生物材料表面界面特性与其血液相容性的关系

..200368283易树尹光福综述郑昌琼审校=不可否认生物材料表面界面特性是影响其血液相容性的重要因素本文总结了生物材料引发血栓的各条途径以及作用机理,并综述了生物材料表面特性与其血液相容性之间的关系=生物材料;表面界面特性;血液相容性:R318.08:A:1007_3957(2003)08_83_061,,,(),[1],,[2]2[3~7],,,[8~11]1,,[12][13],()[14]:2.1XII,:,[15],:¹,XIIXIIa.XIIa,XII,,XIIa,XIIaXIXIa,.,:610065(39870232)(2000061004)2003682..84,XII:()ºXIa,,,IXVIIIVX,»,,ABC3,,C89A283,ANA-,BNB-,A-B-,,A-B-,,A-B-,,VIIIa,,2.2VIIIVonWiller-rand,,(,(GPIIb-IIIa)),,;[16]GPIIb-IIIa[17~21],,,ADP,ADP,;,24)))3,[22,23]E#Ruckenstein[24]:,,,,,[25],,,,GPIIb-IIIa[20],:,,,,XIIIaCa2+,Barnhart,Courtney[12],2.3,,,))))))ADP,2.420,C1-C99,,..2003682852,[26]:a)[2]7C3,[28],C3,C3C3aC3b,C3b,C3C5C5aC5b,C5bC5ab),,C3b,,C5-C9,3,:2:44.1,,,,,,,,,:,,0.1-0.2Lm4.2,,[29],,,,,C-,,;Fab,Fc,Fc,[30],,,,[31],[32]4.3,,,,XII2003682..86,,,,100,,,,,,[33],,,,,;N,,,[34,35]4.4[36],,,,,,[37,38]NiylasCsdCsp[39],Csp/CsKaeble[40],,,,Ratner[41]:E.Ruckenstein:,,,,5,,,,XII,,,,,,,,,1YangDazhi,LiuJingxiao,WangWeiqiangetal.Pro-ceedingsof98WorkshoponTissueEngineering(Tianjin,China,1998)p.1362FumabashiH,MiyamotoY,lsonoYetal.PreparationandcharacterizationofapentablockcopolymeroftheABACAtype.Macromolecules,1983;16:13FeijenJ.Thrombogenesiscausedbyblood-foreignsu-rfaceinteraction.In:KenediRM,CourtneyJM,GaylorJDS,GilchristI,eds.ArtificialOrgans.London:Macmillan,1977:235~2474BruckSD.PropertiesofBiomaterialsinthePhysiolog-icalEnvironment.BocaRaton,FL:CRCPress,19805AndradeJD,ColemanDL,DidisheimPetal.Blood-materialsinteractions-20yearsoffrustration.TransAm.Soc.Artif.Intern.Organs1981;27:659~662..2003682876SzycherM.Thrombosis,hemostasis,andthrombolysisatprostheticinterfaces.In:SzycherM,ed.BiocompatiblePolymers,MetalsandComposites.Lancaster,PA:Tech-nomic,1983:1~337MurabayashiS,NoseY.Biocompatibility:bioenginee-ringaspects.Artif.Organs1986,10:114~1218HoffmanAS.Modificationofmaterialssurfacetoaffecthowtheyinteractwithblood,Ann.NYAcad.Sci.,1987,516:969BaierRE,LoebGIandWallaceGT.FedProc,1971,30:152310LymanDJandKimSW,etal.TASAIO,1974,20:48011KimSWandLeeES.JPolymSci:PolymerSymp,1979,66:42912CourtneyJM,SundaramS,ForbesCD.Extracorporealcirculation:biocompatibilityofbiomaterials.In:FrobesCD,CushieriA,eds.Managementofbleedingdiso-rdersinsurgicalpratice.Oxford:BlackwellScientific,1993,236~27313BrashJL.Roleofplasmaproteinadsorptionintheresponseofbloodtoforeignsurfaces.In:SharmaCP,SzycherM,eds.BloodCompatibleMaterialsandDevices.Lancaster,PA:Technomic,1991:3~2414ForbesCD,PrenticeCRM.Thrombusformationandartificialsurfaces.BrMedBull1978,34:201~20715BasmadjianD,SeftonMV,BaldwinSA.Coagulationonbiomaterialsinflowingblood:Sometheoreticalconsid_erations.Biomaterials,1997,18(23):151116Chandrap.sharma,MichaelSzycher,BloodCompatibleMaterialsandDevices(TechnomicPublishingCompny,Pennsylvania,U.S.A.,1991)p.13617AndradeJD,HladyV.ProteinAdsorptionandMater-ialsBiocompatibility:ATutorialReviewandSuggestedHypotheses,AdvancedinPolymerScience79,SpringerVerlagBerlinHeidelberg198618PlowEF,MarquerieGA.ParticipationofADPinthebindingoffibrinogentothrombin-stimulatedplatelets.Blood1980,56:553~55519KornechiE,NiewiarowskiS,MorielliTA,KloczewiakM.EffectsofchymotrypsinandadenosinediphosphateontheexposureoffibronegenreceptorsonnormalhumanandGlangmann'sthrombasthenicplatelets.J.Biol.Chem.1981,256:5696~570120DiMinnoG,ThiagarajanP,PerussiaBetal.Expo-sureofplateletfibrinogen-bindingsitesbycollagen,arachidonicacidandADP:inhibitionbyamonoclonalantibodytotheglycoproteinIIb-IIIacomplex.Blood.1983,61:140~14821YoungBR,LambrechtLK,AlbrechtRM,MosherDFetal.Platelet-proteininteractionsatblood-polymerinterfacesinthecaninetestmodel.Trans.Am.SocArtif.Intern.Organs.1983,29:442~44622NeedlemanSW,HookJC.Plateletsandleukocytes.In:ColmanRW,HirshJ,MarderVJ,eds.HemostasisandThrombosis:Basicprinciplesandclinicalpractice.Philadelphia:Lippincott,1982,716~72523WalshPN.Platelet-coagulantproteininteracions.InColmanRW,HirshJ,MarderVJ,eds.HemostasisandThrombosis:Basicprinciplesandclinicalpractice.Philadelphia:Lippincott,1982,404~42024E#RuckensteinandS#V#Gourisankar,J.ColloidInterfaceSci.,1984,101:436~45125PaulL,SharmaCP.Preferentialadsorptionofalbuminontoapolymersurface:anunderstanding,J.ColloidinterfaceSci,1981,84:54626.,,1993,1:138~18127AlfredKCheung,CharlesJParker,LinderWilcoxetal.Activationofthealternativepathwayofcomple-mentbycellulosichemodialysismembranes.KindneyInt,1989,36:25728CliffordJHolmes.Hemodialyzerperformance:biologicalindices.ArtifOrgans,1995,19(11):112629LuDR,ParkK.Effectofsurfacehydrophobicityontheconformationalchangesofadsorbedfibrinogen.JournalofColloidandInterfaceScience,1991,144(1):271~28130,,31BonfiedTL,ColtonEandAndersonJM.JBiomedMaterRes,1989,23:53532SangenO,AikawaK,NakanoHetal.InteractionofTis-sueCellswithPolymerSurfacesI.HokolouHimeJiKoguoDaigaku,1984,37(A):2733KaelbleDH,MoacaninJ.Asurfaceenergyanalysisof2003682..88(68)bioadhesion,Polymer,1977,18:47534BauschmidtP,SchaldachM.Theelectrochemicalaspectsofthethrombogenicityofamaterial,J.Biomeg.1997,1:26135BauschmidtP,SchaldachM.Alloplasticmaterialsforheartvalveprosthesis,Med.&Biol,Eng.&Cmput,1980,18:49636ToshioHata,/Yasuakikitazakia