您好,欢迎访问三七文档
当前位置:首页 > 商业/管理/HR > 质量控制/管理 > 小檗碱的结构修饰研究进展-崔秋兵
*6111372009-04-092007BAI40B052007BAI40B031974-。Tel02881309735E-mailc2q00b5@yahoo.com.cn*Tel13730605702。9DNA、RNA。。R284.1B1001-1528201004-0642-04berberine、、。、、、1-4。。。1。118、9、12、139。1.188-Wistar5。1.299、。96。9-30mg/kg·d95%。9Zhang79-2G9G。。29-pang89-DNA。、、。Long9、93。DNA。32。9-104RGc-myc。9-16-。24620104324ChineseTraditionalPatentMedicineApril2010Vol.32No.439-、49-9DNA、RNA。1.31313-11。13-12、、HSV1、HSV2。Mar-co1313-GDNA。G。KiDukPark1413-5。13-4-MIC=1~81g/mL。513-1.49、10151~3HSP27。KinukoIwasa168、128813-128--12--、、、。3、8、9、1281~20123、91~2017。Wistar。2、3、8、9、10、1381~10132、3、9、101~518。、、、。1.519、、4~18。、、、、、、。20。28、13。2.168、21STZ、。61322、、。9、1214。8、132、3、9、10、、23。34620104324ChineseTraditionalPatentMedicineApril2010Vol.32No.4、。。2.214N-247。7N-9252699-。2711、12、、、1~42、3、9、101~4、、。D1、D2L-SPDD1D2。KinukoIwasa2813-23-。EstelaR29。。38。309。8。31-34。。91.J.200786167-186.2.J.200226276-80.3.J.200722873-75.4.J.2008438773-787.5.8-、CN1974569AP.2007-6-6.6FumitakaShimada.DerivativesofberberineCompilerUS3884911P.1975-5-20.7ZhangWan-JinOuTian-MiaoLuYu-Jingetal.9-SubstitutedberberinederivativesasG-quadruplexstabilizingligandsintelo-mericDNAJ.BioorgMedChem2007155493-5501.8PangJi-YanQinYongChenWen-Huaetal.SynthesisandDNA-bindinganitiesofmonomodifiedberberinesJ.BioorgMedChem2005135835-5840.9LongYu-HuaBaiLi-PingQinYongetal.Spacerlengthandattachingposition-dependentbindingofsynthesizedprotoberberinedimerstodouble-strandedDNAJ.BioorgMedChem2006144670-4676.10MaYanOuTian-MiaoHouJin-Qiangetal.9-N-SubstitutedberberinederivativesStabilizationofG-quadruplexDNAanddown-regulationofoncogenec-mycJ.BioorgMedChem2008167582-7591.11.13-CN1629160AP.2005-6-22.12.13-13-CN1923202AP.2007-3-7.13FranceschinMRossettiLD’AmbrosioAetal.NaturalandsyntheticG-quadruplexinteractiveberberinederivativesJ.BioorgMedChemLetter2006161707-1711.14ParkKDLeeJHKimSHetal.Synthesisof13-substitu-tedbenzylberberineandberberrubinederivativesasantifungalagentsJ.BioorgMedChemLett2006163913-3916.15Kureha.ChemicalindustryCo.Ltd.Tokyo103JP.Berberinederivatesforhsp27productionEuropeanPatentApplicationEP0813872A1P.1997-6-18.44620104324ChineseTraditionalPatentMedicineApril2010Vol.32No.416IwasaKLeeDUKangSIetal.Antimicrobialactivityof8-alkyl-and8-phenyl-substitutedberberinesandtheir12-bromode-rivativesJ.NatProd19986191150-1153.17.、CN101104618AP.2008-1-16.18KimJH.Pharmaceuticallyavailableprotoberberinesaltsderiva-tivesandprotoberberinesaltederivativesandprotoberberinderiv-ativesandsaltsthereofCompilerUS008356P.1999-12-28.19.CN101113149AP.2008-1-30.20.、CN1990487AP.2007-7-4.21.CN1872852AP.2006-12-6.22.1313a-WorldPatentsWO2008/040192P.2008-4-10.23.1313a-CN101153039AP.2008-4-2.24.J.19966413-18.25.J.20033417-12.26.J.2004355393-396.27.、CN1900075AP.2007-1-24.28IwasalKKamigauchilMUekMetal.Antibacterialactivityandstructure-activityrelationshipsofberberineanalogsJ.EurJMedChem199631469-478.29EstelaR.CorrecheSebastianAetal.Antioxidantandcytotox-icactivitiesofcanadineBiologicaleectsandstructuralaspectsJ.BioorgMedChem2008163641-3651.30OndaM.Utilizationofprotopineandrelatedalkaloids.VI.TransformationofBerberineto10β-methylhexahydrobenzoC.Phenanthridinederivativechemical&pharmaceuticalbulletin1973211333-1337.31.J.2007233201-20432.2J.20071710559-562.33.HepG2mRNAJ.20072391145-1147.34.J.2007385725-728.5300032009-09-121974-、。Tel07715802167E-mailfhycsp@tom.com、、、、、、、、、。R969.1B1001-1528201004-0645-04chlorogenicacidcaf-feicacidquinicacid。、1。“”。。12、3、45、6。24h。-5。2~3kg300g。54620104324ChineseTraditionalPatentMedicineApril2010Vol.32No.4
本文标题:小檗碱的结构修饰研究进展-崔秋兵
链接地址:https://www.777doc.com/doc-5748042 .html