhotobiolB200581115－25．5DaiTVrahasMSMurrayCKetal．UltravioletCirradiationanalternativeantimicrobialapproachtolocalizedinfectionsJ．ExpertＲevAntiInfectTher2012102185－195．6ZhangYSongSFongCCetal．cDNAmicroarrayanalysisofgeneexpressionprofilesinhumanfibroblastcellsirradiatedwithredlightJ．JInvestDermatol20031205849－857．7HawkinsDHoureldNAbrahamseH．LowlevellasertherapyLLLTasaneffectivetherapeuticmodalityfordelayedwoundhealingJ．AnnNYAcadSci20051056486－493．8DaiTGuptaAMurrayCKetal．Bluelightforinfectiousdisea-sesPropionibacteriumacnesHelicobacterpyloriandbeyondJ．DrugＲesistUpdat2012154223－236．9KawadaAAraganeYKameyamaHetal．Acnephototherapywithahigh-intensityenhancednarrow-bandbluelightsourceanopenstudyandinvitroinvestigationJ．JDermatolSci2002302129－135．10AshkenaziHMalikZHarthYetal．EradicationofPropionibac-teriumacnesbyitsendogenicporphyrinsafterilluminationwithhighintensitybluelightJ．FEMSImmunolMedMicrobiol200335117－24．11HamblinMＲViveirosJYangCetal．Helicobacterpyloriaccu-mulatesphotoactiveporphyrinsandiskilledbyvisiblelightJ．AntimicrobAgentsChemother20054972822－2827．12FukuiMYoshiokaMSatomuraKetal．Specific-wavelengthvisi-blelightirradiationinhibitsbacterialgrowthofPorphyromonasgingi-valisJ．JPeriodontalＲes2008432174－178．13FeuersteinOPersmanNWeissEI．PhototoxiceffectofvisiblelightonPorphyromonasgingivalisandFusobacteriumnucleatumaninvitrostudyJ．PhotochemPhotobiol2004803412－415．14LiangJYYuannJMChengCWetal．BluelightinducedfreeradicalsfromriboflavinonE．coliDNAdamageJ．JPhotochemPhotobiolB201311960－64．15EnwemekaCSWilliamsDEnwemekaSKetal．Blue470-nmlightkillsmethicillin-resistantStaphylococcusaureusMＲSAinvitroJ．PhotomedLaserSurg2009272221－226．1562·6551·JOUＲNALOFSHANGHAIJIAOTONGUNIVEＲSITYMEDICALSCIENCE|Vol．34No．10Oct．2014．－opmentandclinicaltranslationofaPSMA-Targeteddocetaxelnanop-articlewithadifferentiatedpharmacologicalprofileJ．SciTranslMed20124128128ra39．5WangKZhangTLiuLetal．Novelmicelleformulationofcurcu-minforenhancingantitumoractivityandinhibitingcolorectalcancerstemcellsJ．IntJNanomedicine201274487－4497．6ShaikhJAnkolaDDBeniwalVetal．Nanoparticleencapsulationimprovesoralbioavailabilityofcurcuminbyatleast9-foldwhencomparedtocurcuminadministeredwithpiperineasabsorptionenhancerJ．EurJPharmSci2009373－4223－230．7KakkarVSinghSSinglaDetal．Exploringsolidlipidnanoparti-clestoenhancetheoralbioavailabilityofcurcuminJ．MolNutrFoodＲes2011553495－503．8MukerjeeAVishwanathaJK．Formulationcharacterizationandevaluationofcurcumin-loadedPLGAnanospheresforcancertherapyJ．AnticancerＲes200929103867－3875．2014-03-20櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗櫗155616GuffeyJSWilbornJ．Invitrobactericidaleffectsof405-nmand470-nmbluelightJ．PhotomedLaserSurg2