炎症动物模型探要-杨巧芳

第26卷第3期2008年3月CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEVo.l26No.3Mar.2008杨巧芳,孟庆刚(,100029):阐述了各种炎症动物模型的制作方法及机理,根据发病原因主要分为非特异性炎症反应模型感染性炎症模型和变态反应性炎症模型非特异性炎症反应模型模拟炎症不同病理时期造成毛细血管通透性模型耳肿胀或足肿胀模型以及肉芽肿模型;变态反应性模型主要包括大鼠佐剂性关节炎模型接触性皮炎模型及气囊滑膜炎模型总结认为对于不同的药理实验选择更适合的炎症模型是实验成功的前提和保障:炎症;动物模型:R-33:A:1673-7717(2008)03-0516-02DiscusstheAnmialModelaboutInflammationYANGQiao-fang,MENGQing-gang(BeijingUniversityofChineseMedicine,Beijing100029,China)Abstrac:tWeintroducevariousmethodsandmechanismofanimalmodelsaboutinflammationincludingnon-speci-ficityinflammationmode,linfectiveinflammationmodelandabnormalreactiveinflammationmodelaccordingtocauseofdisease.WesimulatesdifferentpathologyperiodintheNon-specificityinflammationmodelincludingcapillarypermea-bilitymode,lswellingofear,forcedfootmodelandgranulomamode.lTheabnormalreactiveinflammationmodelincludesadjuvant-inducedarthritis,contactdermatitisandaerostatsynovitismode.lAllinal,lweconsideritapremiseonac-complishingtheexperimentforustoselectmoresuitablemodelindifferentmedicineexperiments.Keywords:inflammation;animalmodel:2007-09-14:(30672642);(2004B4SF121,2005E11SF215);(2001DEA20010):(1975-),,,,,::(1964-),,,,Emai:[e-mail],,,,,,,,();;,13,;;,1.1毛细血管通透性增高模型,,,,,,,,,,,,1.2小鼠耳肿胀模型,,,,,,,,[1],,H1,1.3足跖肿胀模型,,,516DOI10.13193/j.archtcm.2008.03.69.yangqf.083第26卷第3期2008年3月CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEVo.l26No.3Mar.2008,70%~100%,6~8h,,,5,,,,,;,A,A,5-HT;[2]1.4肉芽肿模型,,,,,,,[3]1.5去肾上腺大鼠模型[4],,,,,2,,,,,,33.1佐剂性关节炎1954stoerk,,,,RA,,,,T,,T,,,,,[5]3.2PC致小鼠接触性皮炎模型2,4,6-(PC),,,PC,,,PC[3]3.3气囊滑膜炎模型,,/0,,,,,[6]4,,,,(1),;,,,(2),5-HT,,Pichat[7],,H1(3),/0,,(4),,,,,(5),,,,,,,,,,[1],,,.[J].,2006,22(5):377.[2]GadoK,GiglerG.Zymosaninflammation:anewmethodsuit-ableforevaluatingnewanti-inflammatorydrugs[J].AgentsActions,1991,32(1/2):119.[3].[M].2.:,2006:273,316.[4],,,.[J].,2005,25(3):301-303.[5],,.[J].,2004,16(2):1-3.[6],,,.[J].,2006,6(3):182-184.[7]PichatP,AngelI,ArbillaS.Anti-inflammatorypropertiesofmizolastineafteroraladministrationonarachidonicacid-in-ducedcutaneousreactionintherat[J].Arzneimittelforschung,1998,48:173-178.517