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FOODANDFERMENTATIONINDUSTRIES1822013Vol.39No.8Total308112140071624007151、、。、、、。。2013－03－192013－07－13phloridzinphlorizin1-2-beta-D--46--3-4--C21H24O10436.411。1835。。、、、2－4。。1、。Gosch15AMalonyl-CoAp-Ap-cou-maroyl-CoA。p-ANADPH4-A4-hydroxydihydrocin-namoyl-CoAA4-A。、。Dare6enoylreductase-likeENRL-3ENRL-5。。、、、、1。、、7－10。。、、。。1995Jham11。、。。12。28－9。。、、、、HPCPCHSCCC13－15。16D－10195.6%17ADS-780%99.8%。14HPCPC98.1%。2013398308183Xü18HSCCC98.2%。HPCPC、、、19。。。HPCPC、HSCCC。33.1。。1。20。Ascencio-Cabral213.0mg/L。。Petkovsek22。3.2。、、。23。SGLTsGLUTs2。324、、。Zhao252。“”、26－27。sglt1cyp2b10ephx1glut228。29－30。。3.3。31SODCAT。VasanthaRupasinghe32VE。33。3.4、。34CCL4。Chang35MAPKNF-kB。36。37。hCNTS38。、、4。4。39。、、、。4.1。、40。FOODANDFERMENTATIONINDUSTRIES1842013Vol.39No.8Total308genistein41。2。42。。4.2。Saku-ma2743γ-Na+SGLT1。4.3。。。44。cAMP45。5。。12、3。2。、。1GoschCHalbwirthHStichK.PhloridzinbiosynthesisdistributionandphysiologicalrelevanceinplantsJ．Phytochemistry2010718/9838－843.2.J．20073112192－195.3.J．20093019279－282.4EhrenkranzJRLLewisNGRonaldKCetal.PhlorizinareviewJ．Diabetes/metabolismresearchandreviews200521131－38.5GoschCHalbwirthHKuhnJetal.BiosynthesisofphloridzininappleMalusdomesticaBorkh.J．PlantScience20091762223－231.6DareAPTomesSCooneyJMetal.TheroleofenoylreductasegenesinphloridzinbiosynthesisinappleJ．PlantPhysiologyandBiochemistry2013http//dx.doi.org/10.1016/j.plaphy.2013.02.017.7.J．2011139332－334.8.J．20113200215.9.、J．201125123－28.10.RP-HPLCJ．2010305900－902.11JhamG.High-performanceliquidchromatographicquan-titationofphloridzininappleseedleafandcallusJ．JournalofChromatographyA19967192444－449.12.J．20025229－235.13.J．200826413－16.14.HPCPCJ．2010274645－649.15KammererJBoschetJKammererDRetal.Enrich-mentandfractionationofmajorappleflavonoidsphenolicacidsanddihydrochalconesusinganionexchangeresinsFOODANDFERMENTATIONINDUSTRIES1862013Vol.39No.8Total308rivingfromappleJ．InnovativeFoodScience＆Emer-gingTechnologies200783443－450.43IkumiYKidaTSakumaSetal.Polymer－phloridzinconjugatesasananti-diabeticdrugthatInhibitsglucoseabsorptionthroughtheNa+glucosecotransporterSGLT1inthesmallintestineJ．JournalofCon-trolledRelease2008125142－49.44.J．201036263.45JungELeeJHuhSetal.Phloridzin-inducedmelano-genesisismediatedbythecAMPsignalingpathwayJ．FoodandChemicalToxicology200947102436－2440.CurrentresearchstatusonphloridzinTANSi1ZHOUZhi-qin121CollegeofHorticultureandLandscapeArchitectureSouthwestUniversityChongqing400716China2KeyLaboratoryofHorticultureScienceforSouthernMountainousRegionsMinistryofEducationChongqing400715ChinaABSTRACTPhloridzinisakindofdihydrochalconemainlyfoundintheplantsofthegenusMalusMill.Thecur-rentliteraturesuggeststhatPhloridzinhasawidevarietyofbiologicalactivitiesincludinganti-hypoglycemiceffectanti-oxidationandanti-cancer.Inthispaperthecurrentresearchstatuswasreviewed.Thesynthesisandgrowthdis-tributionanalyticaltechniquesbiologicalactivityaswellasutilizationofphloridzininfoodandmedicineweresum-marized.Finallythefutureresearchdirectionsforphloridzinwereproposedtoprovidenewinformationforfurtherex-ploitationandutilizationinChina.Keywordsphloridzinsynthesisanddistributionanalysisanddetectionbiologicalactivityutilization2013398308185J．LWT-FoodScienceandTechnology20114441079－1087.16.D-101J．2010357217－221.17.J．2007232213－217.18XüKLüHQüBetal.High-speedcounter-currentchromatographypreparativeseparationandpurificationofphloretinfromappletreebarkJ．SeparationandPurifi-cationTechnology2010723406－409.19.J．200422111176－1181.20.J．2007403492－498.21Ascencio-CabralAGutiérrez-PulidoHRodríguez-GarayBetal.PlantregenerationofCaricapapayaL.throughsomaticembryogenesisinresponsetolightqualitygellingagentandphloridzinJ．ScientiaHorticulturae20081182155－160.22MikulicPMSlatnarAStamparFetal.Phenoliccom-poundsinappleleavesafterinfectionwithapplescabJ．BiologiaPlantarum2011554725－730.23.J．200097442－448.24.J．20062712714－717.25ZhaoHYakarSGavrilovaOetal.Phloridzinim-proveshyperglycemiabutnothepaticinsulinresistanceinatransgenicmousemodeloftype2diabetesJ．Diabe-tes200453112901－2909.26KoboriMMasumotoSAkimotoYetal.Phloridzinre-ducesbloodglucoselevelsandaltershepaticgeneexpres-sioninnormalBALB/cmiceJ．FoodandChemicalToxicology20125072547－2553.27NajafianMJahromiMZNowroznejhadMJetal.Phlo-ridzinreducesbloodglucoselevelsandimproveslipidsmetabolisminstreptozotocin-induceddiabeticratsJ．MolecularBiologyReports20123955299－5306.28SakumaSSagawaTMasaokaYetal.Stabilizationofenzyme-susceptibleglucosidebondsofphloridzinthroughconjugationwithpolyγ-glutamicacidJ．JournalofControlledRelease20091332125－131.29.SGLT2J．2010416453－456.30.2J．2010305321－323.31.J．2012374195－198.32VasanthaRHPYasminA.Inhibitionofoxidationofa-queousemulsionsofomega-3fattyacidsandfishoilbyphloretinandphloridzinJ．Molecules2010151251－257.33XiangLSunKLuJetal.Anti-agingeffectsofphlo-ridzinanapplepolyphenolonyeastviatheSODandSir2genesJ．BioscienceBiotechnologyandBio-chemistry2011755854－858.34.CCl4J．201026547－50.35ChangWTHuangWCLiouCJ.Evaluationofthean-ti-inflammatoryeffectsofphloretinandphlorizininlipopo-lysaccharide-stimulatedmousemacrophagesJ．FoodChemistry20121