晚期糖基化终末产物AGE与衰老

2010985CHINESEJOURNALOFGERIATRICDENTISTRYSEPTEMBER2010VOL.8NO．5。。(advancedglycosylationendproducts,AGEs)、。AGEs[2]。AGEs[3]AGEs。AGEs、。1.AGEs、AGEsAGEs[4]。SchiffAmadori、、、AGEs[56]。AGEs(1)Amadori。(2)AmadoriAmadori—3-(3-DG)AGEs。(3)AmadoriAGEs。、、。、AGEs。AGEs(CML)、(Pentosidine)、3-、(Imidazolone)、(Hy-droimidazolone)、(Pyrraline)、、、、、(Crossline)。AGEs、、、、、、AGEs[78]。,、、、、、、、,AGEs。,(),、AGEs(AGEs)*【】(advancedglycosylationendproducts,AGEs)。AGEs。AGEs[1]。AGEsAGEs、、。[]R781.6[]A[]1672-2973(2010)05-0314-04*“973”2007CB-507405100853100853··314··CHINESEJOURNALOFGERIATRICDENTISTRYSEPTEMBER2010VOL．8NO．52010985[9]。AGEs[10]。2.AGEsAGEs、、AGEs。AGEs[11]RAGEsAGEs,I(IL-I)、I、(TNF-a)、(PDGF)、-NF-kB。、。RAGEI、-48、80K-H、galectin-3。RAGENeeper1992RAGE。AGEs、/1(amphoterin/highmobilitygroupbox1,HMGB1)、S100/(calgranulin)、β(amyloid-βprotein,Aβ)4。、、、、、、。3.AGEs3.1AGEs[12]、。CMLAGEs[13]Sell。:AGEs,。／:、、、、、。,,,,。、、、、、。AGEs,。Monnier[14],,AGEs,。、[15]、。、[16]AGEs30。AGEsAGEs。RAGE[17]、、、AGEs,AGEs,AGEs、、()、、、。3.2。AGEsAGEsAGEs、、、。NO315··2010985CHINESEJOURNALOFGERIATRICDENTISTRYSEPTEMBER2010VOL.8NO．5。Vlassara[8]、AGEs。AGEs[18]。AGEsNF-kB,KajiAGEs,,AGEs,。[19]AGEs。3.3AGEs[19]。、。AGEs。AGEsAGEsAGEs、L-1α、L-6、TNF-α,[20]。3.4AGEsβ－AGEs、。。AβRAGEAβ、。10％[20]。、。4.AGEsAGEs。AGEs、。[1]VlassaraH.Recentprogressinadvancedglycationendprod-uctsanddiabeticcomplications.Diabetes,1997,46(Suppl2):s19-25[2],.[J].200218(3)246-249[3],.[J]..2008,29(1):12-15.[4]CeramiC,FoundsH,NichollL,etal.Tobaccosmokeisasourceoftoxicreactiveglycationproducts[J].ProcNatlAcadSciUSA,1997;94:13915-13920[5]HamelinM,Borot-LaloiC,FriguetB,etal.IncreasedlevelofglycoxidationproductN(epsilon)-(carboxymethyl)lysineinratserumandurineproteinswithageing:linkwithglycoxidativedamageaccumulationinkidney[J].ArchBiochemBiophys,2003,411(2)215-222[6]PeppaM,UribarriJ,VlassaraH.Theroleofadvancedglyco-sylationendproductsinthedevelomentofatherosclerosis[J].CurrDiabRep,20044:31-36[7]VerbekeP,ClarkBFC,RattanSIS.Modulatingcellularaginginvitro:Hormeticeffectsofrepeatedmildheatstressonproteinoxi-dationandglycation[J].ExperimentalGerontology,2000,35:787-794[8]MakitaZ,BucalaR,RayfieldEJ,etal.Diabetic-uremicserumadvancedglycosylationendproductsarechemicallyreactiveandresistanttodialysistherapy[J].Lancet,1994,343:1519-1522[9]RamasamyR,VannucciSJ,YanSSD,etal.AdvancedglycationendproductsandRAGE:acommonthreadinaging,diabetesneurodegenerationandinflame-mation[J].Glycobiology,2005,15(7):16-18[10]RojasA,CavedaL,RomayC,etal.Effectofadvanced316··CHINESEJOURNALOFGERIATRICDENTISTRYSEPTEMBER2010VOL．8NO．52010985、2(P0.05)。3.。3、[2]。。75%,。、GLUMA、MSCOAT[3]。Nd:YAG、。[4]。。。。。。。。4。。。[1].Logistic[J].20086(2)65-68[2].[M].3.2008144[3].[J].200925(4)486-487[4].[J].200321(5)413-414(2010-06-24)9456281089.49621433266.7glycosy-lationendproductsontheinductionofnitricoxidesynthaseinmu-rinemacrophages[J].BiochemBiophysResCommun,1996,225(2):358-362[11]RainaAK.PerryG,NunomuraA,etal.HistochemicalandIm-munocytochemicalApproachestotheStudyofOxidativeStress[J].ClinChemLabMed,2000,38(2):93-97[12]AmanoS,KajiY,OshikaT,etal.Advancedglycationendproductsinhumanopticnervehead[J].BrJOphthalmol,2001,85(1):52-55[13],,.[J].2002,33(1)65-68[14]MonnierVM,VishwanathV,FrankKE,etal.RelationbetweencomplicationsoftypeIdiabetesmellitusandcollagen-linkedfluo-rescence[J].NEnglJMed,1986,314(7):403-408[15],,.、[J].199830(2)185[16],,.AGEs[J].200626(6):725-726[17],,,.[J].200829(2)125-129[18]Jandeleit-DahmK,CooperME.TheroleofAGEsincardiovasculardisease[J].CurrPharmDes,2008,14:979-986[19],.[J].,2009,31(3):187-190[20]Hein,WeiH,LehmannG,etal.Advancedglycationendproductodificationofoneroteinsandboneremodelling:Hypothesisandreliminaryimmunohistochemicalfindings[J].AnnRheumDis,2006,65:101[21].[J].20031(1)2-4(2010-05-10)(283)317··