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DNA31,2221,­(1230026)(2230026),.,DNA,.DNA,,,DNAasatemplateindirectingtheself2assemblyofnanoparticlesZHUChun2Ling1,2LIUYun2Ping2HUANGWen2Hao2CHENZu2Yao1,­(1ChemistryDepartment,UniversityofScienceandTechnologyofChina,Hefei230026,China)(2DepartmentofPrecisionMachineryandInstrument,UniversityofScienceandTechnologyofChina,Hefei230026,China)AbstractWereviewrecentachievementsintheassemblyandcontrolofnanoparticleswithDNAasatem2plate,includingtypicalpatternsoftheself2assemblednanostructuresandcustomdesignednanoelectronicde2vices.Inaddition,newideasanddirectionsforfutureresearchonbiomolecule2mediatedassemblyofactivede2vicesandbiomolecule2baseddevicesarepresented.KeywordsDNAtemplate,self2assembly,nanostructure,nanoelectronicdevices3(:50003008)2002-11-29,2003-02-17­.E2mail:[e-mail]1,DNA[1].,DNA.,,.,DNA,,,,.,,,DNA,.,,DNA,DNADNA,DNA[2].,51532(2003)8,,.,.DNA,.,DNA,DNA.2DNADNA,Coffer[3].DNACd2+,DNA,Cd2+DNA,DNA,H2S.1CdS,1.2m,DNA1.17m.,CdSDNA,,DNA,.DNA,.,.BraunDNA,,100nm,12m[4].DNA,,,[5].Pd,PtAu[6].,2nmAu55(PPH3)12Cl6Lambda-DNA,,1CdSAu55(PPH3)12Cl6Au,Au,Au,[7].DNA,.,,.MirkinDNA[8],.13nm,,,.,,.DNA,DNA,.,,.TEM(2),DNA,DNA,./,DNA/,DNATm,,DNA,,,,.615DNA/.2DNA3DNA,DNA.,,.,.,DNA,.3.1DNA.,Braun[4]100nm,.Schmid[7]SiO2Au55(PPH3)12Cl6.--0.5+0.5V,.SastryRitcherDNAAuPd,[9].RitcherPd,3.3Pd,Pd,.,RaRb,RRaRb/(Ra-Rb).,,.100,,DNA50nm.,Pd/DNA,.3.2DNA,Mirkin[10],.4,DNA,,71532(2003)8,.,.1015g.4,DNA,,DNA,[11].,,.,,DNA.,DNA[12],5.DNAAu,DNA,,.DNA,.3.3,DNA,DNA[13],/,,DNA.,6,SHDNA,5DNA.,,.,DNA,,DNATm,,,.,.,,,DNA,.6DNA4,.DNA,.,DNA,,,,,,815,,,,DNA[14].DNADNA.DNA,DNA.,[15],,,,[16].,.,.[1]MirkinCA.MRSBulletin,2000,25:43;MirkinCA,Inorg.Chem.,2000,39:2258[2]SeemanNC.J.Biomol.Struct.Dyns.,1990,8:573[3]BighamSR,CofferJL.ColloidsSurfacesA,1995,95:211[4]BraunEY,SivanU.Nature,1998,391:775[5]WirtzD.Phys.Rev.Lett.,1995,75:492[6]RitcherJ,SeidelR,KirschRetal.Adv.Mater.,2000,12:507;RitcherJ,MertigM,PompeW.Appl.Phys.Lett.,1996,69:3851;KumarA,PattarkineM,GaneshKNetal.Adv.Mater.,2001,13:341[7]SchmidG,LiuYP.Nanolett.,2001,1:405[8]MirkinCA,LetsingerRL,StorhoffJJ.Nature,1996,382:607;MucicRC,StorhoffJJ,MirkinCAetal.J.Am.Chem.Soc.,1998,120:12674;StorhoffJJ,LazaoridesAA,MucicRCetal.J.Am.Chem.Soc.,2000,122:4640[9]RitcherJ,MertigM,PompeW.Appl.Phys.Lett.,2001,78:536;SastryM,KumarA.Appl.Phys.Lett.,2001,78:2943[10]EllghnianR,StorhoffJJ,MucicRCetal.Science,1997,277:1078;TatonTA,MucicRC,MirkinCAetal.J.Am.Chem.Soc.,2000,122:6305[11]StroffRM,HopkinsD,HaeberliABetal.J.Clin.Chem.,1999,45:1659[12]ParkSJ,TantonTA,MirkinCA.Science,2002,295:1503[13]FinkHW,SchonenbergerC.Nature,1999,398:407;PorathD,BezryadinA,VriesSDetal.Nature,2000,403:635[14],.,1998,14:205SunXG,BaiCLetal.ActaBiophysicaSinica,1998,14:205(inChi2nese)[15]SamuelIS,PaulVB.Science,1997,277:1242[16]NiemeyerCM,SanoT,SmithCIetal.NuceleicAcidesRev.,1994,22:5530;TrevorD,MarkY.Nature,1998,393:152(ThepuzzleofCoronastemperatures),6000K,,,,.,1000.1990,(SOHO),,.,..,,.,1000.LivermoreLock2heedMartinRyutovaTarbell.2.2,.,5300,000K.,,,,M.M,.,.,.,,,.,,,,,.(PhysicalReviewLetters,16May2003)91532(2003)8