银杏叶提取物的研究进展

11112*1.4101282.410128：介绍了银杏叶提取物的活性成分及其含量、保健功能的研究进展，并对银杏叶提取物在食品、药品等领域的综合利用进行了阐述，并对研究与应用前景提出了展望，以便为银杏叶提取物开发应用提供参考。银杏叶提取物；活性成分；保健功能GinkgoBilobaLeafExtractResearchProgressXUFang1LIJie1MAOYu1XUXiao-juan1HEJian-hua2*1.FoodScienceandTechnologyCollegeHunanAgriculturalUniversityChangsha410128HunanChina2.AnimalScienceandTechnologyCollegeHunanAgriculturalUniversityChangsha410128HunanChinaAbstractThispaperreviewedtheadvancedinformationintheactiveingredientsofleafextractofGinkgobilobaanditspharmacologicalfunction.ComprehensiveUtilizationofGinkgobilobaleafextractinfood，medicineandotherfieldswereanalyzedindetail.KeywordsGinkgobilobaextractactiveingredientpharmacologicaleffects2011DFA30490-21989—。*。FoodResearchAndDevelopment201383416DOI10.3969/j.issn.1005-6521.2013.16.035GinkgoBilobaLinn、、、、“”[1]。、、、、[2]。《》《》、、、。1966WillarnarSchwabeExtractofGinkgobilobaEGb761。、、、、。、。1ExtractofGinkgobiloba[3]。SchwabeEGb76124%6%0.0005%7.0%13.0%2.0%20%4.0%5.0%3.0%3.0%。200[4]。、。1.1。5.9%[5]403264[6]。isorhamnetin、kaempferolquercein33124、。、、、[7]。、、。1.20.1%～0.6%。GinkgolideHilobalide。、A、B、C、J、M5。1.3、、l7。HPLC92.26mg/g846.9%[8]。、。4-ALGBP-A-BLGBP-B2。VE、VB6、VC、PP4.09、2.90、81.47、9.43、1.69mg/g[8]。25、、、。4.448、24.48、539.3、6844μg/g[9]。1.4、、。。、。—1.90%。334-。334-P。22.12.1.1。Nemcsik[10]2B。[11]。Mozet[12]。2.1.2、[13]EGbNOS、NO、。EGb[14]。28dTCTG。0.5、1.0、3.0g/kg2TC12.7%27.9%12.1%TG25.6%24.8%20.7%。《》[15]。2.1.3plateletactivingfactorPAF、。PAF、PAFPAF[16]PAF。2.22.2.1。、[17-19]。CD4、、徐芳，等：银杏叶提取物的研究进展125。[20-21]。2.2.2EGB761、、。EGb[22]。、EGB761EGB761。、。EGB761BastianettoStephane[23]NOC。2.3、EGbO2-、·OH、NO、。GBBBGA。、、、。DPPHEGb[24]EGb。2.4[25]。EGB。CCl4EGBCCl4。ALTAST54%65%EGB[26]。EGB[27]。2.5。、、[28]。。。EGB761[29]。3、、。50。3.1。、、。、。。3.280GBEGBE。GBE、。、、、、。、。3.3。GBE、、、。GBE、。[30]。徐芳，等：银杏叶提取物的研究进展1264。。。、。。。[1].[M]．:,1988:2[2],．[M]．:,1993:6-14[3],,.[J].,2011,42(7):545-546[4],,,.[J].,2011(7):3-4[5],,.[J].,2005(4):42-47[6],,.[J].,2009,202(1):14-15[7],,．[J].,2001,7(5):46-47[8],,,.[J].,2001,26(4):335-336[9],,．[J]．,2006,9(11):1009-1010[10]NemcsikJ,KordasK,EgresitesJ．SynergisticInteractionofEndoge－nousPlatelet-activatingFactorandVasopressininGeneratingAnginainRats[J].EurJPhannacol,2004,498(1/3):195[11],,,．[J]．,2007,19(3):293-301[12]MozetC,MartinR,WeltK,etal.CardioprotectiveElectofEGb761onMyocardialUltrastruetureofYoungandoldRatHeartandAn-tiox－idantSta-TusDuringAcuteHypoxla[J].AgingClinExpRes,2009,21(1):14-21[13],,,．Egb761[J].,2007,16(3):153-155[14]．[J]．,2008,36(3):149-150[15],,,．[J]．,2000,7(2):135-136[16]ChenP,OzcanM,HarnlyJ.Chromatographicfingerprintanaly-sisforevaluationofGinkgobilobaproducts[J].AnalBioanalChem,2007,389(1):251-261[17]ZhangXY,ZhouDF,CaoLY,etal．TheeffectsofGinkgobilobaex－tractaddedtohaloperidolonperipheralTcellsubsetsindrug-freeschizophrenia:adouble-blind,placebo-controlledtrial[J].Psye－hophar-maeology,2006,188(1):12-17[18]AhmetM,RKemalK,VatanT,etal．Effectsofmexiletine,Ginkgobilobaextract(EGb761),andtheircombinationonexperiment-talheadinjury[J]．NeurosurgRev,2003,26(4):288-291[19]AhlemeyerB,KrieglsteinJ.NeuroprotectiveeffectsofGinkgobilobaextract[J]．CellMolLifeSci,2003,60(9):1779-1792[20]KennedyDO,ScholeyAB,WesnesKA.Thedose-dependentcogni－tiveefectsofacuteadministrationofGinkgobilobatohealthyyoungvolunteers[J]．Psychopharmacology,2000,151(4):416-423[21]WesenesKA,WardT,Mcgintya,eta1．Thememoryenhance-ingef－fectsofaGinkgobiloba/Panaxginsengcombinationinhealthymid－dle-agedvolunteers[J].Psychopharmaeology,2000,152(4):353-361[22],,,.[J].,2007:43-44[23]DasA,SHnkerG,NathC,etal．Acomparativestudyinrodentsofstandardizedextractsofbacopamonnieraandginkgobilobaanti－cholinesteraseandcognitiveenchancingactivities[J]．PharmacologyBiolchemistryandBehavior,2002,73(4):893-900[24]ChenX,chenWZ.RecentphremacologicalprogressofGinkgobilbaextractforcardiovascularandneuronaldisease[J].ChinJIntegtradWestMed,1996(2):300[25],,,.[J]．,2011,31(6):76-78[26]Chavez-MoralesRM,Jaramillo-JuarezF,PosadasdelRioFA,etal．ProtectiveeffectofGinkgobilobaextractonliverdamagebyasingledoseofCCl(4)inmalerats[J]．HumExpToxicol,2011,30(3):209-216[27]YiSY,NanKJ,ChenSJ,etal．EffectofextractofGinkgobi-Iobaondoxorubicin-associatedcardiotoxicityinpatientswithbreastcancer[J]．ZhongguoZhongXiYiJieHeZaZhi,2008,28(1):68-70[28],,．[J]．,2001,8(5):54-56[29]ThiagarajanG,ChsndaniS,RaoSH,etal.Molecularandcelluaras－sessmentofginkgobilobaextractasapossibleophthalmicdrug[J].ExperimentalEyeResearch,2002,75(4):421-430[30],,.[J].,2011,21(4):14-152012-11-25徐芳，等：银杏叶提取物的研究进展127